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Tiziana Life Sciences Announces New Biomarker Data Showing Nasal Foralumab Downregulates CSF Inflammation, Upregulates Neuroprotective Pathways, and Correlates with Reduced Microglial Activation on PET Scans in na-SPMS Patients with PIRA

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BOSTON, Feb. 25, 2026 (GLOBE NEWSWIRE) -- Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) (“Tiziana”), a ...

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AI Summary

Tiziana Life Sciences announced promising biomarker results for nasal foralumab in treating non-active secondary progressive multiple sclerosis. The therapy demonstrated a reduction in neuroinflammation and correlated with positive clinical outcomes, paving the way for upcoming trial data in mid-2026.

Sentiment Rationale

Positive trial data historically has led to significant stock price increases for biotech firms, as seen with companies like Biogen and Amgen following favorable study results.

Trading Thesis

TLSA is likely to see near-term price appreciation as clinical data solidifies.

Market-Moving

  • Positive trial data could lead to increased investor confidence in TLSA.
  • Successful Phase 2a results may boost market interest and drive stock price up.
  • The unique intranasal delivery mechanism distinguishes TLSA's therapy from competitors.
  • Robust correlations in biomarker data may enhance the company's valuation.

Key Facts

  • TLSA's nasal foralumab shows promise by reducing CNS inflammation.
  • New biomarker data confirms efficacy in multiple sclerosis treatment.
  • Clinical stabilization achieved with no serious adverse events reported.
  • Strong correlation between PET scans and CSF proteomic changes observed.
  • Phase 2a trial results expected in first half of 2026.

Companies Mentioned

  • Brigham and Women's Hospital (N/A): Pivotal role in conducting research on TLSA's nasal foralumab.

Corporate Developments

This article falls under Corporate Developments as it reports significant clinical results for Tiziana's lead drug candidate, which has critical implications for its future growth and valuation.

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