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Anixa Advances FSHR CAR-T Trial to Highest Dose with Positive Survival Signals

Jul 6, 2026, 8:35 AM EDT1 sourcesAI-analyzed
Why it may matterVerify against the original reporting

Early-stage safety improves; OS-like signals in a hard-to-treat population could attract investor attention and potential upside if corroborated by additional cohorts.

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What happened, with direct paths to the underlying reporting

Anixa announced the first patient in Cohort 5 was dosed at the highest level (1x10^7 CAR-positive cells/kg) in its FSHR-targeted CAR-T trial for recurrent ovarian cancer at Moffitt. With no dose-limiting toxicities and five patients surviving over a year (one beyond two years), the data offer an early but meaningful safety/efficacy signal that could accelerate enrollment and upcoming milestones.

  • First patient treated in Cohort 5 of FSHR CAR-T trial.
  • Dose: 1x10^7 CAR-positive cells/kg after lymphodepletion; no DLTs observed.
  • Five patients survived beyond one year; one beyond two years.
  • Trial at Moffitt Cancer Center (NCT05316129) evaluates lira-cel CER-T for recurrent ovarian cancer.

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