License allows the Company to commence large-scale extraction of castanospermine from the seeds of Castanospermum australe Company will meet with FDA on July 1, 2026, to discuss Non-Notified Letter issued by the Agency

SXTP

60 Degrees Pharmaceuticals Signs Exclusive Patent License Agreement with Florida State University for Non-Prescription Use of Australian Chestnut Extract as a Botanical Supplement

60 Degrees Pharma advances castanospermine licensing; FDA NDIN feedback prompts July meeting

<section class="insight" data-version="1">
  <section data-block="information">
    <h3>Information</h3>
    <p>License allows the Company to commence large-scale extraction of castanospermine from the seeds of Castanospermum australe Company will meet with FDA on July 1, 2026, to discuss Non-Notified Letter issued by the Agency</p>
  </section>

  <section data-block="ai-summary-paragraph">
    <h3>AI Summary</h3>
    <p>60 Degrees Pharmaceuticals announced a licensing agreement with Florida State University to scale castanospermine extraction from Castanospermum australe seeds for non-prescription use. The FDA issued a Non-Notification Letter on the NDIN for Australian Chestnut Extract, with a July 1, 2026 meeting to discuss safety information and revised NDIN. The development could affect SXTP&#039;s regulatory risk and potential commercial timeline.</p>
  </section>

  <section data-block="ai-summary-bullets">
    <h3>Key Points</h3>
    <ul><li>60 Degrees Pharma licenses castanospermine extraction tech with Florida State University.</li><li>NDIN for Australian Chestnut Extract receives FDA Non-Notification Letter.</li><li>FDA meeting set for July 1, 2026 to discuss safety data and NDIN.</li><li>Lead product ARAKODA tafenoquine approved for malaria prevention in 2018.</li></ul>
  </section>

  <section data-block="companies-mentioned">
    <h3>Companies Mentioned</h3>
    <ul><li><strong>60 Degrees Pharmaceuticals, Inc. (SXTP)</strong>: Licensing agreement with FSU to scale castanospermine extraction; potential revenue and regulatory impact for SXTP.</li><li><strong>Florida State University (FSU)</strong>: Licensing partner; not public, potential downstream monetization via technology and collaboration.</li></ul>
  </section>

  <section data-block="category">
    <h3>Industry News</h3>
    <p>Industry News: The article highlights a corporate licensing development and regulatory steps affecting a small-cap pharma company, with potential implications for SXTP&#039;s pipeline, cash flow, and timeline to market.</p>
  </section>

  <section data-block="market-moving">
    <h3>Market-Moving</h3>
    <ul><li>FDA Non-Notification Letter adds regulatory risk to near-term SXTP fundamentals.</li><li>July 1, 2026 FDA meeting could clarify NDIN pathway and revisions.</li><li>FSU licensing partner may enable scalable production of castanospermine.</li><li>Potential upside to SXTP if NDIN revisions proceed favorably.</li></ul>
  </section>

  <section data-block="key-facts">
    <h3>Key Facts</h3>
    <ul><li>Date of press release: June 11, 2026.</li><li>NDIN for Australian Chestnut Extract resulted in an FDA Non-Notification Letter.</li><li>FDA meeting scheduled for July 1, 2026 to discuss NDIN safety information.</li><li>License agreement with Florida State University to scale production of castanospermine.</li><li>Lead product ARAKODA tafenoquine approved for malaria prevention in 2018.</li></ul>
  </section>

  <section data-block="trading-thesis">
    <h3>Trading Thesis</h3>
    <p>Neutral-to-bullish near term; NDIN resolution by mid-2026 could unlock upside for SXTP.</p>
  </section>
</section>


<link type="text/css" rel="stylesheet" href="https://www.globenewswire.com/styles/gnw_nitf.css"></link><ul type="disc"><li><strong>License allows the Company to commence large-scale extraction of castanospermine from the seeds of </strong><strong><em>Castanospermum australe</em></strong> </li><li><strong>Company will meet with FDA on July 1, 2026, to discuss Non-Notified Letter issued by the Agency in response to the Company's recent New Dietary Ingredient Notification (NDIN) to market Australian Chestnut Extract in the U.S.<br></br></strong><u><br></br></u></li></ul>  <p>WASHINGTON, June  11, 2026  (GLOBE NEWSWIRE) -- <a href="https://www.globenewswire.com/Tracker?data=7HPu3tzSaKK5hbhXguUDBCuSLxVeSZ2ptMkDkakqd5_JRtOHEzRK9HdWy0W6m9va_VpnQ4DS1CAY7i1ngGyQWcLqWlXc5jovLGOnxGzmmOHhvFOMz6aCT872GBmqTdUaemtg8hyihkx7h9re3g3rug==" rel="nofollow" target="_blank"><u>60 Degrees Pharmaceuticals, Inc.</u></a> (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/SXTP">SXTP</a>, SXTPW)) (the "Company" or "60 Degrees Pharma"), a pharmaceutical company focused on developing new medicines for vector-borne disease, announced that the Company has executed a patent licensing agreement with Florida State University to commence large-scale production techniques to extract and purify castanospermine from the seeds of <em>Castanospermum australe</em> (commonly known as the Australian Chestnut, the Moreton Bay Chestnut, and the Black Bean Tree) for non-prescription uses. Castanospermine is the principal component of Australian Chestnut Extract.</p>  <p>According to recent scientific literature, at low doses, castanospermine modulates carbohydrate metabolism, altering glycogen, glucose levels and other clinical markers. In animal models, high doses have been shown to impact disease outcomes in several therapeutic areas through immunomodulation.</p>  <p>The U.S. Food and Drug Administration (FDA or "the Agency") has issued a Non-Notification Letter to 60 Degrees Pharma providing feedback on the Company's recent filing of a New Dietary Ingredient Notification (NDIN) for Australian Chestnut Extract. 60 Degrees Pharma and the Agency will meet on July 1, 2026, to discuss the feedback, including clarification regarding the minimum required "other safety information" to establish the safety of the proposed use of Australian Chestnut Extract in a dietary supplement. Subsequently, the Company will submit a revised NDIN.</p>  <p><em>Castanospermum australe</em> grows primarily in the Australian states of Queensland and New South Wales, and in Florida, Hawaii, and California. The processed seeds of <em>Castanospermum australe </em>have been a traditional food source in Australia for thousands of years.</p>  <p><strong>About 60 Degrees Pharmaceuticals, Inc.</strong><br></br>60 Degrees Pharmaceuticals, Inc., founded in 2010, specializes in developing and commercializing new medicines for the treatment and prevention of vector-borne disease. The Company achieved U.S. Food and Drug Administration approval of its lead product, ARAKODA&#xAE; (<strong>tafenoquine</strong>), for malaria prevention in 2018. ARAKODA is commercially available in the U.S. and Australia. 60 Degrees Pharmaceuticals, Inc. also collaborates with prominent research and academic organizations in the U.S. and Australia. 60 Degrees Pharmaceuticals, Inc. is headquartered in Washington, D.C., with a subsidiary in Australia. Learn more at <a href="https://www.globenewswire.com/Tracker?data=4UYz-u8rmW_aM_VQZU5Lo8e3V3snnB3MDIhDPkLVtd2D1iOjD-rbrYQinX1_7vQ4iLQ5Wi8SmfIFSw37cQn3OIA9pi2GzsHleNdfv7BQMKReoFmQ6hTny4OrlnglN5GK" rel="nofollow" target="_blank"><u>www.60degreespharma.com</u></a>.</p>  <p>The statements contained herein may include prospects, statements of future expectations and other forward-looking statements that are based on management's current views and assumptions and involve known and unknown risks and uncertainties. Actual results, performance or events may differ materially from those expressed or implied in such forward-looking statements.</p>  <p><strong>Cautionary Note Regarding Forward-Looking Statements</strong><br></br>This press release may contain "forward-looking statements" within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements reflect the current view about future events. When used in this press release, the words "anticipate," "believe," "estimate," "expect," "future," "intend," "plan," or the negative of these terms and similar expressions, as they relate to us or our management, identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy, activities of regulators and future regulations and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following: there is substantial doubt as to our ability to continue on a going-concern basis; we might not be eligible for Australian government research and development tax rebates; if we are not able to successfully develop, obtain FDA approval for, and provide for the commercialization of non-malaria prevention indications for <strong>tafenoquine</strong> (ARAKODA<sup>&#xAE;</sup> or other regimen) or Australian Chestnut Extract in a timely manner, we may not be able to expand our business operations; we may not be able to successfully conduct planned clinical trials or patient recruitment in our trials might be slow or negligible; and we have no manufacturing capacity which puts us at risk of lengthy and costly delays of bringing our products to market. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Company's filings with the Securities and Exchange Commission ("SEC"), including the information contained in our Annual Report on Form 10-K filed with the SEC on March 30, 2026, and our subsequent SEC filings. Investors and security holders are urged to read these documents free of charge on the SEC's website at www.sec.gov. As a result of these matters, changes in facts, assumptions not being realized or other circumstances, the Company's actual results may differ materially from the expected results discussed in the forward-looking statements contained in this press release. Any forward-looking statement made by us in this press release is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.</p>  <p>Media Contact<br></br>Sheila A. Burke<br></br><a href="https://www.globenewswire.com/Tracker?data=vzEzCZd5jxpxCqewpBy3gMBRsmr9JPNhASPLjk0TE0CtWb35_LrcP18BIq_EQTyQs5SmpibJTepzcF9izikekjInTHuvkSbODdhb0knUf_lpRQgWQ6mj7toM_EUuviozY9PbiIbKPOabvdpHvi6orrNCtOaOIMjAFs4V09wz2QoA2nkto9wbEXke8CE6y80N-mIZycqSl74PYVB8OaVYcygiNJvnMK4HOwtpi9c7n6qENRG63FmKTb7bG2Bqde6_GDLVoyXdPxQdg179ydUCAsdcDzyw4bIrVRPIgPhc0gAQMvhO50DI2z_xrJSUoQ2nqdoKTEhNXnz-n5c14Gs7QQnV_42cpF_ra2qLBO23SOtHWcExqjSFsUagcCtl9MRi" rel="nofollow" target="_blank"><u>SheilaBurke-consultant@60degreespharma.com</u></a> <br></br>(484) 667-6330     </p>  <p>Investor Contact<br></br>Patrick Gaynes<br></br><a href="https://www.globenewswire.com/Tracker?data=KBSGxty2G_KygodnH4NvyK2VJX_3W7Hfom58VPr9uhV0fXO-D_gm6YJ8Up9clk05UQV3XhNJ4VR4f_18ZUKfKpKRMvuVD8A-mxbG1S26V2TD-0GHBYB57V-YFZIH6UqYaDJUtEkvNHhIpueR3tCs-A==" rel="nofollow" target="_blank">patrickgaynes@60degreespharma.com</a> </p> <img alt="" class="__GNW8366DE3E__IMG" src="https://www.globenewswire.com/newsroom/ti?nf=OTczNTEzNSM3NjUxMzM5IzIxODIzMzg="></img> <br></br><img alt="" src="https://ml.globenewswire.com/media/YmI4ODEwYjYtNWY1YS00NGY0LTk5MjEtN2RjZWUzZWRkYjE1LTExOTM5MDctMjAyNi0wNi0xMS1lbg==/tiny/Sixty-Degrees-Pharmaceuticals.png" referrerpolicy="no-referrer-when-downgrade"></img><p><a href="https://www.globenewswire.com/NewsRoom/AttachmentNg/c950cab5-27b1-476f-befc-4d92a7389fdd"><img src="https://ml.globenewswire.com/media/c950cab5-27b1-476f-befc-4d92a7389fdd/small/60degrees-logo-rgb-logo-jpg.jpg" border="0" width="150" height="79" alt="Primary Logo"></img></a></p>

60 Degrees Pharmaceuticals announced a licensing agreement with Florida State University to scale castanospermine extraction from Castanospermum australe seeds for non-prescription use. The FDA issued a Non-Notification Letter on the NDIN for Australian Chestnut Extract, with a July 1, 2026 meeting to discuss safety information and revised NDIN. The development could affect SXTP's regulatory risk and potential commercial timeline.

60-degrees-pharmaceuticals-signs-exclusive-patent-license-agreement-with-florida-state-university-for-non-prescription-use-of-australian-chestnut-extract-as-a-botanical-supplement

60 Degrees Pharmaceuticals Signs Exclusive Patent License Agreement with Florida State University for Non-Prescription Use of Australian Chestnut Extract as a Botanical Supplement

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