Nu-3, a Phase 2-ready candidate targeting the treatment of infected diabetic foot ulcers (iDFU), targets disruption of bacterial membranes through a unique, physical mechanism of action and has demonstrated a high

Nu-3, a Phase 2-ready candidate targeting the treatment of infected diabetic foot ulcers (iDFU), targets disruption of bacterial membranes through a unique, physical mechanism of action and has demonstrated a high barrier to resistance.SARASOTA, Fla., July 22, 2026 /PRNewswire/ -- <a xmlns="http://www.w3.org/1999/xhtml" href="https://edge.prnewswire.com/c/link/?t=0&amp;l=en&amp;o=4736207-1&amp;h=1893292626&amp;u=https%3A%2F%2Flakewoodamedex.com%2F&amp;a=Lakewood-Amedex+Biotherapeutics+Inc." target="_blank" rel="nofollow">Lakewood-Amedex Biotherapeutics Inc.</a>, (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/LABT">LABT</a>, the &#34, Company&#34, )), a clinical-stage biotechnology company advancing a novel class of potent, fast-acting, broad-spectrum antimicrobials for infectious diseases called the Bisphosphocin&#xAE; class, today announced resistance data for Nu-3 in alignment with the Presidential Advisory Council on Combating Antibiotic Resistant Bacteria (PACCARB).
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The 27th Public Meeting of PACCARB convened on June 16, 2026, with discussion focused on the next 5-year iteration of the National Action Plan on Combating Antibiotic-Resistant Bacteria. The plan functions as a roadmap for the U.S. government to combat antimicrobial resistance (AMR) and guides the actions of the federal agencies that interface with AMR.&#34;The rising tide of antimicrobial resistance represents one of the most severe, global crises in modern medicine, making the acceleration of novel therapeutic platforms a foremost priority,&#34; said Kelvin Cooper, Ph.D., CEO of Lakewood-Amedex Biotherapeutics. &#34;We are answering this national call to action by advancing our proprietary Bisphosphocin&#xAE; platform. Our lead candidate, Nu-3, directly aligns with the objectives outlined by PACCARB, by targeting and disrupting bacterial membranes through a unique, physical mechanism of action. Moreover, Nu-3 has demonstrated a high barrier to resistance, positioning it as a highly differentiated candidate with potential to help address these critical national goals, while providing a valuable option for the millions of patients impacted by iDFU.&#34;Lakewood-Amedex Biotherapeutics recently announced that Nu-3 does not induce resistance in a serial passage experiment. In additional laboratory profiling, Nu-3 has demonstrated broad spectrum in vitro activity against bacteria with a diverse range of resistance mechanisms, including modifications to the target of the antibiotic, direct metabolism of the agent, and efflux pump mechanisms. Antibiotic target mutation resistance examples include vanA and vanB variants in E. faecalis and E. faecium, mec variants in H. influenzae, S. aureus, S. pneumoniae, rpoB variants in K. pneumoniae, and PBP2x variants in S. pneumoniae. Antibiotic metabolism resistance examples include the β-lactamase variants NDM, ESBL, AmpC, and CRE, in E. cloacae, E. coli, K. pneumoniae, P. aeruginosa, P. mirabilis, and C. freundii, as well as the metabolic pathway variant sul2 in A. baumannii. Efflux variant examples include metal-tetracycline/H+ antiporter in S. epidermis, and the benzalkonium chloride efflux pump in S. marascens.By bypassing these widespread resistance mechanisms, Lakewood-Amedex Biotherapeutic&#39;s platform offers a promising therapeutic avenue that directly supports the federal mandate to bolster the pipeline of innovative, resistance-evading anti-infective therapies.About Lakewood-Amedex Biotherapeutics Inc. Lakewood-Amedex Biotherapeutics Inc. (NASDAQ: LABT) is a clinical-stage biotechnology Company developing a novel class of fast-acting, broad-spectrum antimicrobials – the Bisphosphocin&#xAE; class - to treat infectious diseases and reduce the threat posed by antibiotic-resistant bacterial strains, including MRSA, VRE, and others. For more information, please visit <a xmlns="http://www.w3.org/1999/xhtml" href="https://edge.prnewswire.com/c/link/?t=0&amp;l=en&amp;o=4736207-1&amp;h=3009597191&amp;u=https%3A%2F%2Flakewoodamedex.com%2F&amp;a=https%3A%2F%2Flakewoodamedex.com" target="_blank" rel="nofollow">https://lakewoodamedex.com</a>.Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding Lakewood-Amedex Biotherapeutics Inc.&#39;s clinical development plans, regulatory strategy, anticipated trial timing, potential regulatory submissions or approvals, and the potential benefits, safety, efficacy and commercial potential of its Bisphosphocin&#xAE; platform and product candidates. These statements are based on current expectations and assumptions and are subject to risks and uncertainties that could cause actual results to differ materially, including risks that clinical trials may not be initiated, completed or successful on expected timelines or at all; preclinical or clinical results may not be predictive of future results; product candidates may not demonstrate safety or efficacy or receive regulatory approval; and risks related to manufacturing, supply, financing and other matters described in the company&#39;s SEC filings, including under &#34;Risk Factors.&#34; Forward-looking statements speak only as of the date of this press release, and the company undertakes no obligation to update them except as required by law.ContactInvestor Relations <a xmlns="http://www.w3.org/1999/xhtml" href="https://edge.prnewswire.com/c/link/?t=0&amp;l=en&amp;o=4736207-1&amp;h=2441581598&amp;u=http%3A%2F%2Fwww.tiberend.com%2F&amp;a=Tiberend+Strategic+Advisors%2C+Inc" target="_blank" rel="nofollow">Tiberend Strategic Advisors, Inc</a>. David Irish (231) 632-0002 <a xmlns="http://www.w3.org/1999/xhtml" href="mailto:dirish@tiberend.com" target="_blank" rel="nofollow">dirish@tiberend.com</a> Media Relations <a xmlns="http://www.w3.org/1999/xhtml" href="https://edge.prnewswire.com/c/link/?t=0&amp;l=en&amp;o=4736207-1&amp;h=2441581598&amp;u=http%3A%2F%2Fwww.tiberend.com%2F&amp;a=Tiberend+Strategic+Advisors%2C+Inc" target="_blank" rel="nofollow">Tiberend Strategic Advisors, Inc</a>. Casey McDonald (646) 577-8520 <a xmlns="http://www.w3.org/1999/xhtml" href="mailto:cmcdonald@tiberend.com" target="_blank" rel="nofollow">cmcdonald@tiberend.com</a> 



<img xmlns="http://www.w3.org/1999/xhtml" title="Cision" width="12" height="12" alt="Cision" src="https://edge.prnewswire.com/c/img/favicon.png?sn=NY09340&amp;sd=2026-07-22"></img> View original content to download multimedia:<a xmlns="http://www.w3.org/1999/xhtml" id="PRNURL" rel="nofollow" href="https://www.prnewswire.com/news-releases/lakewood-amedex-biotherapeutics-highlights-nu-3-resistance-data-in-response-to-national-action-plan-of-presidential-advisory-council-on-combating-antibiotic-resistant-bacteria-302831490.html" target="_blank">https://www.prnewswire.com/news-releases/lakewood-amedex-biotherapeutics-highlights-nu-3-resistance-data-in-response-to-national-action-plan-of-presidential-advisory-council-on-combating-antibiotic-resistant-bacteria-302831490.html</a>SOURCE Lakewood-Amedex Biotherapeutics Inc.

LABT

Lakewood-Amedex Biotherapeutics Highlights Nu-3 Resistance Data in Response to National Action Plan of Presidential Advisory Council on Combating Antibiotic Resistant Bacteria

Lakewood-Amedex presents Nu-3 resistance data aligned with PACCARB goals

<section class="insight" data-version="1">
 <section data-block="information">
 <h3>Information</h3>
 Nu-3, a Phase 2-ready candidate targeting the treatment of infected diabetic foot ulcers (iDFU), targets disruption of bacterial membranes through a unique, physical mechanism of action and has demonstrated a high
 </section>

 <section data-block="ai-summary-paragraph">
 <h3>AI Summary</h3>
 Lakewood-Amedex announced resistance data for Nu-3, a Phase 2-ready antimicrobial for infected diabetic foot ulcers, aligning with PACCARB&#039;s AMR strategy. Nu-3 disrupts bacterial membranes via a physical mechanism and showed broad in vitro activity with no resistance in serial passage. The data reinforce the platform&#039;s differentiation and could influence partnerships, funding, and regulatory discussions for iDFU programs.
 </section>

 <section data-block="ai-summary-bullets">
 <h3>Key Points</h3>
 <ul><li>Nu-3 is Phase 2-ready for infected diabetic foot ulcers. Resistance data align with PACCARB.</li><li>Nu-3 shows broad in vitro activity against bacteria with various resistance mechanisms.</li><li>No resistance observed in serial passage experiments.</li><li>PACCARB public meeting focused on a 5-year AMR plan; Nu-3 aligns with objectives.</li><li>CEO Kelvin Cooper highlights Nu-3&#039;s physical-mechanism differentiation and AMR focus.</li></ul>
 </section>

 <section data-block="companies-mentioned">
 <h3>Companies Mentioned</h3>
 <ul><li>Lakewood-Amedex Biotherapeutics Inc. (LABT): Announced Nu-3 resistance data; frames as aligned with PACCARB; potential for partnerships and funding.</li><li>Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) (PACCARB): U.S. government advisory body shaping AMR policy; favorable context could support LABT&#039;s program.</li></ul>
 </section>

 <section data-block="category">
 <h3>Industry News</h3>
 This is Industry News that centers on policy-aligned AMR development and a Phase 2-ready candidate. It highlights LABT&#039;s narrative within a national action plan, supporting the Bisphosphocin platform&#039;s differentiation and potential strategic partnerships.
 </section>

 <section data-block="market-moving">
 <h3>Market-Moving</h3>
 <ul><li>PACCARB alignment could influence AMR funding and policy favorable to LABT.</li><li>Nu-3 data may spur licensing or partnership discussions.</li><li>Serial-passage results supporting durability may boost credibility.</li><li>Positive press could trigger short-term stock volatility.</li></ul>
 </section>

 <section data-block="key-facts">
 <h3>Key Facts</h3>
 <ul><li>Nu-3 is a Phase 2-ready candidate for infected diabetic foot ulcers (iDFU).</li><li>27th PACCARB Public Meeting held on June 16, 2026.</li><li>PACCARB focuses on the National Action Plan for Combatting AMR (5-year horizon).</li><li>Nu-3 does not induce resistance in serial passage experiments.</li><li>Press release date: July 22, 2026.</li></ul>
 </section>

 <section data-block="trading-thesis">
 <h3>Trading Thesis</h3>
 Near-term upside potential for LABT if data are validated, with a possible re-rating in weeks.
 </section>
</section>


Nu-3, a Phase 2-ready candidate targeting the treatment of infected diabetic foot ulcers (iDFU), targets disruption of bacterial membranes through a unique, physical mechanism of action and has demonstrated a high barrier to resistance.SARASOTA, Fla., July 22, 2026 /PRNewswire/ -- <a xmlns="http://www.w3.org/1999/xhtml" href="https://edge.prnewswire.com/c/link/?t=0&amp;l=en&amp;o=4736207-1&amp;h=1893292626&amp;u=https%3A%2F%2Flakewoodamedex.com%2F&amp;a=Lakewood-Amedex+Biotherapeutics+Inc." target="_blank" rel="nofollow">Lakewood-Amedex Biotherapeutics Inc.</a>, (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/LABT">LABT</a>, the &#34, Company&#34, )), a clinical-stage biotechnology company advancing a novel class of potent, fast-acting, broad-spectrum antimicrobials for infectious diseases called the Bisphosphocin&#xAE; class, today announced resistance data for Nu-3 in alignment with the Presidential Advisory Council on Combating Antibiotic Resistant Bacteria (PACCARB).
 <div xmlns="http://www.w3.org/1999/xhtml" class="PRN_ImbeddedAssetReference" id="DivAssetPlaceHolder1">
 
 <img xmlns="http://www.w3.org/1999/xhtml" src="https://mmx.prnewswire.com/media/MS606836/Lakewood-Amedex-Biotherapeutics-Logo.jpg?id=OA2777876" title="Lakewood-Amedex Biotherapeutics Inc." alt="Lakewood-Amedex Biotherapeutics Inc."></img>
 
 </div>
The 27th Public Meeting of PACCARB convened on June 16, 2026, with discussion focused on the next 5-year iteration of the National Action Plan on Combating Antibiotic-Resistant Bacteria. The plan functions as a roadmap for the U.S. government to combat antimicrobial resistance (AMR) and guides the actions of the federal agencies that interface with AMR.&#34;The rising tide of antimicrobial resistance represents one of the most severe, global crises in modern medicine, making the acceleration of novel therapeutic platforms a foremost priority,&#34; said Kelvin Cooper, Ph.D., CEO of Lakewood-Amedex Biotherapeutics. &#34;We are answering this national call to action by advancing our proprietary Bisphosphocin&#xAE; platform. Our lead candidate, Nu-3, directly aligns with the objectives outlined by PACCARB, by targeting and disrupting bacterial membranes through a unique, physical mechanism of action. Moreover, Nu-3 has demonstrated a high barrier to resistance, positioning it as a highly differentiated candidate with potential to help address these critical national goals, while providing a valuable option for the millions of patients impacted by iDFU.&#34;Lakewood-Amedex Biotherapeutics recently announced that Nu-3 does not induce resistance in a serial passage experiment. In additional laboratory profiling, Nu-3 has demonstrated broad spectrum in vitro activity against bacteria with a diverse range of resistance mechanisms, including modifications to the target of the antibiotic, direct metabolism of the agent, and efflux pump mechanisms. Antibiotic target mutation resistance examples include vanA and vanB variants in E. faecalis and E. faecium, mec variants in H. influenzae, S. aureus, S. pneumoniae, rpoB variants in K. pneumoniae, and PBP2x variants in S. pneumoniae. Antibiotic metabolism resistance examples include the β-lactamase variants NDM, ESBL, AmpC, and CRE, in E. cloacae, E. coli, K. pneumoniae, P. aeruginosa, P. mirabilis, and C. freundii, as well as the metabolic pathway variant sul2 in A. baumannii. Efflux variant examples include metal-tetracycline/H+ antiporter in S. epidermis, and the benzalkonium chloride efflux pump in S. marascens.By bypassing these widespread resistance mechanisms, Lakewood-Amedex Biotherapeutic&#39;s platform offers a promising therapeutic avenue that directly supports the federal mandate to bolster the pipeline of innovative, resistance-evading anti-infective therapies.About Lakewood-Amedex Biotherapeutics Inc. Lakewood-Amedex Biotherapeutics Inc. (NASDAQ: LABT) is a clinical-stage biotechnology Company developing a novel class of fast-acting, broad-spectrum antimicrobials – the Bisphosphocin&#xAE; class - to treat infectious diseases and reduce the threat posed by antibiotic-resistant bacterial strains, including MRSA, VRE, and others. For more information, please visit <a xmlns="http://www.w3.org/1999/xhtml" href="https://edge.prnewswire.com/c/link/?t=0&amp;l=en&amp;o=4736207-1&amp;h=3009597191&amp;u=https%3A%2F%2Flakewoodamedex.com%2F&amp;a=https%3A%2F%2Flakewoodamedex.com" target="_blank" rel="nofollow">https://lakewoodamedex.com</a>.Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding Lakewood-Amedex Biotherapeutics Inc.&#39;s clinical development plans, regulatory strategy, anticipated trial timing, potential regulatory submissions or approvals, and the potential benefits, safety, efficacy and commercial potential of its Bisphosphocin&#xAE; platform and product candidates. These statements are based on current expectations and assumptions and are subject to risks and uncertainties that could cause actual results to differ materially, including risks that clinical trials may not be initiated, completed or successful on expected timelines or at all; preclinical or clinical results may not be predictive of future results; product candidates may not demonstrate safety or efficacy or receive regulatory approval; and risks related to manufacturing, supply, financing and other matters described in the company&#39;s SEC filings, including under &#34;Risk Factors.&#34; Forward-looking statements speak only as of the date of this press release, and the company undertakes no obligation to update them except as required by law.ContactInvestor Relations <a xmlns="http://www.w3.org/1999/xhtml" href="https://edge.prnewswire.com/c/link/?t=0&amp;l=en&amp;o=4736207-1&amp;h=2441581598&amp;u=http%3A%2F%2Fwww.tiberend.com%2F&amp;a=Tiberend+Strategic+Advisors%2C+Inc" target="_blank" rel="nofollow">Tiberend Strategic Advisors, Inc</a>. David Irish (231) 632-0002 <a xmlns="http://www.w3.org/1999/xhtml" href="mailto:dirish@tiberend.com" target="_blank" rel="nofollow">dirish@tiberend.com</a> Media Relations <a xmlns="http://www.w3.org/1999/xhtml" href="https://edge.prnewswire.com/c/link/?t=0&amp;l=en&amp;o=4736207-1&amp;h=2441581598&amp;u=http%3A%2F%2Fwww.tiberend.com%2F&amp;a=Tiberend+Strategic+Advisors%2C+Inc" target="_blank" rel="nofollow">Tiberend Strategic Advisors, Inc</a>. Casey McDonald (646) 577-8520 <a xmlns="http://www.w3.org/1999/xhtml" href="mailto:cmcdonald@tiberend.com" target="_blank" rel="nofollow">cmcdonald@tiberend.com</a> 



<img xmlns="http://www.w3.org/1999/xhtml" title="Cision" width="12" height="12" alt="Cision" src="https://edge.prnewswire.com/c/img/favicon.png?sn=NY09340&amp;sd=2026-07-22"></img> View original content to download multimedia:<a xmlns="http://www.w3.org/1999/xhtml" id="PRNURL" rel="nofollow" href="https://www.prnewswire.com/news-releases/lakewood-amedex-biotherapeutics-highlights-nu-3-resistance-data-in-response-to-national-action-plan-of-presidential-advisory-council-on-combating-antibiotic-resistant-bacteria-302831490.html" target="_blank">https://www.prnewswire.com/news-releases/lakewood-amedex-biotherapeutics-highlights-nu-3-resistance-data-in-response-to-national-action-plan-of-presidential-advisory-council-on-combating-antibiotic-resistant-bacteria-302831490.html</a>SOURCE Lakewood-Amedex Biotherapeutics Inc.

Lakewood-Amedex announced resistance data for Nu-3, a Phase 2-ready antimicrobial for infected diabetic foot ulcers, aligning with PACCARB's AMR strategy. Nu-3 disrupts bacterial membranes via a physical mechanism and showed broad in vitro activity with no resistance in serial passage. The data reinforce the platform's differentiation and could influence partnerships, funding, and regulatory discussions for iDFU programs.

lakewood-amedex-biotherapeutics-highlights-nu-3-resistance-data-in-response-to-national-action-plan-of-presidential-advisory-council-on-combating-antibiotic-resistant-bacteria

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Lakewood-Amedex Biotherapeutics Highlights Nu-3 Resistance Data in Response to National Action Plan of Presidential Advisory Council on Combating Antibiotic Resistant Bacteria

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