
Combines validated scientific engines with accelerated computing and AI to enable more scalable, integrated modeling workflows across the drug development lifecycle


Simulations Plus, Inc. (NASDAQ:SLP) (&#34;Simulations

<p xmlns="http://www.w3.org/1999/xhtml" class="bwalignc">
<i xmlns="http://www.w3.org/1999/xhtml">Combines validated scientific engines with accelerated computing and AI to enable more scalable, integrated modeling workflows across the drug development lifecycle</i>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/SLP">SLP</a>) ("Simulations Plus" or the "Company"), a global leader in model-informed and AI-accelerated drug development that advances biopharma innovation, today announced the launch of a technical collaboration with NVIDIA focused on enabling GPU-accelerated simulation and AI-assisted workflows for computationally intensive modeling applications within the drug development lifecycle.

</p><p xmlns="http://www.w3.org/1999/xhtml">
The collaboration brings together Simulations Plus' validated scientific engines across physiologically-based pharmacokinetics (PBPK), pharmacokinetics/pharmacodynamics (PK/PD), and quantitative systems pharmacology (QSP) with NVIDIA AI infrastructure to accelerate and scale simulation cycles, parameter exploration, and virtual population studies. Together, these capabilities address two core constraints in model-informed drug development (MIDD): reducing manual, expertise-driven work and enabling large-scale exploration of model structures and parameters in parallel—shifting modeling from a sequential process to a more iterative, data-informed workflow operating at program-relevant timelines.

</p><p xmlns="http://www.w3.org/1999/xhtml">
NVIDIA contributes advanced computing infrastructure and expertise in accelerated inference and GPU-native optimization to improve simulation performance and enable interactive, AI-assisted workflows. NVIDIA also brings access to its life sciences ecosystem, including the <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.nvidia.com%2Fen-us%2Findustries%2Fhealthcare-life-sciences%2F&amp;esheet=54529559&amp;newsitemid=20260506350085&amp;lan=en-US&amp;anchor=NVIDIA&amp;index=1&amp;md5=97d484cfcc7e97008837ed79f5a0fe36" shape="rect">NVIDIA </a><a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.nvidia.com%2Fen-us%2Findustries%2Fhealthcare-life-sciences%2F&amp;esheet=54529559&amp;newsitemid=20260506350085&amp;lan=en-US&amp;anchor=BioNeMo+platform&amp;index=2&amp;md5=470974ed5dc59b09cce8058079f38074" shape="rect">BioNeMo platform</a> and a global network of pharmaceutical partners, supporting broader engagement and adoption.

</p><p xmlns="http://www.w3.org/1999/xhtml">
"For three decades, Simulations Plus has helped pharmaceutical and biotechnology organizations apply modeling and simulation with confidence across drug development. Our collaboration with NVIDIA brings together validated science, accelerated computing, and AI capabilities in a way that expands what scientific teams are able to explore and accomplish," said Shawn O'Connor, Chief Executive Officer of Simulations Plus.

</p><p xmlns="http://www.w3.org/1999/xhtml">
The collaboration is initially focused on three areas:

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Next-generation scientific engines</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus has begun developing GPU-optimized simulation capabilities for QSP and PK/PD applications, reducing runtimes and enabling broader exploration of complex biological systems. This enables scientists to evaluate a broader range of hypotheses without pre-pruning models, increasing confidence in model selection and supporting more robust program decisions.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">AI-assisted scientific workflows</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus is applying AI-assisted approaches, informed by NVIDIA's expertise in accelerated inference and agentic AI, to support model construction, parameter fitting, diagnostics, and refinement—reducing manual effort and accelerating iteration from question to analysis. By reducing manual, time-intensive steps, these workflows will allow scientists to focus more on scientific interpretation and decision-making, significantly accelerating iteration cycles within drug development programs.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Advancing quantitative systems pharmacology</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus is prioritizing QSP workflows—one of the most computationally demanding areas in drug development—by applying GPU acceleration and AI-assisted methods to improve simulation efficiency and expand practical use in pharmaceutical R&amp;D. Current testing shows up to a 75% reduction in time required for end-to-end QSP modeling, enabling faster iteration and expanding the practical use of QSP within program timelines.

</p><p xmlns="http://www.w3.org/1999/xhtml">
As part of the collaboration, the companies plan to engage select pharmaceutical partners to evaluate these capabilities in real-world drug development workflows, with initial focus on high-complexity modeling use cases.

</p><p xmlns="http://www.w3.org/1999/xhtml">
"Scientific teams are asking for faster iteration, greater scale, and better ways to work across increasingly complex modeling problems. By combining our validated scientific engines with AI-assisted workflows and accelerated computing, we are extending our platform into a more integrated modeling ecosystem—where workflows scale across domains like QSP while remaining grounded in reproducible, scientifically validated outputs," said Erik Guffrey, Co-Chief Product and Technology Officer of Simulations Plus.

</p><p xmlns="http://www.w3.org/1999/xhtml">
"Biopharma teams need platforms that can connect mechanistic modeling, AI, and high-performance simulation into workflows scientists can actually use. By bringing NVIDIA accelerated computing and AI infrastructure together with Simulations Plus' deep expertise in model-informed drug development, we can help researchers run more complex models, explore larger design spaces, and move from insight to decision faster,&#34; said Anthony Costa, Director of Digital Biology and Health, NVIDIA.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">About Simulations Plus, Inc.</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus is a global leader in model-informed and AI-accelerated drug development. We create value for our clients by accelerating the discovery, development, and commercialization of pharmaceuticals and other products through innovative science-based software and consulting solutions. For more information, visit <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.simulations-plus.com&amp;esheet=54529559&amp;newsitemid=20260506350085&amp;lan=en-US&amp;anchor=www.simulations-plus.com&amp;index=3&amp;md5=529b4be1d4e7c5b7ef52a9cf75defa60" shape="rect">www.simulations-plus.com</a>.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Forward-Looking Statements</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Except for historical information, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties. Words like "believe," "will," "can," "expect," "anticipate" and similar expressions (or the negative of such terms, as well as other words or expressions referencing future events, conditions or circumstances) mean that these are our best estimates as of this writing, but there can be no assurances that expected or anticipated results or events will actually take place, so our actual future results could differ significantly from those statements. Factors that could cause or contribute to such differences include, but are not limited to: effectiveness of our new operational structure, our ability to maintain our competitive advantages, acceptance of new software and improved versions of our existing software by our customers, the general economics of the pharmaceutical industry, our ability to finance growth, our ability to continue to attract and retain highly qualified technical staff, market conditions, macroeconomic factors, and a sustainable market. Further information on our risk factors is contained in our quarterly, annual and current reports and filed with the U.S. Securities and Exchange Commission.

</p><p xmlns="http://www.w3.org/1999/xhtml"><img xmlns="http://www.w3.org/1999/xhtml" alt="" src="https://cts.businesswire.com/ct/CT?id=bwnews&amp;sty=20260506350085r1&amp;sid=benz2&amp;distro=nx&amp;lang=en" style="width:0;height:0"></img><span xmlns="http://www.w3.org/1999/xhtml" class="bwct31415"></span></p><p xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink"><span xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink-phrase">View source version on businesswire.com: </span><span xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink-link"><a xmlns="http://www.w3.org/1999/xhtml" href="https://www.businesswire.com/news/home/20260506350085/en/" rel="nofollow">https://www.businesswire.com/news/home/20260506350085/en/</a></span></p><p xmlns="http://www.w3.org/1999/xhtml">
Financial Profiles
<br xmlns="http://www.w3.org/1999/xhtml"></br>Lisa Fortuna
<br xmlns="http://www.w3.org/1999/xhtml"></br>310-622-8251
<br xmlns="http://www.w3.org/1999/xhtml"></br><a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:slp@finprofiles.com" shape="rect">slp@finprofiles.com</a>

</p>

Simulations Plus and NVIDIA Collaborate to Scale GPU-Accelerated, AI-Assisted Modeling Workflows

Simulations Plus Partners with NVIDIA to Accelerate Drug Development Workflows

<section class="insight" data-version="1">
  <section data-block="information">
    <h3>Information</h3>
    <p>Combines validated scientific engines with accelerated computing and AI to enable more scalable, integrated modeling workflows across the drug development lifecycle


Simulations Plus, Inc. (NASDAQ:SLP) (&amp;#34;Simulations</p>
  </section>

  <section data-block="ai-summary-paragraph">
    <h3>AI Summary</h3>
    <p>Simulations Plus has entered a collaboration with NVIDIA to enhance drug development through AI and GPU-accelerated simulations, significantly reducing modeling time. This may lead to improved decision-making and increased adoptions of Simulations Plus&#039; solutions within the pharmaceutical industry.</p>
  </section>

  <section data-block="ai-summary-bullets">
    <h3>Key Points</h3>
    <ul><li>Simulations Plus and NVIDIA announce a technical collaboration.</li><li>Collaboration focuses on AI and GPU-accelerated workflows for drug development.</li><li>Projected 75% reduction in time for quantitative systems pharmacology modeling.</li><li>New workflows aim to enhance data-informed decision-making in drug development.</li><li>Partnership to engage pharmaceutical firms for real-world application evaluation.</li></ul>
  </section>

  <section data-block="companies-mentioned">
    <h3>Companies Mentioned</h3>
    <ul><li><strong>NVIDIA (NVDA)</strong>: NVIDIA&#039;s technology boosts SLP&#039;s modeling capabilities, enhancing its market offering.</li></ul>
  </section>

  <section data-block="category">
    <h3>Corporate Developments</h3>
    <p>This news falls under &#039;Corporate Developments&#039; as it marks a significant partnership that could reshape Simulations Plus&#039; operational capabilities and market positioning.</p>
  </section>

  <section data-block="market-moving">
    <h3>Market-Moving</h3>
    <ul><li>Partnership with NVIDIA enhances SLP&#039;s competitive positioning in drug development.</li><li>Reduction in modeling times may lead to broader market adoption of SLP&#039;s products.</li><li>Increased efficiency could drive higher revenues from biopharma clients.</li><li>Success in real-world application testing could significantly boost SLP&#039;s future contracts.</li></ul>
  </section>

  <section data-block="key-facts">
    <h3>Key Facts</h3>
    <ul><li>SLP collaborates with NVIDIA for AI-accelerated drug modeling workflows.</li><li>New GPU capabilities may reduce quantitate systems pharmacology modeling time by up to 75%.</li><li>Partnership initially focuses on high-complexity modeling use cases.</li><li>Simulations Plus has 30 years of expertise in pharmaceutical modeling.</li></ul>
  </section>

  <section data-block="trading-thesis">
    <h3>Trading Thesis</h3>
    <p>Investor sentiment could turn positive on SLP due to the NVIDIA partnership, driving share price up over the next 12 months.</p>
  </section>
</section>


<p xmlns="http://www.w3.org/1999/xhtml" class="bwalignc">
<i xmlns="http://www.w3.org/1999/xhtml">Combines validated scientific engines with accelerated computing and AI to enable more scalable, integrated modeling workflows across the drug development lifecycle</i>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/quote/SLP">SLP</a>) ("Simulations Plus" or the "Company"), a global leader in model-informed and AI-accelerated drug development that advances biopharma innovation, today announced the launch of a technical collaboration with NVIDIA focused on enabling GPU-accelerated simulation and AI-assisted workflows for computationally intensive modeling applications within the drug development lifecycle.

</p><p xmlns="http://www.w3.org/1999/xhtml">
The collaboration brings together Simulations Plus' validated scientific engines across physiologically-based pharmacokinetics (PBPK), pharmacokinetics/pharmacodynamics (PK/PD), and quantitative systems pharmacology (QSP) with NVIDIA AI infrastructure to accelerate and scale simulation cycles, parameter exploration, and virtual population studies. Together, these capabilities address two core constraints in model-informed drug development (MIDD): reducing manual, expertise-driven work and enabling large-scale exploration of model structures and parameters in parallel—shifting modeling from a sequential process to a more iterative, data-informed workflow operating at program-relevant timelines.

</p><p xmlns="http://www.w3.org/1999/xhtml">
NVIDIA contributes advanced computing infrastructure and expertise in accelerated inference and GPU-native optimization to improve simulation performance and enable interactive, AI-assisted workflows. NVIDIA also brings access to its life sciences ecosystem, including the <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.nvidia.com%2Fen-us%2Findustries%2Fhealthcare-life-sciences%2F&amp;esheet=54529559&amp;newsitemid=20260506350085&amp;lan=en-US&amp;anchor=NVIDIA&amp;index=1&amp;md5=97d484cfcc7e97008837ed79f5a0fe36" shape="rect">NVIDIA </a><a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.nvidia.com%2Fen-us%2Findustries%2Fhealthcare-life-sciences%2F&amp;esheet=54529559&amp;newsitemid=20260506350085&amp;lan=en-US&amp;anchor=BioNeMo+platform&amp;index=2&amp;md5=470974ed5dc59b09cce8058079f38074" shape="rect">BioNeMo platform</a> and a global network of pharmaceutical partners, supporting broader engagement and adoption.

</p><p xmlns="http://www.w3.org/1999/xhtml">
"For three decades, Simulations Plus has helped pharmaceutical and biotechnology organizations apply modeling and simulation with confidence across drug development. Our collaboration with NVIDIA brings together validated science, accelerated computing, and AI capabilities in a way that expands what scientific teams are able to explore and accomplish," said Shawn O'Connor, Chief Executive Officer of Simulations Plus.

</p><p xmlns="http://www.w3.org/1999/xhtml">
The collaboration is initially focused on three areas:

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Next-generation scientific engines</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus has begun developing GPU-optimized simulation capabilities for QSP and PK/PD applications, reducing runtimes and enabling broader exploration of complex biological systems. This enables scientists to evaluate a broader range of hypotheses without pre-pruning models, increasing confidence in model selection and supporting more robust program decisions.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">AI-assisted scientific workflows</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus is applying AI-assisted approaches, informed by NVIDIA's expertise in accelerated inference and agentic AI, to support model construction, parameter fitting, diagnostics, and refinement—reducing manual effort and accelerating iteration from question to analysis. By reducing manual, time-intensive steps, these workflows will allow scientists to focus more on scientific interpretation and decision-making, significantly accelerating iteration cycles within drug development programs.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Advancing quantitative systems pharmacology</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus is prioritizing QSP workflows—one of the most computationally demanding areas in drug development—by applying GPU acceleration and AI-assisted methods to improve simulation efficiency and expand practical use in pharmaceutical R&amp;D. Current testing shows up to a 75% reduction in time required for end-to-end QSP modeling, enabling faster iteration and expanding the practical use of QSP within program timelines.

</p><p xmlns="http://www.w3.org/1999/xhtml">
As part of the collaboration, the companies plan to engage select pharmaceutical partners to evaluate these capabilities in real-world drug development workflows, with initial focus on high-complexity modeling use cases.

</p><p xmlns="http://www.w3.org/1999/xhtml">
"Scientific teams are asking for faster iteration, greater scale, and better ways to work across increasingly complex modeling problems. By combining our validated scientific engines with AI-assisted workflows and accelerated computing, we are extending our platform into a more integrated modeling ecosystem—where workflows scale across domains like QSP while remaining grounded in reproducible, scientifically validated outputs," said Erik Guffrey, Co-Chief Product and Technology Officer of Simulations Plus.

</p><p xmlns="http://www.w3.org/1999/xhtml">
"Biopharma teams need platforms that can connect mechanistic modeling, AI, and high-performance simulation into workflows scientists can actually use. By bringing NVIDIA accelerated computing and AI infrastructure together with Simulations Plus' deep expertise in model-informed drug development, we can help researchers run more complex models, explore larger design spaces, and move from insight to decision faster,&#34; said Anthony Costa, Director of Digital Biology and Health, NVIDIA.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">About Simulations Plus, Inc.</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Simulations Plus is a global leader in model-informed and AI-accelerated drug development. We create value for our clients by accelerating the discovery, development, and commercialization of pharmaceuticals and other products through innovative science-based software and consulting solutions. For more information, visit <a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.simulations-plus.com&amp;esheet=54529559&amp;newsitemid=20260506350085&amp;lan=en-US&amp;anchor=www.simulations-plus.com&amp;index=3&amp;md5=529b4be1d4e7c5b7ef52a9cf75defa60" shape="rect">www.simulations-plus.com</a>.

</p><p xmlns="http://www.w3.org/1999/xhtml">
<b xmlns="http://www.w3.org/1999/xhtml">Forward-Looking Statements</b>

</p><p xmlns="http://www.w3.org/1999/xhtml">
Except for historical information, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties. Words like "believe," "will," "can," "expect," "anticipate" and similar expressions (or the negative of such terms, as well as other words or expressions referencing future events, conditions or circumstances) mean that these are our best estimates as of this writing, but there can be no assurances that expected or anticipated results or events will actually take place, so our actual future results could differ significantly from those statements. Factors that could cause or contribute to such differences include, but are not limited to: effectiveness of our new operational structure, our ability to maintain our competitive advantages, acceptance of new software and improved versions of our existing software by our customers, the general economics of the pharmaceutical industry, our ability to finance growth, our ability to continue to attract and retain highly qualified technical staff, market conditions, macroeconomic factors, and a sustainable market. Further information on our risk factors is contained in our quarterly, annual and current reports and filed with the U.S. Securities and Exchange Commission.

</p><p xmlns="http://www.w3.org/1999/xhtml"><img xmlns="http://www.w3.org/1999/xhtml" alt="" src="https://cts.businesswire.com/ct/CT?id=bwnews&amp;sty=20260506350085r1&amp;sid=benz2&amp;distro=nx&amp;lang=en" style="width:0;height:0"></img><span xmlns="http://www.w3.org/1999/xhtml" class="bwct31415"></span></p><p xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink"><span xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink-phrase">View source version on businesswire.com: </span><span xmlns="http://www.w3.org/1999/xhtml" id="mmgallerylink-link"><a xmlns="http://www.w3.org/1999/xhtml" href="https://www.businesswire.com/news/home/20260506350085/en/" rel="nofollow">https://www.businesswire.com/news/home/20260506350085/en/</a></span></p><p xmlns="http://www.w3.org/1999/xhtml">
Financial Profiles
<br xmlns="http://www.w3.org/1999/xhtml"></br>Lisa Fortuna
<br xmlns="http://www.w3.org/1999/xhtml"></br>310-622-8251
<br xmlns="http://www.w3.org/1999/xhtml"></br><a xmlns="http://www.w3.org/1999/xhtml" rel="nofollow" href="mailto:slp@finprofiles.com" shape="rect">slp@finprofiles.com</a>

</p>

Simulations Plus has entered a collaboration with NVIDIA to enhance drug development through AI and GPU-accelerated simulations, significantly reducing modeling time. This may lead to improved decision-making and increased adoptions of Simulations Plus' solutions within the pharmaceutical industry.

Simulations Plus and NVIDIA Collaborate to Scale GPU-Accelerated, AI-Assisted Modeling Workflows

AI Summary

Sentiment Rationale

Trading Thesis

Market-Moving

Key Facts

Companies Mentioned

Corporate Developments

Related News