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Lexicon Pharmaceuticals Publishes “Relief is Possible: Ensuring Access to Effective Treatments for Chronic Pain”

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-White Paper based on October 2025 Roundtable of diverse stakeholders focused on accelerating innova...

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AI Summary

Lexicon hosted a Roundtable on chronic pain treatments in Washington, D.C. Chronic pain costs the U.S. economy over $720 billion annually. The Relief of Chronic Pain Act proposes Medicare coverage for non-opioid therapies. Lexicon aims to emphasize non-opioid treatments for chronic pain management. A bipartisan effort is needed to tackle chronic pain nationwide.

Sentiment Rationale

The introduction of legislation favorable to non-opioid therapies aligns with Lexicon's strategic focus and can potentially increase market demand and sales for its products. Historical precedence shows that supportive legislation can lead to positive stock performance, such as with opioid-alternative vendors post regulations.

Trading Thesis

While immediate impacts might be muted, passage of the Relief of Chronic Pain Act could lead to substantial long-term growth in demand for Lexicon's non-opioid products, similar to how earlier reforms benefited pharmaceutical companies aligning with new guidelines.

Market-Moving

  • Lexicon hosted a Roundtable on chronic pain treatments in Washington, D.C.
  • Chronic pain costs the U.S. economy over $720 billion annually.
  • The Relief of Chronic Pain Act proposes Medicare coverage for non-opioid therapies.

Key Facts

  • Lexicon hosted a Roundtable on chronic pain treatments in Washington, D.C.
  • Chronic pain costs the U.S. economy over $720 billion annually.
  • The Relief of Chronic Pain Act proposes Medicare coverage for non-opioid therapies.
  • Lexicon aims to emphasize non-opioid treatments for chronic pain management.
  • A bipartisan effort is needed to tackle chronic pain nationwide.

Companies Mentioned

  • PYX (PYX)
  • VMED (VMED)
  • DGX (DGX)

Industry News

The article highlights legislative changes directly affecting non-opioid treatments, aligning with Lexicon's portfolio and mission. With the potential economic burden of chronic pain being so high, positive policy support can significantly enhance sales and market value.

Lexicon Pharmaceuticals Releases White Paper on Chronic Pain Treatment

Publication of “Relief is Possible: Ensuring Access to Effective Treatments for Chronic Pain” emphasizes urgent need for alternatives to opioids.

Overview of the White Paper

On January 9, 2026, Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) announced the release of a White Paper titled “Relief is Possible: Ensuring Access to Effective Treatments for Chronic Pain.” This document is based on the findings from a Roundtable held in October 2025, where diverse stakeholders convened in Washington, D.C. to address the pressing needs of individuals suffering from chronic pain.

The Chronic Pain Crisis

Chronic pain is a debilitating condition that affects approximately one in four American adults, making it one of the leading causes of disability. Each year, chronic pain contributes significantly to direct medical spending, disability claims, and lost productivity. The economic impact is staggering, costing the U.S. over $720 billion annually, including an estimated $190 billion in lost worker productivity.

  • More than 20 million Americans experience high-impact chronic pain.
  • Chronic pain severely disrupts daily activities and can make employment nearly impossible.

Challenges with Current Treatments

Historically, opioids have been the primary treatment option for severe chronic pain. This reliance on opioids has created a complex landscape, with patients and healthcare providers facing difficult choices between effective pain relief and the risks of addiction and overdose.

The recent introduction of the Relief of Chronic Pain Act in the U.S. Senate aims to address these concerns by ensuring Medicare coverage for specific non-opioid medications used to treat chronic pain. This legislation is designed to eliminate barriers that often impede timely access to essential care.

Call to Action from Lexicon Pharmaceuticals

“We are exploring partnerships to prioritize chronic pain on the legislative agenda and support new methods of pain relief,” said Mike Exton, Ph.D., CEO of Lexicon Pharmaceuticals. “The development of non-opioid treatments is critical, not just for patients, but for society as a whole.”

Addressing chronic pain requires a concerted effort from various stakeholders, including patients, caregivers, and clinicians. With more than 60 million Americans living with chronic pain, swift action to enhance access to safe, effective non-opioid therapies is imperative.

Widespread Impact of Chronic Pain

Chronic pain is a condition that does not discriminate; it affects individuals across all demographics and communities. A comprehensive response necessitates bipartisan collaboration that reflects the capabilities of America to innovate and enhance healthcare access.

About Lexicon Pharmaceuticals

Lexicon Pharmaceuticals is dedicated to pioneering transformative medicines aimed at improving patients' lives. Through its Genome5000™ program, Lexicon has identified over 100 protein targets with significant therapeutic potential across various diseases. The company actively develops innovative medicines, with a robust pipeline addressing conditions like heart failure, neuropathic pain, diabetes, and more.

For further information, visit www.lexpharma.com.

For investor and media inquiries, please contact:

Lisa DeFrancesco
Lexicon Pharmaceuticals, Inc.
Email: lexinvest@lexpharma.com

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