
iECURE, Inc., a clinical-stage genome editing company developing variant-agnostic in vivo targeted gene insertion therapies for severe inherited neurometabolic disorders, today announced that clinical data from the

<a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fiecure.com%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=iECURE&amp;index=1&amp;md5=ab31b5cfe908fac22941afd7a829cdb7" shape="rect">iECURE</a>, Inc., a clinical-stage genome editing company developing variant-agnostic in vivo targeted gene insertion therapies for severe inherited neurometabolic disorders, today announced that clinical data from the ongoing OTC-HOPE clinical trial evaluating ECUR-506 in neonatal-onset ornithine transcarbamylase (OTC) deficiency will be presented at the American Society of Gene &amp; Cell Therapy (ASGCT) Annual Meeting, taking place May 11-15, 2026 in Boston, and the Society for Inherited Metabolic Disorders (SIMD) Annual Meeting, taking place May 17-20, 2026 in Puerto Rico.


The oral presentation at ASGCT will include preliminary data from study participants in the first three dose cohorts (n=7) of the OTC-HOPE study, including a decreased rate of hyperammonemic crises (HAC) following ECUR-506 administration. HACs represent the most serious and life-threatening manifestation of OTC deficiency, and reductions in these events are considered a clinically meaningful measure of patient benefit in OTC deficiency.


The poster presentation at SIMD will feature one-year post-treatment data from the first infant dosed in the study who achieved a complete clinical response as defined by study protocol, including sustained discontinuation of standard-of-care therapies.


American Society of Gene &amp; Cell Therapy Annual Meeting:


Oral Presentation: Decreased rate of hyperammonemic crises in infants with neonatal-onset OTC deficiency post ECUR-506 administration: preliminary update from the OTC-HOPE study

<ul xmlns="http://www.w3.org/1999/xhtml" class="bwlistdisc">
<li xmlns="http://www.w3.org/1999/xhtml">
Session: Clinical Trials: In vivo gene transfer and gene-editing therapies

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Date/Time: Wednesday, May 13, 4:00 p.m. – 4:15 p.m. ET

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Location: MCEC Room 210ABC (Level 2)

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Presenter: Gabriel Cohn, M.D., MBA, Chief Medical Officer

</li>
</ul>
Society for Inherited Metabolic Disorders Meeting:


Poster Presentation: Sustained Clinical Response in First Clinical Trial Patient Dosed with ECUR-506 One Year Post Discontinuation of Standard of Care (#037)

<ul xmlns="http://www.w3.org/1999/xhtml" class="bwlistdisc">
<li xmlns="http://www.w3.org/1999/xhtml">
Session: Poster Session

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Date/Time: Monday, May 18, 8:00 p.m. – 9:00 p.m. ET

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Location: Rio Mar Ballroom Foyer

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Presenter: George Diaz, M.D., Ph.D., VP, Therapeutic Area Lead, UCDs

</li>
</ul>
iECURE will also be presenting an exhibitor booth at SIMD, May 18-19, 2026, at the Rio Mar Ballroom Foyer in the Wyndham Rio Mar Beach Resort, Booth #6.


About OTC Deficiency


Ornithine transcarbamylase (OTC) deficiency is a rare, serious genetic disorder caused by a defect in a liver enzyme responsible for removing ammonia from the bloodstream. As a result, ammonia, a waste product generated when the body breaks down protein, accumulates in the blood (hyperammonemia), where it is toxic to the brain.


The disease is characterized by recurrent and often unpredictable hyperammonemic crises (HACs), which can lead to hospitalization, irreversible neurological injury, and death. Newborns with neonatal-onset OTC deficiency typically present shortly after birth with symptoms such as lethargy, poor feeding, and vomiting, which can rapidly progress to seizures, coma, and life-threatening complications if not promptly treated.


Current management includes a strict protein-restricted diet and ammonia scavenger medications, which must be taken multiple times daily and often throughout a patient's life. While these approaches may help manage ammonia levels, they do not eliminate the risk of metabolic crises or ongoing disease burden, and patients remain vulnerable to acute decompensation and long-term complications.


About the OTC-HOPE Study


The OTC-HOPE study is a first-in-human clinical trial evaluating ECUR-506 in male infants with genetically confirmed neonatal-onset OTC deficiency. The trial is enrolling eligible male infants up to seven months of age at screening who are diagnosed with severe neonatal-onset OTC deficiency and meet study entry criteria. The primary objective is to assess the safety, tolerability and efficacy of intravenous administration of a single dose of ECUR-506. The study will also assess the pharmacokinetics of ECUR-506 administration and the potential effects of ECUR-506 on clinical outcome measures, disease-specific biologic markers, developmental milestones and quality of life. The main study includes screening, stabilization, dosing eligibility, study drug administration, and six-month follow-up, after which participants transition to a 14.5 year long term follow-up study (ECUR-LTFU). For more information, visit <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fotc-hope.com%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=https%3A%2F%2FOTC-HOPE.com&amp;index=2&amp;md5=2a71503747a69da47178fb81fc4caad2" shape="rect">https://OTC-HOPE.com</a>.


About ECUR-506


ECUR-506 is an investigational in vivo targeted gene insertion therapy designed to restore OTC enzyme activity by inserting a functional copy of the OTC gene into the well-characterized PCSK9 gene locus in liver cells. The therapy utilizes two adeno-associated virus (AAV) vectors using the same capsid, each carrying a distinct payload. One vector contains an ARCUS&#xAE; nuclease designed to create an insertion site within the PCSK9 locus, while the second vector delivers a functional OTC gene for targeted insertion. iECURE has licensed the ARCUS&#xAE; nuclease for ECUR-506 from Precision BioSciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/DTIL">DTIL</a>).1


About iECURE


iECURE is a clinical-stage genome editing company focused on developing therapies that utilize variant-agnostic in vivo targeted gene insertion to address severe genetic diseases with significant unmet need. The company's approach is designed to restore the function of a missing or dysfunctional gene by inserting a functional copy into a patient's genome, enabling durable gene expression and the potential for long-term therapeutic benefit. iECURE is advancing a pipeline of investigational therapies targeting inherited neurometabolic disorders, a group of rare genetic diseases that can lead to severe metabolic and neurological complications, including ornithine transcarbamylase (OTC) deficiency, citrullinemia type 1 (CTLN1), and phenylketonuria (PKU). For more information, visit <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fiecure.com%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=https%3A%2F%2Fiecure.com&amp;index=3&amp;md5=c06e92ea3e25ca8b8bda5952b1291861" shape="rect">https://iecure.com</a> and follow on <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fiecure%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=4&amp;md5=43546d8e56e0b6e2c1000ebddb4b8972" shape="rect">LinkedIn</a>.


About Precision BioSciences &amp; ARCUS&#xAE;


Precision BioSciences, Inc. is a clinical stage gene editing company dedicated to improving life (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/DTIL">DTIL</a>) with its novel and proprietary ARCUS&#xAE; genome editing platform that is designed to differ from other technologies in the way it cuts, its smaller size, and its simpler structure. Key capabilities and differentiating characteristics may enable ARCUS nucleases to drive more intended, defined therapeutic outcomes. Using ARCUS, Precision's pipeline is comprised of in vivo gene editing candidates designed to deliver lasting cures for the broadest range of genetic and infectious diseases, such as chronic hepatitis B where no adequate treatments exist. For more information about Precision BioSciences, visit <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.precisionbiosciences.com%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=www.precisionbiosciences.com&amp;index=5&amp;md5=6d663b1ea3ec12f5ad9c91d0ab8858f3" shape="rect">www.precisionbiosciences.com</a>.


[1] iECURE has licensed the ARCUS&#xAE; nuclease from Precision BioSciences for four gene insertion programs including OTC, CTLN1 and PKU.

<img xmlns="http://www.w3.org/1999/xhtml" alt="" src="https://cts.businesswire.com/ct/CT?id=bwnews&amp;sty=20260428005772r1&amp;sid=benz2&amp;distro=nx&amp;lang=en" style="width:0;height:0"></img>View source version on businesswire.com: <a xmlns="http://www.w3.org/1999/xhtml" href="https://www.businesswire.com/news/home/20260428005772/en/" rel="nofollow">https://www.businesswire.com/news/home/20260428005772/en/</a>
Investors: 
 David Garrett
 <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:dgarrett@iecure.com" shape="rect">dgarrett@iecure.com 
</a> 
 Media: 
 Janine Bogris
 <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:janine.bogris@inizioevoke.com" shape="rect">janine.bogris@inizioevoke.com</a>

DTIL

iECURE to Present Preliminary Clinical Data from Ongoing OTC-HOPE Trial of ECUR-506 in Neonatal-Onset Ornithine Transcarbamylase Deficiency at the ASGCT and SIMD Annual Meetings

iECURE Presents Promising ECUR-506 Data That Could Favorably Impact DTIL

<section class="insight" data-version="1">
 <section data-block="information">
 <h3>Information</h3>
 iECURE, Inc., a clinical-stage genome editing company developing variant-agnostic in vivo targeted gene insertion therapies for severe inherited neurometabolic disorders, today announced that clinical data from the
 </section>

 <section data-block="ai-summary-paragraph">
 <h3>AI Summary</h3>
 iECURE is set to present preliminary findings from the ECUR-506 trial, demonstrating reduced hyperammonemic crises in patients. This development may enhance investor interest in Precision BioSciences (DTIL), as ECUR-506 employs DTIL&#039;s licensed ARCUS® technology, indicating a potential for positive market reactions.
 </section>

 <section data-block="ai-summary-bullets">
 <h3>Key Points</h3>
 <ul><li>iECURE to present ECUR-506 trial data at ASGCT and SIMD in 2026.</li><li>Preliminary results show reduced hyperammonemic crises post-treatment.</li><li>One patient achieved complete response after one year off standard care.</li><li>ECUR-506 uses ARCUS® nuclease technology licensed from Precision BioSciences (DTIL).</li><li>The OTC deficiency treatment addresses severe genetic disorders.</li></ul>
 </section>

 <section data-block="companies-mentioned">
 <h3>Companies Mentioned</h3>
 <ul><li>iECURE (iECURE): iECURE is developing therapies that utilize DTIL&#039;s ARCUS nuclease.</li><li>Precision BioSciences (DTIL): DTIL provides the ARCUS platform crucial for ECUR-506.</li></ul>
 </section>

 <section data-block="category">
 <h3>Corporate Developments</h3>
 This article fits under &#039;Corporate Developments&#039; as it discusses iECURE&#039;s advancements utilizing DTIL&#039;s technology, potentially impacting both companies&#039; future valuations and market positions.
 </section>

 <section data-block="market-moving">
 <h3>Market-Moving</h3>
 <ul><li>Successful trial results could lead to increased licensing revenue for DTIL.</li><li>Positive investor sentiment may arise from clinical efficacy presentations.</li><li>Market attention on DTIL could surge with media coverage during ASGCT and SIMD.</li></ul>
 </section>

 <section data-block="key-facts">
 <h3>Key Facts</h3>
 <ul><li>ECUR-506 is being tested for neonatal-onset OTC deficiency.</li><li>Presentation scheduled at ASGCT on May 13, 2026.</li><li>One-year patient data shows complete response after ECUR-506 treatment.</li><li>DTIL&#039;s ARCUS® technology is pivotal to ECUR-506&#039;s development.</li><li>OTC deficiency can lead to severe neurological complications.</li></ul>
 </section>

 <section data-block="trading-thesis">
 <h3>Trading Thesis</h3>
 Consider buying DTIL ahead of 2026 presentations, which may catalyze price increases.
 </section>
</section>



<a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fiecure.com%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=iECURE&amp;index=1&amp;md5=ab31b5cfe908fac22941afd7a829cdb7" shape="rect">iECURE</a>, Inc., a clinical-stage genome editing company developing variant-agnostic in vivo targeted gene insertion therapies for severe inherited neurometabolic disorders, today announced that clinical data from the ongoing OTC-HOPE clinical trial evaluating ECUR-506 in neonatal-onset ornithine transcarbamylase (OTC) deficiency will be presented at the American Society of Gene &amp; Cell Therapy (ASGCT) Annual Meeting, taking place May 11-15, 2026 in Boston, and the Society for Inherited Metabolic Disorders (SIMD) Annual Meeting, taking place May 17-20, 2026 in Puerto Rico.


The oral presentation at ASGCT will include preliminary data from study participants in the first three dose cohorts (n=7) of the OTC-HOPE study, including a decreased rate of hyperammonemic crises (HAC) following ECUR-506 administration. HACs represent the most serious and life-threatening manifestation of OTC deficiency, and reductions in these events are considered a clinically meaningful measure of patient benefit in OTC deficiency.


The poster presentation at SIMD will feature one-year post-treatment data from the first infant dosed in the study who achieved a complete clinical response as defined by study protocol, including sustained discontinuation of standard-of-care therapies.


American Society of Gene &amp; Cell Therapy Annual Meeting:


Oral Presentation: Decreased rate of hyperammonemic crises in infants with neonatal-onset OTC deficiency post ECUR-506 administration: preliminary update from the OTC-HOPE study

<ul xmlns="http://www.w3.org/1999/xhtml" class="bwlistdisc">
<li xmlns="http://www.w3.org/1999/xhtml">
Session: Clinical Trials: In vivo gene transfer and gene-editing therapies

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Date/Time: Wednesday, May 13, 4:00 p.m. – 4:15 p.m. ET

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Location: MCEC Room 210ABC (Level 2)

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Presenter: Gabriel Cohn, M.D., MBA, Chief Medical Officer

</li>
</ul>
Society for Inherited Metabolic Disorders Meeting:


Poster Presentation: Sustained Clinical Response in First Clinical Trial Patient Dosed with ECUR-506 One Year Post Discontinuation of Standard of Care (#037)

<ul xmlns="http://www.w3.org/1999/xhtml" class="bwlistdisc">
<li xmlns="http://www.w3.org/1999/xhtml">
Session: Poster Session

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Date/Time: Monday, May 18, 8:00 p.m. – 9:00 p.m. ET

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Location: Rio Mar Ballroom Foyer

</li>
<li xmlns="http://www.w3.org/1999/xhtml">
Presenter: George Diaz, M.D., Ph.D., VP, Therapeutic Area Lead, UCDs

</li>
</ul>
iECURE will also be presenting an exhibitor booth at SIMD, May 18-19, 2026, at the Rio Mar Ballroom Foyer in the Wyndham Rio Mar Beach Resort, Booth #6.


About OTC Deficiency


Ornithine transcarbamylase (OTC) deficiency is a rare, serious genetic disorder caused by a defect in a liver enzyme responsible for removing ammonia from the bloodstream. As a result, ammonia, a waste product generated when the body breaks down protein, accumulates in the blood (hyperammonemia), where it is toxic to the brain.


The disease is characterized by recurrent and often unpredictable hyperammonemic crises (HACs), which can lead to hospitalization, irreversible neurological injury, and death. Newborns with neonatal-onset OTC deficiency typically present shortly after birth with symptoms such as lethargy, poor feeding, and vomiting, which can rapidly progress to seizures, coma, and life-threatening complications if not promptly treated.


Current management includes a strict protein-restricted diet and ammonia scavenger medications, which must be taken multiple times daily and often throughout a patient's life. While these approaches may help manage ammonia levels, they do not eliminate the risk of metabolic crises or ongoing disease burden, and patients remain vulnerable to acute decompensation and long-term complications.


About the OTC-HOPE Study


The OTC-HOPE study is a first-in-human clinical trial evaluating ECUR-506 in male infants with genetically confirmed neonatal-onset OTC deficiency. The trial is enrolling eligible male infants up to seven months of age at screening who are diagnosed with severe neonatal-onset OTC deficiency and meet study entry criteria. The primary objective is to assess the safety, tolerability and efficacy of intravenous administration of a single dose of ECUR-506. The study will also assess the pharmacokinetics of ECUR-506 administration and the potential effects of ECUR-506 on clinical outcome measures, disease-specific biologic markers, developmental milestones and quality of life. The main study includes screening, stabilization, dosing eligibility, study drug administration, and six-month follow-up, after which participants transition to a 14.5 year long term follow-up study (ECUR-LTFU). For more information, visit <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fotc-hope.com%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=https%3A%2F%2FOTC-HOPE.com&amp;index=2&amp;md5=2a71503747a69da47178fb81fc4caad2" shape="rect">https://OTC-HOPE.com</a>.


About ECUR-506


ECUR-506 is an investigational in vivo targeted gene insertion therapy designed to restore OTC enzyme activity by inserting a functional copy of the OTC gene into the well-characterized PCSK9 gene locus in liver cells. The therapy utilizes two adeno-associated virus (AAV) vectors using the same capsid, each carrying a distinct payload. One vector contains an ARCUS&#xAE; nuclease designed to create an insertion site within the PCSK9 locus, while the second vector delivers a functional OTC gene for targeted insertion. iECURE has licensed the ARCUS&#xAE; nuclease for ECUR-506 from Precision BioSciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/DTIL">DTIL</a>).1


About iECURE


iECURE is a clinical-stage genome editing company focused on developing therapies that utilize variant-agnostic in vivo targeted gene insertion to address severe genetic diseases with significant unmet need. The company's approach is designed to restore the function of a missing or dysfunctional gene by inserting a functional copy into a patient's genome, enabling durable gene expression and the potential for long-term therapeutic benefit. iECURE is advancing a pipeline of investigational therapies targeting inherited neurometabolic disorders, a group of rare genetic diseases that can lead to severe metabolic and neurological complications, including ornithine transcarbamylase (OTC) deficiency, citrullinemia type 1 (CTLN1), and phenylketonuria (PKU). For more information, visit <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fiecure.com%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=https%3A%2F%2Fiecure.com&amp;index=3&amp;md5=c06e92ea3e25ca8b8bda5952b1291861" shape="rect">https://iecure.com</a> and follow on <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fiecure%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=4&amp;md5=43546d8e56e0b6e2c1000ebddb4b8972" shape="rect">LinkedIn</a>.


About Precision BioSciences &amp; ARCUS&#xAE;


Precision BioSciences, Inc. is a clinical stage gene editing company dedicated to improving life (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/DTIL">DTIL</a>) with its novel and proprietary ARCUS&#xAE; genome editing platform that is designed to differ from other technologies in the way it cuts, its smaller size, and its simpler structure. Key capabilities and differentiating characteristics may enable ARCUS nucleases to drive more intended, defined therapeutic outcomes. Using ARCUS, Precision's pipeline is comprised of in vivo gene editing candidates designed to deliver lasting cures for the broadest range of genetic and infectious diseases, such as chronic hepatitis B where no adequate treatments exist. For more information about Precision BioSciences, visit <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.precisionbiosciences.com%2F&amp;esheet=54523906&amp;newsitemid=20260428005772&amp;lan=en-US&amp;anchor=www.precisionbiosciences.com&amp;index=5&amp;md5=6d663b1ea3ec12f5ad9c91d0ab8858f3" shape="rect">www.precisionbiosciences.com</a>.


[1] iECURE has licensed the ARCUS&#xAE; nuclease from Precision BioSciences for four gene insertion programs including OTC, CTLN1 and PKU.

<img xmlns="http://www.w3.org/1999/xhtml" alt="" src="https://cts.businesswire.com/ct/CT?id=bwnews&amp;sty=20260428005772r1&amp;sid=benz2&amp;distro=nx&amp;lang=en" style="width:0;height:0"></img>View source version on businesswire.com: <a xmlns="http://www.w3.org/1999/xhtml" href="https://www.businesswire.com/news/home/20260428005772/en/" rel="nofollow">https://www.businesswire.com/news/home/20260428005772/en/</a>
Investors: 
 David Garrett
 <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:dgarrett@iecure.com" shape="rect">dgarrett@iecure.com 
</a> 
 Media: 
 Janine Bogris
 <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:janine.bogris@inizioevoke.com" shape="rect">janine.bogris@inizioevoke.com</a>

iECURE is set to present preliminary findings from the ECUR-506 trial, demonstrating reduced hyperammonemic crises in patients. This development may enhance investor interest in Precision BioSciences (DTIL), as ECUR-506 employs DTIL's licensed ARCUS® technology, indicating a potential for positive market reactions.

iecure-to-present-preliminary-clinical-data-from-ongoing-otc-hope-trial-of-ecur-506-in-neonatal-onset-ornithine-transcarbamylase-deficiency-at-the-asgct-and-simd-annual-meetings

iECURE to Present Preliminary Clinical Data from Ongoing OTC-HOPE Trial of ECUR-506 in Neonatal-Onset Ornithine Transcarbamylase Deficiency at the ASGCT and SIMD Annual Meetings

AI Summary

Sentiment Rationale

Trading Thesis

Market-Moving

Key Facts

Companies Mentioned

Corporate Developments

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