MOCKSVILLE, N.C., April  23, 2026  (GLOBE NEWSWIRE) -- 22nd Century Group, Inc. (NASDAQ:XXII), a tobacco products company focused on nicotine reduction and plant biotechnology, today announced corporate updates regarding

XXII

22nd Century Group Expands Reduced Nicotine Platform Through New Testing Services Agreement with North Carolina State University

22nd Century Strikes Agreement to Enhance Low-Nicotine Tobacco Yields

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 <h3>Information</h3>
 MOCKSVILLE, N.C., April 23, 2026 (GLOBE NEWSWIRE) -- 22nd Century Group, Inc. (NASDAQ:XXII), a tobacco products company focused on nicotine reduction and plant biotechnology, today announced corporate updates regarding
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 <h3>AI Summary</h3>
 22nd Century Group has announced a new testing services agreement with North Carolina State University to validate and enhance the commercial viability of its low-nicotine tobacco products. This initiative aims to improve crop yields and quality, positioning XXII favorably in the evolving regulatory landscape aiming to reduce nicotine addiction.
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 <h3>Key Points</h3>
 <ul><li>22nd Century enters testing agreement with North Carolina State University.</li><li>Focus on improving low-nicotine tobacco crop yields and quality.</li><li>Collaboration aims to enhance the commercial viability of VLN products.</li><li>Company aligns with FDA&#039;s proposed nicotine standards for public health.</li><li>CEO emphasizes innovations in plant science for sustainable tobacco production.</li></ul>
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 <h3>Companies Mentioned</h3>
 <ul><li>North Carolina State University (N/A): Collaboration could enhance XXII&#039;s product development and agricultural viability.</li></ul>
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 <h3>Corporate Developments</h3>
 This announcement fits into the &#039;Corporate Developments&#039; category as it demonstrates proactive steps taken by XXII to enhance its product offerings and align with regulatory expectations, which could substantiate its market value.
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 <ul><li>The testing agreement could lead to improved crop yields and product scalability.</li><li>Alignment with regulatory health initiatives may enhance XXII’s market positioning.</li><li>Positive research outcomes could attract more investment and funding.</li><li>Any updates on product commercialization will significantly impact stock price.</li></ul>
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 <h3>Key Facts</h3>
 <ul><li>VLN cigarettes authorized by FDA in December 2021.</li><li>Current testing partnership with North Carolina State University.</li><li>Aim to achieve better quality and higher yields of low-nicotine tobacco.</li><li>VLN products reduce nicotine consumption by 95% compared to traditional cigarettes.</li><li>Research includes field evaluations and nicotine quantification.</li></ul>
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 <h3>Trading Thesis</h3>
 XXII is poised for growth as it strengthens its low-nicotine tobacco offerings; buy with a 6-12 month outlook.
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<link type="text/css" rel="stylesheet" href="https://www.globenewswire.com/styles/gnw_nitf.css"></link>MOCKSVILLE, N.C., April 23, 2026 (GLOBE NEWSWIRE) -- 22nd Century Group, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/XXII">XXII</a>), a tobacco products company focused on nicotine reduction and plant biotechnology, today announced corporate updates regarding a new testing services agreement with North Carolina State University aimed at validating tobacco varieties featuring improved leaf quality and increased crop yields with the same low-nicotine content. The initiative builds upon 22nd Century's proprietary reduced nicotine content technology platform, which utilizes advanced plant breeding and biotechnology to reduce nicotine content in tobacco to minimally addictive levels. The Company's reduced nicotine tobacco is the foundation of its FDA-authorized VLN&#xAE; combustible cigarette products and represents years of scientific development in plant genetics and regulatory science. The newly signed testing services agreement will focus on confirming commercial viability of tobacco varieties incorporating 22nd Century's patented low-nicotine genetics to increase yield, improve leaf quality and consistency, support more efficient, scalable production, ensure long-term sustainability for contracted growers, and preserve the integrity of the Company's reduced-nicotine characteristics. Larry Firestone, Chief Executive Officer of 22nd Century Group, stated "This is about producing robust reduced nicotine tobacco plants from the ground up. As policymakers and regulators around the world continue to focus on health, wellness, and sensible standards that reduce nicotine dependence, we believe our VLN&#xAE; products are in prime position to support that global dialogue. Our products and technology directly align with the U.S. FDA's proposed maximum nicotine standard and broader global public health objectives aimed at lowering addiction levels across the U.S. and around the world. This important research only further strengthens our commitment and consistent track record of demonstrating commercial viability. We believe our reduced nicotine VLN&#xAE; cigarette products are the best alternative to highly addictive standard cigarettes and other nicotine products in the market if the FDA's policies were implemented." "By continuing to partner with North Carolina State University, one of the nation's premier agricultural research institutions, we are investing in next-generation plant science to further strengthen our proprietary tobacco genetics. Improving the yield and quality of low-nicotine tobacco is not just good agronomy, it strengthens American farming, enhances supply chain resilience, and ensures that our reduced nicotine platform can scale reliably and sustainably. We are combining innovation, regulatory alignment, and agricultural excellence to deliver a product designed for the future of nicotine policy and adult consumer choice." Under the terms of the testing services agreement, researchers at North Carolina State University will work alongside 22nd Century's plant science team to evaluate genetic pathways associated with increased harvest volume per acre and an even better-quality leaf for our new lines of reduced nicotine tobacco. The research is expected to include field evaluations, quality assessments, yield calculations, and alkaloid characterization with nicotine quantification. The collaboration with North Carolina State University reflects 22nd Century's continued commitment to science-driven innovation across the entire value chain, from plant genetics to finished product as we advance our mission to reduce the harms associated with smoking and nicotine. The Company will provide updates as research milestones are achieved. FDA Authorization and Scientific Foundation  VLN&#xAE; low nicotine combustible cigarettes were authorized in December 2021, making them the first and still the only combustible cigarettes authorized by the U.S. Food and Drug Administration specifically to help reduce nicotine consumption.  Decades of independent clinical research and peer-reviewed studies—evaluated as part of the FDA's Modified Risk Tobacco Product (MRTP) authorization process—demonstrated that reducing nicotine content can decrease nicotine intake, increase quit attempts, and reduce overall exposure to nicotine.  FDA-authorized VLN&#xAE; claims include:  <ul type="disc"><li style="text-align:justify;">"95% less nicotine" </li><li style="text-align:justify;">"Helps reduce your nicotine consumption" </li><li style="text-align:justify;">"Greatly reduces your nicotine consumption" </li><li style="text-align:justify;">"Helps you smoke less" </li></ul> About 22nd Century Group, Inc.  22nd Century Group is pioneering the Tobacco Harm Reduction Movement by enabling smokers to take control of their nicotine consumption.  Our Technology is Tobacco Our proprietary non-GMO reduced nicotine tobacco plants were developed using our patented technologies that regulate alkaloid biosynthesis activities resulting in a tobacco plant that contains 95% less nicotine than traditional tobacco plants. Our extensive patent portfolio has been developed to ensure that our high-quality tobacco can be grown commercially at scale. We continue to develop our intellectual property to ensure our ongoing leadership in the tobacco harm reduction movement.  Our Products We created our flagship product, the VLN&#xAE; cigarette using our low nicotine tobacco, to give traditional cigarette smokers an authentic and familiar alternative in the form of a combustible cigarette that helps them take control of their nicotine consumption. VLN&#xAE; cigarettes have 95% less nicotine compared to traditional cigarettes and have been proven to allow consumers to greatly reduce their nicotine consumption.  VLN&#xAE; and Helps You Smoke Less&#xAE; are registered trademarks of 22nd Century Limited LLC.  Learn more at <a href="https://www.globenewswire.com/Tracker?data=fLEtVatEcD9X-5IQAGxmN0ASmjbo-FutI4di6h6JtX7IAPB3rJbb2sDK41wXGWExzZA7GmEVrxmISluhaE8TwSAE0ZZPfCT8HyWJCP_D7cc=" rel="nofollow" target="_blank">xxiicentury.com</a>, on <a href="https://www.globenewswire.com/Tracker?data=qGUkpqu-6nC77fBKMYSqK3TwZgEXW6CSUrpxM1O-tujOfjCfsIg-5LASoJeVVmJh3FjyG42e2NdYiY4viYBDvs9IIfnJ3vQIXL25iqQJZXL-5VuONlZxSzSWkM3zzr7F" rel="nofollow" target="_blank">X (formerly Twitter)</a>, on <a href="https://www.globenewswire.com/Tracker?data=vfyNHb4C22NH8OXc81AulUxeMh5oqmnar28n4rq5x-IF2sIMZcnucGuL9rY92GdNvEDorIk5sJbgrgdYARyDRyu4X8r7Osns0eNkdYlbkFUs7cjQjMolRzYvM04gd5VD" rel="nofollow" target="_blank">LinkedIn</a>, and on <a href="https://www.globenewswire.com/Tracker?data=aluy1QxB2IXyYTHwsHjFWJvKEgNdTkq0ZRHJ01BPl3ajU0K2zvIG3J7VXmaTKj2DPfF9mW9ML2wEEVCLu5-iLG0MP45SA53sIcVls_QBsgY=" rel="nofollow" target="_blank">YouTube</a>.  Learn more about VLN&#xAE; at <a href="https://www.globenewswire.com/Tracker?data=gh1y7Zy0c6-ulOHhTwm6jeQAsztz2_Q5ZTvzG79PzCXCOjBe_xnRfN0ZPZOAhfzQUUPgH7-GDZ7e9PguEzWrrw==" rel="nofollow" target="_blank">tryvln.com</a>.  Cautionary Note Regarding Forward-Looking Statements  Except for historical information, all of the statements, expectations, and assumptions contained in this press release are forward-looking statements, including but not limited to our full year business outlook. Forward-looking statements typically contain terms such as "anticipate," "believe," "consider," "continue," "could," "estimate," "expect," "explore," "foresee," "goal," "guidance," "intend," "likely," "may," "plan," "potential," "predict," "preliminary," "probable," "project," "promising," "seek," "should," "will," "would," and similar expressions. Forward-looking statements include, but are not limited to, statements regarding (i) our expectations regarding regulatory enforcement, including our ability to receive authorization or approval for new products, and (ii) our financial and operating performance. Actual results might differ materially from those explicit or implicit in forward-looking statements. Important factors that could cause actual results to differ materially are set forth in "Risk Factors" in the Company's Annual Report on Form 10-K filed on March 26, 2026. All information provided in this release is as of the date hereof, and the Company assumes no obligation to and does not intend to update these forward-looking statements, except as required by law.  Investor Relations &amp; Media Contact Matt Kreps  Investor Relations  22nd Century Group  <a href="https://www.globenewswire.com/Tracker?data=RLBBJNr3nm-wFPu3tMfFey2W6ZgTYgYO9ZVa_q0iQpcrfscikIpMN6xCpbznB0gzem-TBZzO2npQsitnC2_EOpSdDUyIR4jYK_wrvIMmH_A7vmkTHXz48yr_Qh50crAJUb1rl58_PBGJ54i_gf-jrA==" rel="nofollow" target="_blank">investorrelations@xxiicentury.com</a> 214-597-8200 <img alt="" class="__GNW8366DE3E__IMG" src="https://www.globenewswire.com/newsroom/ti?nf=OTY5NTcxMyM3NTUyMTg2IzUwMDEzMTQ4NA=="></img> <img alt="" src="https://ml.globenewswire.com/media/MDBjM2Y0MjktNGM4NS00M2E4LWE2NDUtMzk5OGJjM2EzYTdiLTUwMDEzMTQ4NC0yMDI2LTA0LTIzLWVu/tiny/22nd-Century-Group-Inc-.png" referrerpolicy="no-referrer-when-downgrade"></img><a href="https://www.globenewswire.com/NewsRoom/AttachmentNg/0c134f7d-c166-4b24-874f-262b3515f650"><img src="https://ml.globenewswire.com/media/0c134f7d-c166-4b24-874f-262b3515f650/small/xxii-logo-png.png" border="0" width="150" height="32" alt="Primary Logo"></img></a>

22nd Century Group has announced a new testing services agreement with North Carolina State University to validate and enhance the commercial viability of its low-nicotine tobacco products. This initiative aims to improve crop yields and quality, positioning XXII favorably in the evolving regulatory landscape aiming to reduce nicotine addiction.

22nd Century Group Expands Reduced Nicotine Platform Through New Testing Services Agreement with North Carolina State University

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