CytoSorbents Reports Third Quarter 2025 Financial Results and Provides Business Update

Third quarter 2025 revenue of $9.5 million, up 10% year-over-year Amended credit agreement with Avenue Capital Group which strengthens our balance sheet with an additional $2.5 million of cash, and extends the interest only-period through December 31, 2026, with an additional $2.5 million available and an additional extension of the interest-only period to June 30, 2027 with DrugSorb-ATR FDA marketing approval Implemented Workforce and Cost Reduction Program to accelerate path to cash-flow breakeven to Q1 2026 Submitted DrugSorb™-ATR De Novo pre-submission package to FDA, with meeting expected in Q4 2025 or early Q1 2026, followed by planned submission of new De Novo application in Q1 2026, and anticipated regulatory decision mid-2026 , /PRNewswire/ -- CytoSorbents Corporation (NASDAQ: CTSO), a leader in the treatment of life-threatening conditions in the intensive care unit and cardiac surgery using blood purification, today reported financial results for the third quarter ended September 30, 2025, and recent business highlights. Third Quarter 2025 Financial Results Revenue was $9.5 million, an increase of 10%, or 4% on a constant currency basis, compared to $8.6 million in Q3 2024. Growth was led by record performance in our distributor territories and near-record performance in direct sales outside Germany. Gross margin in Q3 2025 was 70% compared to 61% in Q3 2024. Last year's gross margin was affected by a planned production slow-down to rebalance inventory and a temporary manufacturing issue that was resolved during Q3 2024. Operating loss improved to $2.9 million, compared to $4.8 million in Q3 2024 due to improved gross margins and lower operating expenses Net loss was $3.2 million or $0.05 per share, compared to a net loss of $2.8 million or $0.05 per share in Q3 2024. Adjusted net loss improved to $2.6 million or $0.04 per share, compared to an adjusted net loss of $4.5 million or $0.08 per share in Q3 2024. Adjusted EBITDA loss improved to $2.0 million compared to a loss of $3.6 million in Q3 2024. Total cash, cash equivalents, and restricted cash of $9.1 million on September 30, 2025, compared to $11.7 million as of June 30, 2025, reflecting net operating cash burn in the quarter of $2.6 million. Proforma cash, cash equivalents, and restricted cash was $11.6 million on September 30, 2025, as if the additional $2.5 million term loan capital made available through the amended credit agreement with Avenue Capital Group were drawn on September 30, 2025. Total proforma debt drawn under the agreement as of September 30, 2025, is $17.5 million. "We are pleased with our third quarter results led by record sales in our distributor territories, strong sales in our other direct markets, and improved operating margins and cash efficiencies across the company," stated Dr. Phillip Chan, Chief Executive Officer of CytoSorbents. "This strong sales growth was partially offset by a decline in our direct German market where we continue our proactive reorganization of our commercial team and selling approach which we believe will lead to improved performance and execution in 2026." Workforce and Cost Reduction Program Expected to Accelerate Q1 2026 Cash Flow Breakeven Today, the Company announced the implementation of a strategic Workforce and Cost reduction plan to further reduce costs, optimize operations, and accelerate the path to cash-flow profitability. This initiative follows a comprehensive internal review of its cost structure and operating model. As part of the strategic plan, CytoSorbents reduced its workforce by approximately 10%, reduced and realigned production and operating expenses, and now expects to reach operating cash flow break-even in the first quarter of 2026. The Company expects to record a charge of up to $900,000 that will include severance and other charges related to the restructuring. The estimated costs that the Company expects to incur, and the timing thereof, are subject to a number of assumptions, and actual amounts may differ materially. Amended Credit Agreement Strengthens Balance Sheet and Extends Interest-only PeriodToday, the Company announced that it has amended its prior credit agreement with Avenue Capital Group effective November 13, 2025. The amendment provides immediate funding of an additional $2.5 million in term loan capital and an extension of the interest-only period to December 31, 2026 (from July 1, 2026), followed by equal monthly installments of principal plus accrued and unpaid interest until maturity on July 1, 2027. The Amendment requires that the Company maintain certain operating cash burn targets only until U.S. FDA marketing approval of DrugSorb-ATR is achieved. The Company will have access to an additional $2.5 million in term loan capital with a further six-month extension of the interest-only period to the July 1, 2027 maturity date upon the U.S. FDA approval of DrugSorb-ATR in 2026. Under the terms of the amendment, the Company issued additional warrants to Avenue Capital Group to purchase 1,428,571 shares of the Company's common stock for cash at the exercise price of $0.70, which expire on November 13, 2030. The number of warrants and exercise price are fixed. DrugSorb™-ATR Regulatory UpdatesOn September 16, 2025, the Company announced plans to submit a new De Novo application for DrugSorb-ATR to the U.S. FDA. This decision followed an FDA appeal meeting and final determination that upheld the prior denial of the original application. Notably, the FDA raised no concerns regarding device safety but requested additional information to support the Company's desired label indication. The new De Novo submission will include analyses of real-world data demonstrating DrugSorb-ATR's effectiveness in clinical practice - data that were not available at the time of the original filing and therefore not eligible for inclusion in the prior review. The Company believes these new data underscore DrugSorb-ATR's strong clinical performance and reinforce its favorable benefit-to-risk profile, particularly when combined with the comprehensive clinical evidence previously submitted. To advance this process, the Company submitted a pre-submission meeting request with supporting documentation to the FDA on November 7, 2025. A formal meeting with the Agency is expected in late Q4 2025 or early 2026 to confirm the requirements for the new application, followed by the formal De Novo submission in Q1 2026. A regulatory decision is anticipated by mid-2026, following the typical 150-day review period. Based on discussions with the FDA, the review is expected to focus solely on the remaining open items from the initial submission and may be expedited under the device's FDA Breakthrough Device Designation, which allows for priority and interactive review. Dr. Chan continued, "We are pleased with the progress we are making on key strategic initiatives including strong sales in our existing core business, gross margins of over 70%, progress toward DrugSorb-ATR approval and launch in the US, and the expectation to bring the Company to cash flow breakeven in the first quarter. This progress is further supported by the amendment of our credit agreement which we believe provides sufficient liquidity and flexibility to continue supporting our strategic growth initiatives. We appreciate the partnership with our lender – Avenue Capital Group – and look forward to continuing to execute our strategy." "We are happy to restructure the existing loan facility and provide more capital to CytoSorbents. We have been very impressed with their OUS revenue growth and how they have been impacting patients' lives and want to be strong capital partners," stated Chad Norman, Sr. Portfolio Manager, Avenue Capital Group. A Wealth of New Clinical DataMeanwhile, recent clinical data publications and presentations continue to reinforce the positive clinical impacts our therapies are having around the world. Select recent examples include: On September 10, 2025, in commemoration of Sepsis Awareness Month and World Sepsis Day, Dr. Chan hosted a special webinar featuring the clinical insights of leading international critical care experts entitled "Turning the Tide on Sepsis and Septic Shock: Real World Insights with CytoSorb". This webinar highlighted CytoSorb's broad mechanisms of action in helping to manage the complex pathophysiology of sepsis and septic shock, with a focus on controlling deadly inflammation, stabilizing organ function, promoting a reversal of capillary leak, and enabling fluid removal. Recent exciting publications reinforce the importance of early and intensive CytoSorb treatment in septic shock, particularly the retrospective study of 175 septic shock patients (Berlot, et al. 2025), while the first meta-analysis of 744 patients with septic shock from Charité Berlin Hospital demonstrated that CytoSorb usage in these patients led to significant reductions in both in-hospital and 28-30-day mortality (Steindl, et al. 2025). Access the entire webinar here, or the white paper here. At the European Association for Cardio-Thoracic Surgery (EACTS) Annual Meeting in October, Prof. Richard Whitlock (McMaster University) presented the first randomized controlled trial data on the "Intraoperative Removal of Direct Oral Anticoagulants in Patients Undergoing Urgent Cardiothoracic Surgery" where intraoperative use of DrugSorb™-ATR in cardiac surgery significantly reduced levels of direct oral anticoagulants (DOACs), such as Eliquis® (apixaban, Pfizer/Bristol Myers Squibb) and Xarelto® (rivaroxaban, Janssen/Bayer), compared to sham controls. This supports the notion that our technology can be a "one-size fits all" countermeasure for different classes of blood thinners in cardiac surgery. In a presentation titled, "Dual Antiplatelet Therapy (DAPT) and Urgent CABG in Acute Coronary Syndrome (ACS): Impact of P2Y12 Inhibitor Choice & Intraoperative Hemoadsorption on Perioperative Bleeding: Comparative Real-World Analysis," Professor Matthias Thielmann (Westerman Heart & Vascular Center) presented compelling real-world data from a real-world study demonstrating that among heart attack patients undergoing urgent CABG, combining dual antiplatelet therapy (aspirin + ticagrelor) with intraoperative use of CytoSorb® reduces severe bleeding complications compared with patients treated with aspirin + Plavix (clopidogrel) without CytoSorb. Dr. Chan concluded, "With a rapidly expanding foundation of clinical evidence that now encompasses hundreds of peer-reviewed publications, real-world data, and compelling success stories, CytoSorbents' broad-spectrum blood purification technology continues to advance as a powerful tool for removing harmful substances and redefine how some of the most complex and life-threatening conditions are treated. We were especially pleased with the strong response to our World Sepsis Day Global Webinar on September 10th, which underscored the critical and evolving role of early, intensive use of CytoSorb® alongside traditional antibiotic therapy in managing sepsis and septic shock. Looking ahead, we remain committed to expanding our clinical programs across all applications to further improve outcomes for patients, and to support the healthcare workers around the world who care for them." Third Quarter 2025 Earnings Conference Call CytoSorbents' management will host a live conference call, presentation webcast, and a question-and-answer session with the following information: Date: Thursday November 13, 2025Time: 4:30 PM ETLive webcast link:https://app.webinar.net/g7AGWegQ613 It is recommended that participants join approximately 10 minutes prior to the start of the call. An archived recording of the conference call will be available under the Investor Relations section of the Company's website at https://ir.cytosorbents.com/ About Non-GAAP Financial Measures To supplement our condensed consolidated financial statements, we use the non-GAAP financial measures of EBITDA, which measures earnings before interest, income taxes, depreciation and amortization, and Adjusted EBITDA which further excludes non-cash stock compensation expense, and gain or loss of foreign exchange translation. We also use the non-GAAP financial measures of Adjusted Net Income or Loss and Adjusted Net Income or Loss Per Share which excludes non-cash stock compensation expense and gain or loss of foreign exchange translation from Net Loss and Net Loss Per Share, respectively. These non-GAAP measures are not based on any comprehensive set of accounting rules or principles and should not be considered a substitute for, or superior to, financial measures calculated in accordance with GAAP and may be different from non-GAAP measures used by other companies. In addition, these non-GAAP measures should be read in conjunction with our financial statements prepared in accordance with GAAP. The reconciliations of the non-GAAP measures to the most directly comparable financial measures calculated and presented in accordance with GAAP should be carefully evaluated. We use these non-GAAP financial measures for financial and operational decision-making and as a means to evaluate period-to-period comparisons. We believe that these non-GAAP financial measures provide meaningful supplemental information regarding our performance and that both management and investors benefit from referring to these non-GAAP financial measures in assessing our performance and when planning, forecasting, and analyzing future periods. We believe these non-GAAP financial measures are useful to investors because (1) they allow for greater transparency with respect to key metrics used by management in its financial and operational decision-making and (2) they are used by investors and the analyst community to help them analyze the performance of our business, the Company's cash available for operations, and the Company's ability to meet future capital expenditure and working capital requirements. For a reconciliation of non-GAAP financial measures to the most comparable GAAP measure, see the reconciliation included in the financial tables. All non-GAAP adjustments are presented pre-tax. About CytoSorbents Corporation (NASDAQ: CTSO) CytoSorbents Corporation is a leader in the treatment of life-threatening conditions in the intensive care unit and cardiac surgery through blood purification. CytoSorbents' proprietary blood purification technologies are based on biocompatible, highly porous polymer beads that can actively remove toxic substances from blood and other bodily fluids by pore capture and surface adsorption. Cartridges filled with these beads can be used with standard blood pumps already in the hospital (e.g. dialysis, continuous renal replacement therapy or CRRT, extracorporeal membrane oxygenation or ECMO, and heart-lung machines), where blood is repeatedly recirculated outside the body, through our cartridges where toxic substances are removed, and then back into the body. CytoSorbents' technologies are used in a number of broad applications. Specifically, two important applications are 1) the removal of blood thinners during and after cardiothoracic surgery to reduce the risk of severe bleeding, and 2) the removal of inflammatory agents and toxins in common critical illnesses that can lead to massive inflammation, organ failure and patient death. The breadth of these critical illnesses includes, for example, sepsis, burn injury, trauma, lung injury, liver failure, cytokine storm and cytokine release syndrome, and pancreatitis as well as the removal of liver toxins that accumulate in acute liver dysfunction or failure, and the removal of myoglobin in severe rhabdomyolysis that can otherwise lead to renal failure. In these diseases, the risk of death can be extremely high, and there are few, if any, effective treatments. CytoSorbents' lead product, CytoSorb®, is approved in the European Union and distributed in over 70 countries worldwide, with nearly 300,000 devices used cumulatively to date. CytoSorb was originally launched in the European Union under CE mark as the first cytokine adsorber. Additional CE mark extensions were granted for bilirubin and myoglobin removal in clinical conditions such as liver disease and trauma, respectively, and for ticagrelor and rivaroxaban removal in cardiothoracic surgery procedures. CytoSorb has also received FDA Emergency Use Authorization in the United States for use in adult critically ill COVID-19 patients with impending or confirmed respiratory failure. CytoSorb is not yet approved or cleared in the United States. In the U.S. and Canada, CytoSorbents is developing the DrugSorb™-ATR antithrombotic removal system, an investigational device based on an equivalent polymer technology to CytoSorb, to reduce the severity of perioperative bleeding in high-risk surgery due to blood thinning drugs. It has received two FDA Breakthrough Device Designations: one for the removal of ticagrelor and another for the removal of the direct oral anticoagulants (DOAC) apixaban and rivaroxaban in a cardiopulmonary bypass circuit during urgent cardiothoracic surgery. The Company is actively pursuing regulatory approval of DrugSorb-ATR with the U.S. FDA and will pursue regulatory approval with Health Canada with better visibility from the FDA. DrugSorb-ATR is not yet granted or approved in either the U.S. or Canada. The Company has numerous marketed products and products under development based upon this unique blood purification technology protected by many issued U.S. and international patents and registered trademarks, and multiple patent applications pending, including ECOS-300CY®, CytoSorb-XL™, HemoDefend-RBC™, HemoDefend-BGA™, VetResQ®, K+ontrol™, DrugSorb™, ContrastSorb, and others. For more information, please visit the Company's website at https://ir.cytosorbents.com/ and follow us on Facebook and X and LinkedIn. Forward-Looking Statements This press release includes forward-looking statements intended to qualify for the safe harbor from liability established by the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, statements about our plans, objectives, future targets and outlooks for our business, representations and contentions, and the outcome of our regulatory submissions, and are not historical facts and typically are identified by use of terms such as "may," "should," "could," "expect," "plan," "anticipate," "believe," "estimate," "predict," "potential," "continue" and similar words, although some forward-looking statements are expressed differently. You should be aware that the forward-looking statements in this press release represent management's current judgment and expectations, but our actual results, events and performance could differ materially from those in the forward-looking statements. Factors which could cause or contribute to such differences include, but are not limited to, our restructuring of our direct sales team and strategy in Germany, ability to successfully obtain U.S. FDA and Health Canada marketing authorization or approval, our ability to complete our strategic workforce and cost reduction plan to reduce costs, optimize operations, and achieve cash-flow break-even in the first quarter of 2026, our ability to appropriately finance the Company, and the risks discussed in our Annual Report on Form 10-K, filed with the SEC on March 31, 2025, as updated by the risks reported in our Quarterly Reports on Form 10-Q, and in the press releases and other communications to shareholders issued by us from time to time which attempt to advise interested parties of the risks and factors which may affect our business. We caution you not to place undue reliance upon any such forward-looking statements. We undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise, other than as required under the Federal securities laws. Please Click to Follow Us on Facebook and X and LinkedIn U.S. Company Contact: Peter J. Mariani, Chief Financial Officer305 College Road EastPrinceton, NJ 08540[email protected] Investor Relations Contact:Aman Patel, CFA & Adanna G. Alexander, PhDICR Healthcare [email protected] PART I — FINANCIAL INFORMATION Item 1. Financial Statements. CYTOSORBENTS CORPORATION CONDENSED CONSOLIDATED BALANCE SHEETS (in thousands, except share data) September 30, December 31, 2025 2024 (unaudited) ASSETS Current Assets: Cash and cash equivalents $ 7,536 $ 3,280 Restricted cash, current — 5,000 Accounts receivable, net of allowances of $134 and $158 as of September 30, 2025 and December 31, 2024, respectively 7,427 7,320 Inventories 4,002 2,733 Prepaid expenses and other current assets 2,348 3,271 Total current assets 21,313 21,604 Property and equipment - net 8,193 9,002 Restricted cash 1,522 1,484 Right-of-use asset 11,075 11,511 Other assets 3,647 3,771 Total assets $ 45,750 $ 47,372 LIABILITIES AND STOCKHOLDERS' EQUITY Current Liabilities: Accounts payable $ 3,035 $ 3,340 Accrued expenses and other current liabilities 6,559 6,032 Lease liability – current portion 518 453 Total current liabilities 10,112 9,825 Lease liability, net of current portion 12,051 12,444 Long-term debt 14,567 13,996 Total liabilities 36,730 36,265 Commitments and Contingencies Stockholders' equity Preferred Stock, par value $0.001, 5,000,000 shares authorized; no shares issued and outstanding as of September 30, 2025 and December 31, 2024 — — Common Stock, par value $0.001, 100,000,000 shares authorized as of September 30, 2025 and December 31, 2024; 62,794,305 and 54,830,146 shares issued and outstanding as of September 30, 2025 and December 31, 2024, respectively 63 55 Additional paid-in capital 319,511 310,809 Accumulated other comprehensive income (loss) (3,844) 4,252 Accumulated deficit (306,710) (304,009) Total stockholders' equity 9,020 11,107 Total liabilities and stockholders' equity $ 45,750 $ 47,372 See accompanying notes to condensed consolidated financial statements CYTOSORBENTS CORPORATION CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (UNAUDITED) (in thousands, except share and per share data) Three Months Ended September 30, Nine Months Ended September 30, 2025 2024 2025 2024 (Unaudited) (Unaudited) (Unaudited) (Unaudited) Revenue $ 9,485 $ 8,613 $ 27,829 $ 26,444 Cost of goods sold 2,819 3,357 8,142 7,812 Gross profit 6,666 5,256 19,687 18,632 Operating expenses Research and development, net of grant income 918 1,826 3,842 5,592 Selling, general and administrative 8,610 8,260 26,209 26,097 Total operating expenses 9,528 10,086 30,051 31,689 Loss from operations (2,862) (4,830) (10,364) (13,057) Other income (expense) Interest expense, net (645) (588) (1,866) (775) Gain (loss) on foreign currency transactions (64) 2,650 9,128 680 Total other income (expense), net (709) 2,062 7,262 (95) Loss before benefit from income taxes (3,571) (2,768) (3,102) (13,152) Benefit from income taxes 401 — 401 — Net loss $ (3,170) $ (2,768) $ (2,701) $ (13,152) Basic and diluted net loss per common share $ (0.05) $ (0.05) $ (0.04) $ (0.24) Weighted Average Shares of Common Stock Outstanding Basic and diluted 62,753,959 54,453,006 62,038,902 54,340,583 Other comprehensive income (loss): Foreign currency translation adjustment, net of tax 116 (2,330) (8,096) (686) Comprehensive loss $ (3,054) $ (5,098) $ (10,797) $ (13,838) See accompanying notes to condensed consolidated financial statements. CYTOSORBENTS CORPORATION CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY (UNAUDITED) (in thousands, except share data) Accumulated Additional Other Common Stock Paid-In Comprehensive Accumulated Stockholders' Shares Par Value Capital Income (Loss) Deficit Equity Balance as of June 30, 2025 (unaudited) 62,610,376 $ 63 $ 319,023 $ (3,960) $ (303,540) $ 11,586 Stock-based compensation 183,929 — 488 — — 488 Foreign translation adjustment — — — 116 — 116 Net loss — — — — (3,170) (3,170) Balance at September 30, 2025 (unaudited) 62,794,305 $ 63 $ 319,511 $ (3,844) $ (306,710) $ 9,020 Balance at December 31, 2024 54,830,146 $ 55 $ 310,809 $ 4,252 $ (304,009) $ 11,107 Stock-based compensation 297,160 1 1,878 — — 1,879 Issuance of common stock and warrants from rights offerings, net of fees incurred 6,249,791 6 5,386 — — 5,392 Issuance of common stock from exercise of warrants 1,417,208 1 1,438 — — 1,439 Foreign translation adjustment — — — (8,096) — (8,096) Net loss — — — — (2,701) (2,701) Balance as of September 30, 2025 (unaudited) 62,794,305 $ 63 $ 319,511 $ (3,844) $ (306,710) $ 9,020 Accumulated Additional Other Common Stock Paid-In Comprehensive Accumulated Stockholders' Shares Par Value Capital Income Deficit Equity Balance as of June 30, 2024 (unaudited) 54,306,415 $ 54 $ 308,874 $ 2,173 $ (293,674) $ 17,427 Stock-based compensation — — 891 — — 891 Foreign translation adjustment — — — (2,330) — (2,330) ATM activation fees — — (41) — — (41) Issuance of restricted stock units 194,198 — 204 — — 204 Net loss — — — — (2,768) (2,768) Balance at September 30, 2024 (unaudited) 54,500,613 $ 54 $ 309,928 $ (157) $ (296,442) $ 13,383 Balance at December 31, 2023 54,240,265 $ 54 $ 306,187 $ 529 $ (283,290) $ 23,480 Stock-based compensation — — 2,840 — — 2,840 Foreign currency translation adjustment — — — (686) — (686) Issuance of common stock offerings, net of fees 53,290 — 12 — — 12 Warrants issued in connection with long-term debt — — 691 — — 691 Issuance of restricted stock units 207,058 — 198 — — 198 Net loss — — — — (13,152) (13,152) Balance as of September 30, 2024 (unaudited) 54,500,613 $ 54 $ 309,928 $ (157) $ (296,442) $ 13,383 See accompanying notes to condensed consolidated financial statements. CYTOSORBENTS CORPORATION CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) (in thousands) Nine Nine Months Ended Months Ended September 30, September 30, 2025 2024 Cash flows from operating activities Net loss $ (2,701) $ (13,152) Adjustments to reconcile net loss to net cash used in operating activities: Accrued final fee — 111 Amortization of debt discount 571 132 Amortization of loan costs — 58 Depreciation and amortization 1,137 1,181 Amortization of right-of-use asset 109 138 Write-off of patent cost 176 313 Write-off of inventory 253 — Bad debt expense 17 107 Stock-based compensation 1,879 2,840 Foreign currency transaction gains (9,128) (680) Changes in operating assets and liabilities Accounts receivable 560 (629) Inventories (1,247) 153 Prepaid expenses and other current assets 989 505 Other assets — 2 Accounts payable and accrued expenses (167) (3,166) Net cash used in operating activities (7,552) (12,087) Cash flows from investing activities Purchases of property and equipment (56) (215) Payments for patent costs (68) (330) Net cash used in investing activities (124) (545) Cash flows from financing activities Proceeds from long-term debt — 15,000 Repayment of long-term debt — (5,000) Payment of final fee — (150) Payment of loan costs — (698) Equity contributions - net of fees incurred — 12 Proceeds from exercise of common stock warrants 1,439 — Proceeds from rights offering, net of fees incurred 5,392 — Net cash provided by financing activities 6,831 9,164 Effect of exchange rates on cash 139 21 Net change in cash, cash equivalents, and restricted cash (706) (3,447) Cash, cash equivalents, and restricted cash at beginning of year 9,764 15,615 Cash, cash equivalents, and restricted cash – end of period $ 9,058 $ 12,168 Supplemental disclosure of cash flow information Cash paid for interest $ 1,535 $ 772 Supplemental disclosure of non-cash financing activities Warrants issued in connection with long-term debt $ — $ 691 See accompanying notes to condensed consolidated financial statements. Reconciliation of GAAP Financial Measures to Non-GAAP Financial Measures Three Months Ended Nine Months Ended September 30, September 30, 2025 2024 2025 2024 (amounts, in thousands) Net loss $ (3,170) $ (2,768) $ (2,701) $ (13,152) Depreciation and amortization expense $ 364 $ 383 $ 1,137 $ 1,181 Income tax benefit $ (401) $ - $ (401) $ - Interest expense, net $ 645 $ 588 $ 1,866 $ 775 EBITDA – non-GAAP measure $ (2,562) $ (1,797) $ (99) $ (11,196) Non-cash stock-based compensation expense $ 488 $ 891 $ 1,879 $ 2,840 (Gain)/Loss on foreign currency transactions 64 (2,650) (9,128) (680) Adjusted EBITDA – non-GAAP measure $ (2,010) (3,556) $ (7,348) $ (9,036) Net loss $ (3,170) $ (2,768) $ (2,701) $ (13,152) Non-cash stock-based compensation expense 488 891 1,879 2,840 (Gain)/Loss on foreign currency transactions $ 64 $ (2,650) $ (9,128) $ (680) Adjusted net loss – non-GAAP measure $ (2,618) $ (4,527) $ (9,950) $ (10,992) Weighted average common shares outstanding Basic 62,753,959 54,453,006 62,038,902 54,340,583 Diluted 62,753,959 54,453,006 62,038,902 54,340,583 Basic net income (loss) per common share $ (0.05) $ (0.05) $ (0.04) $ (0.24) Diluted net income (loss) per common share $ (0.05) $ (0.05) $ (0.04) $ (0.24) Non-cash stock-based compensation expense - basic $ 0.01 $ 0.02 $ 0.03 $ 0.05 Non-cash stock-based compensation expense - diluted $ 0.01 $ 0.02 $ 0.03 $ 0.05 (Gain)/Loss on foreign currency transactions - basic $ - $ (0.05) $ (0.15) $ (0.01) (Gain)/Loss on foreign currency transactions - diluted $ - $ (0.05) $ (0.15) $ (0.01) Adjusted net income (loss) per common share – basic – non-GAAP measure $ (0.04) $ (0.08) $ (0.16) $ (0.20) Adjusted net income (loss) per common share –diluted – non-GAAP measure $ (0.04) $ (0.08) $ (0.16) $ (0.20) SOURCE Cytosorbents Corp

CytoSorbents Reports Third Quarter 2025 Financial Results and Provides Business Update

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