
Silence Therapeutics plc (&#34;Silence&#34; or the &#34;Company&#34;), a global clinical-stage biotechnology company developing novel short interfering RNA (&#34;siRNA&#34;) therapies, today announced that it has

<p xmlns="http://www.w3.org/1999/xhtml">
Silence Therapeutics plc ("Silence" or the "Company"), a global clinical-stage biotechnology company developing novel short interfering RNA ("siRNA") therapies, today announced that it has commenced an underwritten public offering of approximately $150 million of its American Depositary Shares ("ADSs"), each representing three ordinary shares of £0.05 each in the capital of the Company, in the United States. The proposed offering is a public offering registered under the U.S. Securities Act of 1933, as amended. In addition, Silence intends to grant the underwriters a 30-day option to purchase up to an additional 15% of the total number of ADSs proposed to be sold in the proposed offering at the public offering price, less the underwriting discounts and commissions. All of the ADSs are being offered by Silence. The proposed offering is subject to market and other conditions.

</p><p xmlns="http://www.w3.org/1999/xhtml">
Jefferies, Morgan Stanley, Cantor and William Blair are acting as joint book-running managers for the proposed offering.

</p><p xmlns="http://www.w3.org/1999/xhtml">
The proposed offering is being made pursuant to a registration statement on Form S-3, including a base prospectus, that was previously filed with the U.S. Securities and Exchange Commission ("SEC") on May 18, 2026, and declared effective on May 27, 2026. The proposed offering is being made only by means of a prospectus supplement and the accompanying prospectus that will form a part of the registration statement. A preliminary prospectus supplement and the accompanying prospectus relating to the proposed offering will be filed with the SEC and will be available on the SEC’s website at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.sec.gov&amp;esheet=54587042&amp;newsitemid=20260810617219&amp;lan=en-US&amp;anchor=www.sec.gov&amp;index=1&amp;md5=bf6707dae0d7e5c3fb12aa65a7be0352" shape="rect">www.sec.gov</a>. Copies of the preliminary prospectus supplement and the accompanying prospectus, when available, may be obtained from: Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, New York 10022, or by email at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:Prospectus_Department@jefferies.com" shape="rect">Prospectus_Department@jefferies.com</a>; Morgan Stanley &amp; Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, NY 10014, or by email at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:prospectus@morganstanley.com" shape="rect">prospectus@morganstanley.com</a>; Cantor Fitzgerald &amp; Co., Attention: Capital Markets, 110 East 59th Street, 6th Floor, New York, NY 10022, or by email at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:prospectus@cantor.com" shape="rect">prospectus@cantor.com</a>; or William Blair &amp; Company, L.L.C., Attention: Prospectus Department, 150 North Riverside Plaza, Chicago, IL 60606, by telephone at (800) 621-0687, or by email at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:prospectus@williamblair.com" shape="rect">prospectus@williamblair.com</a>.

</p><p xmlns="http://www.w3.org/1999/xhtml">
This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor will there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation, or sale would be unlawful before registration or qualification under the securities laws of any such state or jurisdiction.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">For readers in the European Economic Area ("EEA")</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
In any EEA member state (each, a "<b xmlns="http://www.w3.org/1999/xhtml">Relevant State</b>"), this press release and any offering are only addressed to and directed at persons who are qualified investors (&#34;<b xmlns="http://www.w3.org/1999/xhtml">Qualified Investors</b>&#34;) in that Relevant State within the meaning of the Prospectus Regulation. The term "Prospectus Regulation" means Regulation (EU) 2017/1129.

</p><p xmlns="http://www.w3.org/1999/xhtml">
This press release must not be acted on or relied on in any EEA member state by persons who are not Qualified Investors. Any investment or investment activity to which this press release relates is available only to and will only be engaged with Qualified Investors in any EEA member state.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">For readers in the United Kingdom</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
In the UK, this press release and any offering are only addressed to and directed at persons who are qualified investors (&#34;<b xmlns="http://www.w3.org/1999/xhtml">UK Qualified Investors</b>&#34;) within the meaning of paragraph 15 of Part 2 of Schedule 1 of The Public Offers and Admissions to Trading Regulations 2024/105.

</p><p xmlns="http://www.w3.org/1999/xhtml">
In the United Kingdom, this press release, in so far as it constitutes an invitation or inducement to enter into investment activity within the meaning of section 21 of the Financial Services and Markets Act 2000, as amended (the "<b xmlns="http://www.w3.org/1999/xhtml">FSMA</b>"), and any offering are only addressed to and directed at UK Qualified Investors (i) who have professional experience in matters relating to investments falling within Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005, as amended, or the "Order", and/or (ii) who are high net worth companies (or persons to whom it may otherwise be lawfully communicated) falling within Article 49(2)(a) to (d) of the Order (all such persons together being referred to as "<b xmlns="http://www.w3.org/1999/xhtml">relevant persons</b>").

</p><p xmlns="http://www.w3.org/1999/xhtml">
This press release must not be acted on or relied on in the United Kingdom by persons who are not relevant persons. Any investment or investment activity to which this press release relates is available only to and will only be engaged with relevant persons in the United Kingdom. This press release does not contain an offer or constitute any part of an offer to the public within the meaning of sections 85 and 102B of the FSMA or otherwise.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">About Silence Therapeutics</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Silence Therapeutics is a global clinical-stage biotechnology company committed to transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. Silence leverages its mRNAi GOLD&#x2122; platform to create innovative siRNA therapies designed to precisely target and silence genes that cause disease. The Company is advancing a growing pipeline of siRNA product candidates targeting areas of high unmet need across rare and common diseases where treatments are limited or inadequate.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Forward-Looking Statements</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
This press release contains "forward-looking statements" within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. All statements in this press release other than statements of historical facts are "forward-looking statements." These statements may be identified by words such as "aims," "anticipates," "believes," "could," "estimates," "expects," "forecasts," "goal," "intends," "may," "plans," "possible," "potential," "seeks," "will" and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements concerning the anticipated public offering, expected proceeds from the proposed offering, and expected closing of the proposed offering. Factors that could cause actual results to differ include, but are not limited to, risks and uncertainties related to the market conditions and the completion of the proposed public offering on the anticipated terms or at all. Other factors that may cause the Company’s actual results to differ from those expressed or implied in the forward-looking statements in this press release are identified under the heading "Risk Factors" in the Company’s Annual Report on Form 10-K, filed with the SEC on March 5, 2026, and in other filings that the Company makes and will make with the SEC in the future. The Company expressly disclaims any obligation to update any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.

</p><p xmlns="http://www.w3.org/1999/xhtml"><img xmlns="http://www.w3.org/1999/xhtml" alt="" src="https://cts.businesswire.com/ct/CT?id=bwnews&amp;sty=20260810617219r1&amp;sid=benz2&amp;distro=nx&amp;lang=en" style="width:0;height:0"></img><span xmlns="http://www.w3.org/1999/xhtml" class="bwct31415"></span></p><p xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink"><span xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink-phrase">View source version on businesswire.com: </span><span xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink-link"><a xmlns="http://www.w3.org/1999/xhtml" href="https://www.businesswire.com/news/home/20260810617219/en/" rel="nofollow">https://www.businesswire.com/news/home/20260810617219/en/</a></span></p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Inquiries: 
</b><br xmlns="http://www.w3.org/1999/xhtml"></br><b xmlns="http://www.w3.org/1999/xhtml">Silence Therapeutics plc 
</b><br xmlns="http://www.w3.org/1999/xhtml"></br>Gem Hopkins, VP, Head of IR and Corporate Communications
<br xmlns="http://www.w3.org/1999/xhtml"></br>+1 (646) 637-3208
<br xmlns="http://www.w3.org/1999/xhtml"></br><a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:ir@silence-therapeutics.com" shape="rect">ir@silence-therapeutics.com</a>

</p>

Silence Therapeutics Announces Proposed Public Offering of $150 Million of American Depositary Shares

Silence Therapeutics launches $150M ADS offering with 15% greenshoe

<section class="insight" data-version="1">
  <section data-block="information">
    <h3>Information</h3>
    <p>Silence Therapeutics plc (&amp;#34;Silence&amp;#34; or the &amp;#34;Company&amp;#34;), a global clinical-stage biotechnology company developing novel short interfering RNA (&amp;#34;siRNA&amp;#34;) therapies, today announced that it has</p>
  </section>

  <section data-block="ai-summary-paragraph">
    <h3>AI Summary</h3>
    <p>Silence Therapeutics announced an underwritten US public offering of approximately $150 million of ADSs, with a 30-day option to purchase up to 15% more. The deal is being managed by Jefferies, Morgan Stanley, Cantor Fitzgerald and William Blair, with Form S-3 registration effective May 27, 2026. The offering funds the clinical pipeline but could dilute existing shareholders in the near term.</p>
  </section>

  <section data-block="ai-summary-bullets">
    <h3>Key Points</h3>
    <ul><li>Silence launches about $150M US ADS offering. Underwriters may exercise 30-day 15% over-allotment.</li><li>Registration on Form S-3; effective May 27, 2026. Market conditions pending closing.</li><li>Underwriters: Jefferies, Morgan Stanley, Cantor Fitzgerald, William Blair. Proceeds depend on demand.</li><li>Dilution risk may pressure SLN near-term shares; funding could extend runway for pipeline programs.</li></ul>
  </section>

  <section data-block="companies-mentioned">
    <h3>Companies Mentioned</h3>
    <ul><li><strong>Silence Therapeutics plc (SLN)</strong>: Announced an underwritten public offering of ADSs; dilution risk to existing holders.</li><li><strong>Morgan Stanley (MS)</strong>: Joint book-running manager; underwriting involvement supports execution but does not negate dilution.</li><li><strong>Jefferies Financial Group (JEF)</strong>: Joint book-running manager; participant in underwriting syndicate; potential fees.</li><li><strong>Cantor Fitzgerald</strong>: Joint book-running manager; private firm, part of underwriting syndicate.</li><li><strong>William Blair</strong>: Joint book-running manager; private firm, part of underwriting syndicate.</li></ul>
  </section>

  <section data-block="category">
    <h3>Corporate Developments</h3>
    <p>Category: Corporate Developments. The article documents a financing transaction that affects liquidity and potential equity dilution, a key driver of near-term stock dynamics for SLN while enhancing funding runway for its siRNA pipeline.</p>
  </section>

  <section data-block="market-moving">
    <h3>Market-Moving</h3>
    <ul><li>Offering size and 15% greenshoe imply meaningful dilution risk.</li><li>Closing timing depends on market conditions, influencing near-term price action.</li><li>Syndicate credibility from MS/JEF may cushion, but dilution remains likely.</li></ul>
  </section>

  <section data-block="key-facts">
    <h3>Key Facts</h3>
    <ul><li>Offering size: approximately $150 million of Silence ADSs.</li><li>ADSs represent three ordinary shares each.</li><li>30-day option to purchase up to 15% more ADSs.</li><li>Registration on Form S-3; effective May 27, 2026.</li><li>Underwriters: Jefferies, Morgan Stanley, Cantor Fitzgerald, William Blair.</li></ul>
  </section>

  <section data-block="trading-thesis">
    <h3>Trading Thesis</h3>
    <p>Bearish near-term: dilution pressure likely within 1–3 months.</p>
  </section>
</section>


<p xmlns="http://www.w3.org/1999/xhtml">
Silence Therapeutics plc ("Silence" or the "Company"), a global clinical-stage biotechnology company developing novel short interfering RNA ("siRNA") therapies, today announced that it has commenced an underwritten public offering of approximately $150 million of its American Depositary Shares ("ADSs"), each representing three ordinary shares of £0.05 each in the capital of the Company, in the United States. The proposed offering is a public offering registered under the U.S. Securities Act of 1933, as amended. In addition, Silence intends to grant the underwriters a 30-day option to purchase up to an additional 15% of the total number of ADSs proposed to be sold in the proposed offering at the public offering price, less the underwriting discounts and commissions. All of the ADSs are being offered by Silence. The proposed offering is subject to market and other conditions.

</p><p xmlns="http://www.w3.org/1999/xhtml">
Jefferies, Morgan Stanley, Cantor and William Blair are acting as joint book-running managers for the proposed offering.

</p><p xmlns="http://www.w3.org/1999/xhtml">
The proposed offering is being made pursuant to a registration statement on Form S-3, including a base prospectus, that was previously filed with the U.S. Securities and Exchange Commission ("SEC") on May 18, 2026, and declared effective on May 27, 2026. The proposed offering is being made only by means of a prospectus supplement and the accompanying prospectus that will form a part of the registration statement. A preliminary prospectus supplement and the accompanying prospectus relating to the proposed offering will be filed with the SEC and will be available on the SEC’s website at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.sec.gov&amp;esheet=54587042&amp;newsitemid=20260810617219&amp;lan=en-US&amp;anchor=www.sec.gov&amp;index=1&amp;md5=bf6707dae0d7e5c3fb12aa65a7be0352" shape="rect">www.sec.gov</a>. Copies of the preliminary prospectus supplement and the accompanying prospectus, when available, may be obtained from: Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, New York 10022, or by email at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:Prospectus_Department@jefferies.com" shape="rect">Prospectus_Department@jefferies.com</a>; Morgan Stanley &amp; Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, NY 10014, or by email at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:prospectus@morganstanley.com" shape="rect">prospectus@morganstanley.com</a>; Cantor Fitzgerald &amp; Co., Attention: Capital Markets, 110 East 59th Street, 6th Floor, New York, NY 10022, or by email at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:prospectus@cantor.com" shape="rect">prospectus@cantor.com</a>; or William Blair &amp; Company, L.L.C., Attention: Prospectus Department, 150 North Riverside Plaza, Chicago, IL 60606, by telephone at (800) 621-0687, or by email at <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:prospectus@williamblair.com" shape="rect">prospectus@williamblair.com</a>.

</p><p xmlns="http://www.w3.org/1999/xhtml">
This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor will there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation, or sale would be unlawful before registration or qualification under the securities laws of any such state or jurisdiction.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">For readers in the European Economic Area ("EEA")</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
In any EEA member state (each, a "<b xmlns="http://www.w3.org/1999/xhtml">Relevant State</b>"), this press release and any offering are only addressed to and directed at persons who are qualified investors (&#34;<b xmlns="http://www.w3.org/1999/xhtml">Qualified Investors</b>&#34;) in that Relevant State within the meaning of the Prospectus Regulation. The term "Prospectus Regulation" means Regulation (EU) 2017/1129.

</p><p xmlns="http://www.w3.org/1999/xhtml">
This press release must not be acted on or relied on in any EEA member state by persons who are not Qualified Investors. Any investment or investment activity to which this press release relates is available only to and will only be engaged with Qualified Investors in any EEA member state.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">For readers in the United Kingdom</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
In the UK, this press release and any offering are only addressed to and directed at persons who are qualified investors (&#34;<b xmlns="http://www.w3.org/1999/xhtml">UK Qualified Investors</b>&#34;) within the meaning of paragraph 15 of Part 2 of Schedule 1 of The Public Offers and Admissions to Trading Regulations 2024/105.

</p><p xmlns="http://www.w3.org/1999/xhtml">
In the United Kingdom, this press release, in so far as it constitutes an invitation or inducement to enter into investment activity within the meaning of section 21 of the Financial Services and Markets Act 2000, as amended (the "<b xmlns="http://www.w3.org/1999/xhtml">FSMA</b>"), and any offering are only addressed to and directed at UK Qualified Investors (i) who have professional experience in matters relating to investments falling within Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005, as amended, or the "Order", and/or (ii) who are high net worth companies (or persons to whom it may otherwise be lawfully communicated) falling within Article 49(2)(a) to (d) of the Order (all such persons together being referred to as "<b xmlns="http://www.w3.org/1999/xhtml">relevant persons</b>").

</p><p xmlns="http://www.w3.org/1999/xhtml">
This press release must not be acted on or relied on in the United Kingdom by persons who are not relevant persons. Any investment or investment activity to which this press release relates is available only to and will only be engaged with relevant persons in the United Kingdom. This press release does not contain an offer or constitute any part of an offer to the public within the meaning of sections 85 and 102B of the FSMA or otherwise.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">About Silence Therapeutics</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Silence Therapeutics is a global clinical-stage biotechnology company committed to transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. Silence leverages its mRNAi GOLD&#x2122; platform to create innovative siRNA therapies designed to precisely target and silence genes that cause disease. The Company is advancing a growing pipeline of siRNA product candidates targeting areas of high unmet need across rare and common diseases where treatments are limited or inadequate.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Forward-Looking Statements</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
This press release contains "forward-looking statements" within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. All statements in this press release other than statements of historical facts are "forward-looking statements." These statements may be identified by words such as "aims," "anticipates," "believes," "could," "estimates," "expects," "forecasts," "goal," "intends," "may," "plans," "possible," "potential," "seeks," "will" and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements concerning the anticipated public offering, expected proceeds from the proposed offering, and expected closing of the proposed offering. Factors that could cause actual results to differ include, but are not limited to, risks and uncertainties related to the market conditions and the completion of the proposed public offering on the anticipated terms or at all. Other factors that may cause the Company’s actual results to differ from those expressed or implied in the forward-looking statements in this press release are identified under the heading "Risk Factors" in the Company’s Annual Report on Form 10-K, filed with the SEC on March 5, 2026, and in other filings that the Company makes and will make with the SEC in the future. The Company expressly disclaims any obligation to update any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.

</p><p xmlns="http://www.w3.org/1999/xhtml"><img xmlns="http://www.w3.org/1999/xhtml" alt="" src="https://cts.businesswire.com/ct/CT?id=bwnews&amp;sty=20260810617219r1&amp;sid=benz2&amp;distro=nx&amp;lang=en" style="width:0;height:0"></img><span xmlns="http://www.w3.org/1999/xhtml" class="bwct31415"></span></p><p xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink"><span xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink-phrase">View source version on businesswire.com: </span><span xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink-link"><a xmlns="http://www.w3.org/1999/xhtml" href="https://www.businesswire.com/news/home/20260810617219/en/" rel="nofollow">https://www.businesswire.com/news/home/20260810617219/en/</a></span></p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Inquiries: 
</b><br xmlns="http://www.w3.org/1999/xhtml"></br><b xmlns="http://www.w3.org/1999/xhtml">Silence Therapeutics plc 
</b><br xmlns="http://www.w3.org/1999/xhtml"></br>Gem Hopkins, VP, Head of IR and Corporate Communications
<br xmlns="http://www.w3.org/1999/xhtml"></br>+1 (646) 637-3208
<br xmlns="http://www.w3.org/1999/xhtml"></br><a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:ir@silence-therapeutics.com" shape="rect">ir@silence-therapeutics.com</a>

</p>

Silence Therapeutics announced an underwritten US public offering of approximately $150 million of ADSs, with a 30-day option to purchase up to 15% more. The deal is being managed by Jefferies, Morgan Stanley, Cantor Fitzgerald and William Blair, with Form S-3 registration effective May 27, 2026. The offering funds the clinical pipeline but could dilute existing shareholders in the near term.

News insight

Silence Therapeutics Announces Proposed Public Offering of $150 Million of American Depositary Shares

AI summary

Sentiment rationale

Key facts

Corporate Developments