An ADC with a novel RNA spliceosome modulating payload PH1 paired with a KRAS inhibitor demonstrates synergistic cytotoxic activity against KRAS G12D and G12C- driven pancreatic cancer modelsData supports the broader

AKTX

Akari Therapeutics Reports Breakthrough Preclinical Data Demonstrating Synergistic Activity of AKTX-101 with KRAS Inhibition in KRAS-Mutated Pancreatic Cancer Models

AKTX-101 shows promising synergy in KRAS-driven pancreatic cancer trials

<section class="insight" data-version="1">
  <section data-block="information">
    <h3>Information</h3>
    <p>An ADC with a novel RNA spliceosome modulating payload PH1 paired with a KRAS inhibitor demonstrates synergistic cytotoxic activity against KRAS G12D and G12C- driven pancreatic cancer modelsData supports the broader</p>
  </section>

  <section data-block="ai-summary-paragraph">
    <h3>AI Summary</h3>
    <p>Akari Therapeutics announced positive preclinical findings for AKTX-101 at ASCO 2026, highlighting synergistic activity with KRAS inhibitors in treating difficult pancreatic cancer models. This differentiation from conventional ADCs opens new therapeutic possibilities and extends the application of RNA splicing therapies. Investors should monitor subsequent clinical developments as AKTX-101 progresses towards human trials.</p>
  </section>

  <section data-block="ai-summary-bullets">
    <h3>Key Points</h3>
    <ul><li>AKTX-101 shows synergy with KRAS inhibitors in pancreatic cancer models.</li><li>Positive data presented at ASCO 2026 supports wider RNA splicing therapy.</li><li>AKTX-101 differs from traditional ADCs and does not show antagonism.</li><li>IND-enabling studies for AKTX-101 are ongoing, targeting mid-2027 start.</li><li>Significant differentiation indicated over traditional TROP2-targeting ADCs.</li></ul>
  </section>

  <section data-block="companies-mentioned">
    <h3>Companies Mentioned</h3>
    <ul><li><strong>Akari Therapeutics (AKTX)</strong>: AKTX is advancing its pipeline with promising preclinical data and solid differentiation.</li><li><strong>adagrasib (Unknown)</strong>: This KRAS inhibitor was a key part of synergy studies with AKTX-101.</li></ul>
  </section>

  <section data-block="category">
    <h3>Corporate Developments</h3>
    <p>This falls under Corporate Developments as Akari advances product candidates and clinical strategies significantly, positioning itself uniquely in oncology.</p>
  </section>

  <section data-block="market-moving">
    <h3>Market-Moving</h3>
    <ul><li>Positive ASCO data may boost AKTX&#039;s market perception and stock valuation.</li><li>Clinical trial initiation by mid-2027 could enhance investor interest and stock price.</li><li>Further collaborations or partnerships with oncology firms could drive AKTX shares up.</li><li>New findings may position AKTX-101 as a leader in KRAS-targeting therapies.</li></ul>
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  <section data-block="key-facts">
    <h3>Key Facts</h3>
    <ul><li>AKTX-101 shows synergistic cytotoxic activity with adagrasib in preclinical studies.</li><li>IND-enabling studies for AKTX-101 are ongoing, aiming for mid-2027 trial start.</li><li>Research highlights AKTX-101&#039;s differentiated mechanism against difficult KRAS mutations.</li><li>Results presented at ASCO 2026 further validate AKTX&#039;s approach to RNA splicing.</li></ul>
  </section>

  <section data-block="trading-thesis">
    <h3>Trading Thesis</h3>
    <p>Consider AKTX for speculative investment, potential rise through mid-2027 pending trial results.</p>
  </section>
</section>


<link type="text/css" rel="stylesheet" href="https://www.globenewswire.com/styles/gnw_nitf.css"></link><p align="center"><em>An ADC with a novel RNA spliceosome modulating payload PH1 paired with a KRAS inhibitor demonstrates synergistic cytotoxic activity against KRAS G12D and G12C- driven pancreatic cancer models</em><br></br><br></br><em>Data supports the broader applicability of targeting RNA splicing to attack difficult-to-treat KRAS-driven cancers</em></p>  <p align="center"><em>Findings featured in ASCO 2026 online abstract further differentiate AKTX-101 from TROP2 ADCs utilizing Topoisomerase I inhibitor payloads</em><br></br></p>  <p align="justify">TAMPA, Fla. and LONDON, May  21, 2026  (GLOBE NEWSWIRE) -- Akari Therapeutics, Plc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/AKTX">AKTX</a>), an oncology biotechnology company developing antibody drug conjugates (ADCs) with a novel RNA splicing modulator payload, today announced positive preclinical data featured in an online abstract released in connection with the <a href="https://www.globenewswire.com/Tracker?data=GQYim5hENqMRh_9cFfMCMW_0ne3Ep7XD696ZDxh44bpBOMFSS4Gd--ID1PwRRmTmp_wpcKd1OmCqYs7vTI9-zfWZhNTHj5vVskX6b2vVzmYdVi9eH_c1x2msshO56sku3mC940YtxLCt9e_odkzmTw==" rel="nofollow" target="_blank">American Society of Clinical Oncology (ASCO) Annual Meeting 2026</a> highlighting synergistic cytotoxic activity of AKTX-101 in combination with KRAS inhibition in KRAS-mutated pancreatic cancer models. Access the abstract <a href="https://www.globenewswire.com/Tracker?data=IHxrIM2dO3RycckqyH6YmgYbPf5MehhPdEiDH37ajxUpkIGfBa86KgSyWKYr2KDvqZUq3nubCYmfllzRGtbA0JI_MEcMkmRSLul9aUJQOiY8sN-1dUouciaL4T45KJURy0khhatYXbbtX1kQDcygaPSDw4iICe2djzl3khAdqNGUgZ3WS-KZUF2Wi2VbZfRk6QuL0Pj4XAGl1L3fGm-PmQ==" rel="nofollow" target="_blank">here</a>.</p>  <p align="justify">The data further expands the potential opportunity for Akari's lead TROP2-targeting ADC, AKTX-101, and its proprietary RNA spliceosome-modulating payload beyond the Company's current Phase 1 development plan and supports the broader applicability of targeting RNA splicing as a potential way to treat difficult-to-treat KRAS-driven cancers.</p>  <p align="justify">The ASCO abstract evaluated the activity of AKTX-101 in combination with adagrasib, a KRAS inhibitor, across pancreatic cancer cell lines harboring KRAS G12D and KRAS G12C. In these studies, the combination of AKTX-101 and adagrasib demonstrated synergistic cell killing in KRAS mutant cell lines driven by G12C and G12D. This synergistic inhibition was not observed with the comparator first-in-class topoisomerase I-targeting TROP2 ADCs. Instead, these ADCs exhibited antagonism when paired with adagrasib. These results suggest that AKTX-101 synergy with KRAS inhibitor may be linked to the novel biology of PH1 targeting RNA splicing. The synergy was explained by PH1's unique ability target pre-mRNA transcripts for degradation, including those bearing KRAS mutations driving these cancer models.</p>  <p align="justify">"KRAS has long been considered one of oncology's most important but difficult targets, and while recent KRAS inhibitors have represented meaningful progress, there remains a significant opportunity to further enhance activity and broaden therapeutic impact," said Abizer Gaslightwala, President and Chief Executive Officer of Akari Therapeutics. "These data suggest that our PH1 RNA splicing modulator payload may offer a fundamentally differentiated mechanism capable of enhancing KRAS inhibitor activity in ways not observed with conventional ADC payloads. We believe this represents an exciting opportunity not only for AKTX-101, but potentially for RNA splicing modulation as a new therapeutic strategy across KRAS-driven tumors."</p>  <p align="justify">Dr. Satyajit Mitra, Executive Director and Head of Oncology, stated, "Historically, KRAS mutations have been incredibly difficult to drug, and one may need to approach this problem with drugs of different modalities and mechanisms of action. AKTX 101 synergy with an approved drug, like adagrasib, in an unapproved KRAS setting offers exciting combination possibilities. The PH1 spliceosome modulator payload ADC has the potential to unlock efficacy of cancer therapeutics in cancers with oncogene dependency. We have previously demonstrated combination with AR-v7 oncogenes with enzalutamide and now KRAS oncogenes with adagrasib."</p>  <p align="justify">The data featured in the ASCO 2026 online abstract build upon Akari's previously reported AACR 2026 findings demonstrating differentiated cytotoxicity and superior potency of AKTX-101 versus current TROP2 ADCs utilizing Topoisomerase I inhibitor payloads across multiple tumor models, including bladder, lung (including KRAS G12V mutated NSCLC) and breast cancers.</p>  <p align="justify">Akari's lead program, AKTX-101, is a TROP2-targeting ADC powered by the Company's proprietary PH1 RNA spliceosome-modulating payload. Unlike traditional ADC payloads that primarily rely on microtubule or DNA-damaging mechanisms, PH1 is designed to disrupt RNA splicing within cancer cells while also activating innate and adaptive immune responses.</p>  <p align="justify">Akari has initiated IND-enabling studies for AKTX-101 and is targeting initiation of a Phase 1 first-in-human clinical trial by mid-2027.</p>  <p align="justify">For more information about the ASCO Annual Meeting 2026, please visit <a href="https://www.globenewswire.com/Tracker?data=gIF4izMTpLrMHks3VKT-XQSHYP-HH3xcVwAR78UMLIpwa5lqL7XyIUMV5Q2R2FjZtqz3p-ot-NqJhPWRBJmjlw==" rel="nofollow" target="_blank">www.asco.org</a>.</p>  <p align="justify"><strong>About Akari Therapeutics </strong></p>  <p align="justify">Akari Therapeutics is an oncology biotechnology company developing next-generation antibody drug conjugates (ADCs) with a unique payload, PH1, which targets RNA splicing. Utilizing its innovative ADC discovery platform, the Company has the ability to generate ADC candidates and optimize them based on the desired application to any antigen target of interest. Akari's lead candidate, AKTX-101, targets the Trop2 receptor on cancer cells with a proprietary linker, enabling it to deliver its novel PH1 payload directly into the tumor with minimal off-target effects. Unlike current ADCs that use microtubule inhibitors and DNA-damaging agents as their payloads, PH1 is a novel payload that is a spliceosome modulator designed to disrupt RNA splicing within cancer cells. This splicing modulation has been shown in preclinical animal models to induce cancer cell death while activating both the innate and adaptive immune systems to drive robust and durable activity. In preclinical studies, AKTX-101 has been shown to have significant activity and prolonged survival relative to ADCs with traditional payloads. Additionally, AKTX-101 has the potential to be synergistic with checkpoint inhibitors and has demonstrated prolonged survival as both a single agent and in combination with checkpoint inhibitors. The PH1 payload has also been demonstrated to be very active against cancer cells with key oncogenic drivers such as KRAS, BRAF, ARV7, FGFR3 fusions, and others. The Company has initiated IND enabling studies for AKTX-101 with a goal of starting its First-In-Human trial by mid-2027. Akari is also developing AKTX-102, an ADC candidate targeting CEACAM5 (Carcinoembryonic Antigen-related Cell Adhesion Molecule-5), a well-validated tumor antigen broadly expressed across multiple solid tumors. AKTX-102 is designed to leverage Akari's proprietary PH1 spliceosome-modulating payload and a novel antibody construct to enable differentiated tumor cell killing and immune activation.</p>  <p align="justify">For more information about the Company, please visit <a href="https://www.globenewswire.com/Tracker?data=gIF4izMTpLrMHks3VKT-XatCue4mbHS5CLA8iIPBZjb_TbVUSeyqglg7kGIuDQKaUlkGz0G1e7fvc9ScNnOpulJqi9pVoiaWlRqr8-1B_O8=" rel="nofollow" target="_blank">www.akaritx.com</a> and connect on <a href="https://www.globenewswire.com/Tracker?data=ZgUKZ4CxnPjO4r14dv1Dyl460cZnjuRCAorau-k2Y213YtyKSUcCryDh1jEydonUBJD_oGsVKnu2G9aNkV-u1Q==" rel="nofollow" target="_blank">X</a> and <a href="https://www.globenewswire.com/Tracker?data=TIPymHJywuPdPIX9lU4fO2yqP-ivA5aAvZtAGJq5zb7AK2BXXD3xKGr5D6Q_NHiTx9tDNzTeax0P92eRibCLrC_OHRDjYApRzCBjszwONXA=" rel="nofollow" target="_blank">LinkedIn</a>.</p>  <p><strong>Cautionary Note Regarding Forward-Looking Statements</strong></p>  <p align="justify">This press release includes express or implied forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, about the Company that involve risks and uncertainties relating to future events and the future performance of the Company. Actual events or results may differ materially from these forward-looking statements. Words such as "will," "could," "would," "should," "expect," "plan," "anticipate," "intend," "believe," "estimate," "predict," "project," "potential," "continue," "future," "opportunity" "will likely result," "target," variations of such words, and similar expressions or negatives of these words are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. Examples of such forward-looking statements include, but are not limited to, express or implied statements regarding the ability of the Company to advance its product candidates for the treatment of cancer and the timing of commencement of a Phase I clinical trial. These statements are based on the Company's current plans, estimates and projections. By their very nature, forward-looking statements involve inherent risks and uncertainties, both general and specific. A number of important factors, including those described in this communication, could cause actual results to differ materially from those contemplated in any forward-looking statements. Factors that may affect future results and may cause these forward-looking statements to be inaccurate include, without limitation: the Company's need for additional capital; the potential impact of unforeseen liabilities, future capital expenditures, revenues, costs, expenses, earnings, synergies, economic performance, indebtedness, financial condition and losses on the future prospects, business and management strategies for the management, expansion and growth of the business; risks related to global as well as local political and economic conditions, including interest rate and currency exchange rate fluctuations; potential delays or failures related to research and/or development of the Company's programs or product candidates; risks related to any loss of the Company's patents or other intellectual property rights; any interruptions of the supply chain for raw materials or manufacturing for the Company's product candidates, including as a result of potential tariffs; the nature, timing, cost and possible success and therapeutic applications of product candidates being developed by the Company and/or its collaborators or licensees; the extent to which the results from the research and development programs conducted by the Company, and/or its collaborators or licensees may be replicated in other studies and/or lead to advancement of product candidates to clinical trials, therapeutic applications, or regulatory approval; uncertainty of the utilization, market acceptance, and commercial success of the Company's product candidates; risks related to competition for the Company's product candidates; and the Company's ability to successfully develop or commercialize its product candidates. While the foregoing list of factors presented here is considered representative, no list should be considered to be a complete statement of all potential risks and uncertainties. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Company's filings with the SEC, copies of which may be obtained from the SEC's website at <a href="http://www.sec.gov" title="www.sec.gov">www.sec.gov</a>. The Company assumes no, and hereby disclaims any, obligation to update the forward-looking statements contained in this press release except as required by law.</p>  <p align="justify"><strong>Investor Relations Contact </strong></p>  <p align="justify">JTC Team, LLC <br></br>Jenene Thomas <br></br>908-824-0775 <br></br><u><a href="https://www.globenewswire.com/Tracker?data=saY9W3F52ql8nFDdCcNnU2fK_oOQyTZByCQNmhEQ_ilMebn3q889Cc7HUHYNRCUIY8EAUDXt3oCXs7eB_-wfpw==" rel="nofollow" target="_blank">AKTX@jtcir.com</a></u></p> <img alt="" class="__GNW8366DE3E__IMG" src="https://www.globenewswire.com/newsroom/ti?nf=OTcyNTAxMyM3NjE2NjEyIzIwMjAyNjM="></img> <br></br><img alt="" src="https://ml.globenewswire.com/media/NDc0OGE4ZTUtOTQ4YS00OTAwLWIyNmUtNzdlYWQ4MTE2N2UyLTEwMzE4MzUtMjAyNi0wNS0yMS1lbg==/tiny/Akari-Therapeutics-Plc.png" referrerpolicy="no-referrer-when-downgrade"></img><p><a href="https://www.globenewswire.com/NewsRoom/AttachmentNg/8d978f50-07a9-40a3-be69-45f51ccd94d9"><img src="https://ml.globenewswire.com/media/8d978f50-07a9-40a3-be69-45f51ccd94d9/small/akari-logo-1-jpg.jpg" border="0" width="150" height="130" alt="Primary Logo"></img></a></p>

Akari Therapeutics announced positive preclinical findings for AKTX-101 at ASCO 2026, highlighting synergistic activity with KRAS inhibitors in treating difficult pancreatic cancer models. This differentiation from conventional ADCs opens new therapeutic possibilities and extends the application of RNA splicing therapies. Investors should monitor subsequent clinical developments as AKTX-101 progresses towards human trials.

akari-therapeutics-reports-breakthrough-preclinical-data-demonstrating-synergistic-activity-of-aktx-101-with-kras-inhibition-in-kras-mutated-pancreatic-cancer-models

Akari Therapeutics Reports Breakthrough Preclinical Data Demonstrating Synergistic Activity of AKTX-101 with KRAS Inhibition in KRAS-Mutated Pancreatic Cancer Models

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