Company announces $30 million Series A financing and founding leadership team with expertise in pulmonary drug innovation and track record advancing novel therapies to patients   ORJ-001, set to begin a Phase 2 clinical

DNTH

Oorja Bio Launches as a Clinical-Stage Company to Develop Groundbreaking Therapies for Idiopathic Pulmonary Fibrosis (IPF) and Other Fibrotic Diseases

Oorja Bio Secures $30 Million for Innovative IPF Treatment Development

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    <h3>Information</h3>
    <p>Company announces $30 million Series A financing and founding leadership team with expertise in pulmonary drug innovation and track record advancing novel therapies to patients   ORJ-001, set to begin a Phase 2 clinical</p>
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  <section data-block="ai-summary-paragraph">
    <h3>AI Summary</h3>
    <p>Oorja Bio has raised $30 million in Series A financing to advance ORJ-001, a novel therapeutic targeting idiopathic pulmonary fibrosis (IPF). This funding supports their Phase 2 clinical trial set to start in 2026, potentially offering a disease-modifying treatment in a severely underserved area.</p>
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  <section data-block="ai-summary-bullets">
    <h3>Key Points</h3>
    <ul><li>Oorja Bio raises $30 million in Series A funding.</li><li>ORJ-001 targets idiopathic pulmonary fibrosis, beginning Phase 2 trials in 2026.</li><li>CEO Sujay Kango and team have relevant drug development experience.</li><li>ORJ-001 aims to restore AEC2 function, addressing a key unmet need.</li><li>Current IPF treatments only slow disease, not modify it.</li></ul>
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  <section data-block="companies-mentioned">
    <h3>Companies Mentioned</h3>
    <ul><li><strong>Oorja Bio, Inc. (N/A)</strong>: Developing ORJ-001, targeting idiopathic pulmonary fibrosis and aiming for FDA approval.</li><li><strong>Dianthus Therapeutics (DNTH)</strong>: Sujay Kango, CEO of Oorja Bio, serves on DNTH’s board, enhancing credibility.</li><li><strong>Merck &amp; Co. (MRK)</strong>: Acquired Acceleron Pharma, which developed similar pulmonary therapies.</li></ul>
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  <section data-block="category">
    <h3>Corporate Developments</h3>
    <p>This situation fits within &#039;Corporate Developments&#039; as Oorja Bio&#039;s strategic moves and funding can reshape its competitive landscape. The advancements in pulmonary disease therapeutics also reflect broader industry trends emphasizing innovation in underserved markets.</p>
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    <h3>Market-Moving</h3>
    <ul><li>Oorja Bio&#039;s successful funding may boost investor confidence in similar biotech firms.</li><li>FDA clearance for ORJ-001 could catalyze stock movements related to DNTH.</li><li>Positive Phase 2 trial results could significantly elevate DNTH&#039;s market position.</li><li>New data on ORJ-001&#039;s efficacy may validate DNTH’s strategic focus in pulmonary therapies.</li></ul>
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  <section data-block="key-facts">
    <h3>Key Facts</h3>
    <ul><li>$30 million raised in Series A financing by Oorja Bio.</li><li>Phase 2 clinical trial for ORJ-001 planned for 2026.</li><li>ORJ-001 addresses idiopathic pulmonary fibrosis, a chronic, serious lung disease.</li><li>DNTH&#039;s board member Sujay Kango has expertise from developing sotatercept.</li><li>IPF currently affects over 150,000 adults in the U.S.</li></ul>
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  <section data-block="trading-thesis">
    <h3>Trading Thesis</h3>
    <p>Invest in DNTH as emerging data on ORJ-001 could drive significant stock appreciation in 2026.</p>
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<link type="text/css" rel="stylesheet" href="https://www.globenewswire.com/styles/gnw_nitf.css"></link><p><em>Company announces $30 million Series A financing and founding leadership team with expertise in pulmonary drug innovation and track record advancing novel therapies to patients </em></p>  <p><em>ORJ-001, set to begin a Phase 2 clinical trial in IPF in 2026, is a novel approach to restore the function of alveolar epithelial type 2 (AEC2) cells that are central to the pathogenesis of pulmonary fibrosis</em></p>  <p>HOUSTON, May  19, 2026  (GLOBE NEWSWIRE) -- <a href="https://www.globenewswire.com/Tracker?data=NQixBRqEkbdEf3D64fbxES396G04oCuLbzTJ1SF5BLccucW57kSwA9i814YR_gouODhRmEkHlZG6P6wzLwNW-w==" rel="nofollow" target="_blank">Oorja Bio, Inc.,</a> a clinical-stage biopharmaceutical company developing groundbreaking therapies for fibrotic and cardiopulmonary diseases, today announced the company's launch and $30 million in Series A financing from its founding investor, Westlake BioPartners. The funding will be used to advance the clinical development of ORJ-001, a first-in-class therapeutic to treat idiopathic pulmonary fibrosis (IPF), and build a pipeline of assets to address other diseases involving fibrosis or cardiopulmonary function. Oorja Bio has received IND clearance from the U.S. Food and Drug Administration (FDA) for clinical advancement of ORJ-001 and plans to initiate a Phase 2 clinical trial this year in IPF patients.</p>  <p>Oorja Bio acquired the global rights to ORJ-001 as part of the company's in-licensing strategy for therapeutic innovation in fibrosis. ORJ-001 is the first asset to be acquired by the company to build a portfolio of therapeutics that target the underlying pathophysiology of fibrotic diseases, filling a therapeutic gap for treatments that go beyond symptom management in this challenging disease area. ORJ-001 is a peptide therapeutic for subcutaneous administration designed to treat IPF by restoring the function of alveolar epithelial type 2 (AEC2) cells, promoting alveolar repair and reducing the inflammatory and fibrotic signaling that drives pulmonary fibrosis. In extensive preclinical studies in validated animal models of pulmonary fibrosis, ORJ-001 reversed established fibrosis and regenerated normal lung and alveolar morphology. In additional preclinical studies, ORJ-001 produced positive effects on biomarkers of tissue remodeling associated with fibrotic disease progression.</p>  <p>"Oorja Bio's founding team is very well positioned to accelerate promising drug assets and open up a new chapter for treating IPF and other fibrotic diseases – an area of long-standing challenge for drug development that lacks disease modifying therapies," said Beth Seidenberg, M.D., Founding Managing Director of Westlake BioPartners. "We look forward to continuing to work with the Oorja Bio team as they advance ORJ-001 in the clinic and build a pipeline to bring new therapies that can redefine the standard of care for patients with IPF and fibrotic diseases."</p>  <p>Oorja Bio is led by a founding team of biotechnology leaders, each with a track record of success in strategy, drug development, new treatment paradigms, and company building. Sujay Kango, Chief Executive Officer, and Janethe Pena, MD, PhD, Chief Medical Officer, worked together to lead the product strategy and clinical development of sotatercept at Acceleron Pharma, prior to the company's acquisition by Merck &amp; Co. They were key leaders behind the innovative study designs, clinical implementation and regulatory path for sotatercept, a first-in-class, biologic medicine to treat pulmonary arterial hypertension (PAH), supporting its approval by the U.S. Food and Drug Administration as the first drug in ten years to be approved for the treatment of PAH.</p>  <ul type="disc"><li style="margin-top:6pt;">Sujay Kango, an accomplished biotechnology executive, was most recently the Chief Executive Officer of Tmunity Therapeutics, which was acquired by Gilead. Previously, he was Chief Commercial Officer of Acceleron Pharma, where he was responsible for commercialization and launch of the blockbuster therapy Reblozyl<sup>&#xAE;</sup>, in addition to sotatercept. He currently serves on the board of Dianthus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/DNTH">DNTH</a>).</li><li style="margin-top:6pt;">Dr. Janethe Pena, a clinical development leader, was VP of Pulmonary Medical Research at Acceleron and then continued in a leadership cardiovascular role at Merck to bring sotatercept through the first BLA submission for FDA approval. She was VP of Pulmonary Clinical Development at Bayer where she worked on the pivotal trials leading to approval for Adempas<sup>&#xAE;</sup> for two types of pulmonary hypertension.</li><li style="margin-top:6pt;">Connie Coulomb, Chief Business Officer of Oorja Bio, has 25 years of experience with a strong record of executing multiple strategic transactions and driving commercial successes. Ms. Coulomb has held global commercial leadership and drug product launch roles at Amgen, Biogen, Onyx Pharmaceuticals, and Merck &amp; Co.<br></br></li></ul>  <p>"Our team is energized to deliver on our goal of redefining the future of fibrotic diseases, beginning with ORJ-001," said Mr. Kango. "As we advance ORJ-001 in the clinic, we are embracing the paradigm shift in our biological understanding of IPF pathology that aligns with the central role of the alveolar epithelium. ORJ-001 was designed with this biology in mind and may provide, for the first time, a therapeutic intervention that repairs and reverses fibrosis and promotes disease modification."</p>  <p><strong>About Idiopathic Pulmonary Fibrosis</strong><br></br>Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and life-threatening lung disease affecting more than 150,000 adults in the United States. It is characterized by progressive fibrosis of lung tissue, leading to declining lung function, respiratory failure, and ultimately death. Although the biological triggers of IPF onset remain incompletely understood, impaired epithelial regeneration following lung injury is recognized as a key driver of disease pathogenesis. In particular, the central role of alveolar epithelial type 2 (AEC2) cells in maintaining and repairing the lung epithelium has been well established. IPF remains an area of significant unmet medical need. Currently approved therapies can slow disease progression but do not prevent the continued decline in lung function. As a result, prognosis remains poor, with an average life expectancy of three to five years after diagnosis.</p>  <p><strong>About ORJ-001 and Targeting Alveolar Epithelial Type 2 (AEC2) Cells</strong><br></br>ORJ-001 is a first-in-class peptide therapeutic for subcutaneous administration designed to treat idiopathic pulmonary fibrosis (IPF) by restoring the function of alveolar epithelial type 2 (AEC2) cells, promoting alveolar repair and reducing the inflammatory and fibrotic signaling that drives pulmonary fibrosis. It is an agonist of β1 integrin, a transmembrane protein that plays a critical role in AEC2 function within its cellular niche by transducing biochemical and mechanical signals from the extracellular matrix. β1 integrin activity is essential for regulating AEC2 cell fate, including senescence and differentiation into mature alveolar epithelial type 1 (AEC1) cells, which line the majority of the alveolar surface and are key to epithelial function. It also influences inflammatory signaling pathways implicated in fibrosis. Through these multimodal effects, ORJ-001 has the potential to both halt disease progression and promote repair of the fibrotic damage characteristic of IPF.</p>  <p><strong>About Oorja Bio</strong><br></br><a href="https://www.globenewswire.com/Tracker?data=NQixBRqEkbdEf3D64fbxEVCxxytj2Zpux3CkYXEynxsIkPBH4B_F7u5XKONlwGpjWL33YT6pETAGu2bECj2rwA==" rel="nofollow" target="_blank">Oorja Bio, Inc.</a> is a clinical-stage biotechnology company developing groundbreaking therapies for idiopathic pulmonary fibrosis (IPF) and other fibrotic and cardiopulmonary diseases by targeting mechanisms underlying the pathophysiology of disease. ORJ-001, its lead drug candidate, is designed to restore function of alveolar epithelial type 2 (AEC2) cells to promote cellular repair and remodel fibrotic tissue. Oorja Bio was founded with initial investment from Westlake BioPartners. The company is based in in Houston, TX. For more information about Oorja Bio, visit <a href="https://www.globenewswire.com/Tracker?data=mPmucftoGMOimklpuUPltPpAJjgMeao-sdrCo5oKddByHMsSqxEgjdYZDUyrNvKychGAp-O7jeIa_uX5shGWZocuddPOOMHIvGx-MVNGhEo=" rel="nofollow" target="_blank">www.oorjabio.com</a> and follow us on <a href="https://www.globenewswire.com/Tracker?data=hdK3C7kbe_bdPfAo-s4GfdDrbcaI9uF1spjac_RafWx4lajRp3PYkNWHnOKIi68bavI3m4qP0lXC2-E439Iqlx0WK1zVJWOYTgjXo56L0Yk=" rel="nofollow" target="_blank">LinkedIn</a>.</p> <img alt="" class="__GNW8366DE3E__IMG" src="https://www.globenewswire.com/newsroom/ti?nf=OTcyMzEzMSM3NjEwMzE5IzUwMDE2MjgxNw=="></img> <br></br><img alt="" src="https://ml.globenewswire.com/media/YjI4ZmY3NzEtMzU2NS00Mzg1LWFlNTctYzdlMDA3MmE3MTZhLTUwMDE2MjgxNy0yMDI2LTA1LTE5LWVu/tiny/Oorja-Bio.png" referrerpolicy="no-referrer-when-downgrade"></img><pre>Media Contact
Kathryn Morris
The Yates Network LLC
914-204-6412
kathryn@theyatesnetwork.com</pre><p><a href="https://www.globenewswire.com/NewsRoom/AttachmentNg/13c2e486-08d9-4c2a-96bf-2775b89ac959"><img src="https://ml.globenewswire.com/media/13c2e486-08d9-4c2a-96bf-2775b89ac959/small/oorja-bio-logo-png.png" border="0" width="150" height="46" alt="Primary Logo"></img></a></p>

Oorja Bio has raised $30 million in Series A financing to advance ORJ-001, a novel therapeutic targeting idiopathic pulmonary fibrosis (IPF). This funding supports their Phase 2 clinical trial set to start in 2026, potentially offering a disease-modifying treatment in a severely underserved area.

Oorja Bio Launches as a Clinical-Stage Company to Develop Groundbreaking Therapies for Idiopathic Pulmonary Fibrosis (IPF) and Other Fibrotic Diseases

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