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The data de-risks the TPIP program, reinforces clinical benefit signals, and supports a near-term Phase 3 pathway, which can lift valuation and attract investor attention ahead of PALM-PAH milestones.
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Insmed announced positive 12-month data from TPIP’s open-label extension in PAH, showing sustained improvements in 6MWD, NT-proBNP, WHO Functional Class, and REVEAL Lite 2.0 risk scores, with placebo-crossed patients achieving similar outcomes. Safety remained acceptable up to 1,280 µg daily; PALM-PAH Phase 3 is underway, potentially accelerating TPIP’s approval pathway.
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