NEEDHAM, Mass., Aug.  03, 2026  (GLOBE NEWSWIRE) -- Candel Therapeutics, Inc. (Candel or the Company) (NASDAQ:CADL), a clinical-stage biopharmaceutical company focused on developing multimodal immunotherapies to improve

CADL

Candel Therapeutics to Present Extended Data from Phase 3 Results of Aglatimagene Besadenovec at ASTRO 2026

CADL to present ASTRO poster on aglatimagene, potential catalyst

<section class="insight" data-version="1">
  <section data-block="information">
    <h3>Information</h3>
    <p>NEEDHAM, Mass., Aug.  03, 2026  (GLOBE NEWSWIRE) -- Candel Therapeutics, Inc. (Candel or the Company) (NASDAQ:CADL), a clinical-stage biopharmaceutical company focused on developing multimodal immunotherapies to improve</p>
  </section>

  <section data-block="ai-summary-paragraph">
    <h3>AI Summary</h3>
    <p>Candel Therapeutics announced an ASTRO 2026 poster on aglatimagene besadenovec for localized prostate cancer, presented Sept 29 by CSO Francesca Barone. The abstract centers on immune activation assessed by digital pathology, underscoring potential efficacy signals. FDA Fast Track and Orphan Drug designations support development, with a likely near-term catalyst from data readouts or regulatory milestones that could influence CADL&#039;s valuation.</p>
  </section>

  <section data-block="ai-summary-bullets">
    <h3>Key Points</h3>
    <ul><li>CADL to present ASTRO poster on aglatimagene, potential catalyst.</li><li>Abstract: Quantitative Digital Pathology Defines Immune Activation; presenter Francesca Barone.</li><li>FDA granted Fast Track and Orphan Drug Designations for aglatimagene across indications.</li><li>Linoserpaturev HSV platform lead; enLIGHTEN discovery platform overview.</li></ul>
  </section>

  <section data-block="companies-mentioned">
    <h3>Companies Mentioned</h3>
    <ul><li><strong>Candel Therapeutics, Inc. (CADL)</strong>: Primary subject; ASTRO poster and clinical programs aglatimagene and linoserpaturev; potential catalyst.</li></ul>
  </section>

  <section data-block="category">
    <h3>Corporate Developments</h3>
    <p>Category: Corporate Developments. The announcements reflect ongoing clinical development milestones and regulatory designations, which can influence CADL&#039;s valuation if perceptions shift towards probability of approval or meaningful therapeutic benefit.</p>
  </section>

  <section data-block="market-moving">
    <h3>Market-Moving</h3>
    <ul><li>ASTRO poster acceptance may spur near-term trading interest in CADL.</li><li>FDA designations for aglatimagene support sentiment on the program.</li><li>No trial readouts disclosed at ASTRO; data-driven moves depend on results.</li></ul>
  </section>

  <section data-block="key-facts">
    <h3>Key Facts</h3>
    <ul><li>Abstract title: Quantitative Digital Pathology Defines Immune Activation Following Aglatimagene Besadenovec Immunotherapy in Localized Prostate Cancer.</li><li>Presenter: Francesca Barone, MD, PhD, CSO, Candel Therapeutics.</li><li>Session Date/Time: Sept 29, 2026; 2:15 PM - 3:30 PM ET.</li><li>Location: ASTRO 2026 poster hall, Boston, MA.</li></ul>
  </section>

  <section data-block="trading-thesis">
    <h3>Trading Thesis</h3>
    <p>Positive ASTRO data or regulatory catalysts could lift CADL in the near term (months).</p>
  </section>
</section>


<link type="text/css" rel="stylesheet" href="https://www.globenewswire.com/styles/gnw_nitf.css"></link><p align="justify">NEEDHAM, Mass., Aug.  03, 2026  (GLOBE NEWSWIRE) -- Candel Therapeutics, Inc. (Candel or the Company) (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/CADL">CADL</a>), a clinical-stage biopharmaceutical company focused on developing multimodal immunotherapies to improve disease outcomes for patients with cancer, today announced that an abstract was accepted for poster presentation at the 2026 American Society for Radiation Oncology (ASTRO) Annual Meeting, taking place September 26-30, 2026, in Boston, MA.</p>    <p align="justify"><strong>Aglatimagene besadenovec – Localized Prostate Cancer </strong></p>    <ul type="disc"><li style="margin-bottom:8pt;"><strong>Abstract Title:</strong> Quantitative Digital Pathology Defines Immune Activation Following Aglatimagene Besadenovec Immunotherapy in Localized Prostate Cancer</li><li style="margin-bottom:8pt;"><strong>Presenter:</strong> Francesca Barone, MD, PhD, Chief Scientific Officer, Candel Therapeutics, Needham, MA</li><li style="margin-bottom:8pt;"><strong>Session Title:</strong> PQA 06: Genitourinary Cancer, Gynecological Cancer and Health Care Access and Engagement</li><li style="margin-bottom:8pt;"><strong>Session Date/Time:</strong> Tuesday, September 29, 2026; 2:15 PM - 3:30 PM ET</li><li style="margin-bottom:8pt;"><strong>Location:</strong> Poster Hall – Exhibit Hall A, Thomas M. Menino Convention &amp; Exhibition Center, Boston, MA <br></br><br></br></li></ul>    <p><strong>About Candel Therapeutics</strong></p>    <p align="justify">Candel is a clinical-stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical-stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. Aglatimagene besadenovec (aglatimagene) is the lead product candidate from the adenovirus platform. The Company completed successful phase 2a clinical trials of aglatimagene in non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC), and a pivotal, placebo-controlled, phase 3 clinical trial of aglatimagene in localized prostate cancer, conducted under a Special Protocol Assessment agreed with the U.S. Food and Drug Administration (FDA) and published in <a href="https://www.globenewswire.com/Tracker?data=95-3vFfKWTSiur4kcEOMuQd_I1WJrOrqiNO2ZN83tRDq7a-AqQVc9webIirx9-VARqI9PdJngRoqHiGMm-othYUjNScNjE_cHeZLWINz4dVPDx1EuiBPw-fw14OVMGrQr0Di8eDCcbJ-nJhg4tpQj_YM5NWljoa1ie4Z84kDpQZDAfArnavqVxgY1WHtSv6vQJaLaH8m6eGq3nLOVAzEvwo8hDofEJs4uT-8B20hexc2ROIGALi2u0LvwhPxghtDJjeIqME_xKTvxkWQf-SWl_6lWqsethBcn-hPsJxUv2bQsg9NeN1UU-qRlnUgW5oJ2BwtO9M2zndKHalh68JI0E2jcyixc0AIdUH0GURASrTka_kkkdxZPnnpUr4_NMtd" rel="nofollow" target="_blank"><em>The Lancet Oncology</em></a>. The FDA also granted Fast Track Designation and Regenerative Medicine Advanced Therapy Designation to aglatimagene for the treatment of newly diagnosed localized prostate cancer in patients with intermediate- to high-risk disease, Fast Track Designation in NSCLC, and both Fast Track Designation and Orphan Drug Designation to aglatimagene for the treatment of PDAC.</p>    <p align="justify">Linoserpaturev is the lead product candidate from the HSV platform and is currently in an ongoing phase 1b clinical trial in recurrent high-grade glioma, evaluating the effects of repeat linoserpaturev injections. Initial results were published in <a href="https://www.globenewswire.com/Tracker?data=8-THgYnQQgo0RdXZKLR__rRVo2jbhju9R7ATVV6UOIvm_1w0u7FSdysGXDXhWcQ_JJXR7gvtMWdjRYGvsKlMW4NGtl6rlZiLmqZqMCLI6-r8vx28BESaL8EuePnLiuDGn6gMu6d90ivr-7X6fWHCmBzzIFBfwmYA5oGqPI823ppPAs5ATvHZG_hBJVvwORLPQzJlwl4dM1ntlzJgKMfIq78VXgdUQIBAWSVqlw5_NJxN7AMo6oXcmf_-7AUuvQ9k60RMRhvZA0U0sTeGOdie6WBWmFDLqhlaEtZwXr8ap78i7wLkVY4HBDT3IE5MPL909dikC9MptyH8eRmwaCGm8c8Rb9dWBu0QMSwNCxmPqPIKrMe6Ird6jtpBaDnqRXPR9kliPdggJuAg43Z4ioCUYb1f_1eX-UpAL8BVXL_19mLohYPzQ4RB4TeLbQYvpn3hBTRDqnKTIOuwGJXERqZ6qDdJ3R0Mp2fuKhHUDiM78mU=" rel="nofollow" target="_blank"><em>Nature</em></a> and <a href="https://www.globenewswire.com/Tracker?data=ioFocNSOzbgb-WZdK2yU8QOdl66KHW2FjeXcyfAkUrI5DrTk3h-Z1I3pVcZZQ8mT4D-0jZeAqsUjGjSwgaDzo3hkR5Ha5wzzu10LEIrIiiaGjuiVuTWquksIMHHMnA643g9vNyG_h5rPt352h2PCBfr5TIM8ZRmQKxxhJ92em_fVrwdq9q9mSMEeqwjSjQ1rLca2qE2t3Jbt_i3NACV_WTauOsHiGkcHKp_XF4c_UhcaEkWGCPcM-3uZznc_vxUFCAcnc7MeRsMoWjzW3-k2Qk2XXrqFTOd0gjBG-2I635iOIAyvZgK7iC0q8ETnhNwz5eiJaQSccu2XW5U5jgVPS2pvdIDSsE-2lff4KyF8zIVSRG9cCjkCVeBgmTNJ33DErVZQQ8lDI71Zqc06gP7-YBHVDFy4nw3BDNOLFEKC58OPLVrRITubGQSgnmt5YDLwtK7AB9mcR8JJ7-GhZAwupQgNkYjX6dabDC_AKN4ux__5awtYW1e4cuTYkTG-mm_XBVxzanhhgzm4XH-D7V3Gy6J7iPqwUNnyoT40Kdv3XmbM3JUifZprm44vtWM3MPQeot-62vdQJxV5XINDRhLOZt6586-ZyVxpbrhij3KCtYCzbzJD-b_Nn8Jdd-8wLjiiLzTdZqxpbxpB8bE0hjd_lg==" rel="nofollow" target="_blank"><em>Science Translational Medicine</em></a> and linoserpaturev received Fast Track Designation and Orphan Drug Designation from the FDA. Finally, Candel’s enLIGHTEN&#x2122; Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.</p>    <p align="justify">For more information about Candel, visit: <a href="https://www.globenewswire.com/Tracker?data=OXxQyYx8vQI6fXx52Mlxsz-od2PVy6JIxTOxhLbfvUymdAY9LAQvxyuI_nv__qLbftFYTSh5CyGsVEcgj6MQ5eb8-NjDQmnjJLIys9ctDpI=" rel="nofollow" target="_blank">www.candeltx.com</a>.</p>    <p align="justify"><strong>Forward-Looking Statements</strong></p>    <p align="justify">This press release includes certain disclosures that contain "forward-looking statements," within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of current and future development programs; expectations regarding the therapeutic benefit of the Company’s platforms, including the ability of its platforms to improve overall survival and/or disease-free survival of patients living with difficult-to-treat, solid tumors; and expectations regarding the potential benefits conferred by regulatory designations. The words "may," "will," "could," "would," "should," "expect," "plan," "anticipate," "intend," "believe," "estimate," "predict," "project," "potential," "continue," "target" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management’s current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Company’s programs; that final data from the Company’s preclinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Company’s ability to efficiently discover and develop product candidates; the Company’s ability to obtain and maintain regulatory approval of product candidates; the Company’s ability to maintain its intellectual property; the implementation of the Company’s business model, including strategic plans for the Company’s business and product candidates; the impact of the Company’s existing and any future indebtedness on its ability to operate its business; the Company’s ability to access any future tranches under its debt facility and to comply with all of its obligations thereunder; and other risks identified in the Company’s filings with the U.S. Securities and Exchange Commission (SEC), including the Company’s most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q for the quarter ended March 31, 2026, each as filed with the SEC and any subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions, or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Company’s views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.</p>    <p><strong>Investor Contact</strong><br></br>Theodore Jenkins<br></br>Vice President, Investor Relations, and Business Development<br></br>Candel Therapeutics, Inc.<br></br><a href="https://www.globenewswire.com/Tracker?data=TcsTqtqUndul1kYgUoF2X0K7LsSlnmykRTLYQzSxEc7hWTq-MUWk2vC59xZvxwRUGGC0q9Tv6TbgOVR38e-eh9eTMl9GK7Oeu8bRoD-xDpU=" rel="nofollow" target="_blank">tjenkins@candeltx.com</a></p>    <p><strong>Media Contact</strong><br></br>Ben Shannon<br></br>ICR Healthcare <br></br><a href="https://www.globenewswire.com/Tracker?data=0lm9qlvItG5BKgf9nM3NXKWye2Kaug6qHWKwktLSttGhON0T3jYMlJd6YK3AadiETL9pzzg3hcO2WTrPCDatvgxUneBIkVm_IMUop06iR_D3vCF-j2_bWaDdN9WGb3iu" rel="nofollow" target="_blank">CandelPR@icrhealthcare.com</a></p> <img alt="" class="__GNW8366DE3E__IMG" src="https://www.globenewswire.com/newsroom/ti?nf=OTgwMTg4NiM3NzUzODExIzIxMDAxNTQ="></img> <br></br><img alt="" src="https://ml.globenewswire.com/media/MDdhOTE4NzYtMDE5My00MTE3LWEwMmUtZWU3ZmFiNWQ0YTc1LTExMTE3MjUtMjAyNi0wOC0wMy1lbg==/tiny/Candel-Therapeutics-Inc.png" referrerpolicy="no-referrer-when-downgrade"></img><p><a href="https://www.globenewswire.com/NewsRoom/AttachmentNg/8b82e1e3-4a67-4472-a7c8-05f9d24c9bb0"><img src="https://ml.globenewswire.com/media/8b82e1e3-4a67-4472-a7c8-05f9d24c9bb0/small/candel-logo-fullcolor-4-png.png" border="0" width="150" height="68" alt="Primary Logo"></img></a></p>

Candel Therapeutics announced an ASTRO 2026 poster on aglatimagene besadenovec for localized prostate cancer, presented Sept 29 by CSO Francesca Barone. The abstract centers on immune activation assessed by digital pathology, underscoring potential efficacy signals. FDA Fast Track and Orphan Drug designations support development, with a likely near-term catalyst from data readouts or regulatory milestones that could influence CADL's valuation.

News insight

Candel Therapeutics to Present Extended Data from Phase 3 Results of Aglatimagene Besadenovec at ASTRO 2026

AI summary

Sentiment rationale

Key facts

Corporate Developments