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Arcus and Summit to test HIF-2α plus PD-1/VEGF in ccRCC with mid-2027 data

Jul 22, 2026, 4:38 PM EDT1 sourcesAI-analyzed
Why it may matterVerify against the original reporting

A credible collaboration around a backbone HIF-2α inhibitor plus a novel PD-1/VEGF bispecific could expand RCC treatment paradigms; mid-2027 data provide a tangible catalyst, though outcome risk remains; positive signals may elevate sentiment for SMMT.

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What happened, with direct paths to the underlying reporting

Arcus Biosciences and Summit Therapeutics announced a clinical trial collaboration to evaluate Arcus's casdatifan with Summit's ivonescimab in clear cell renal cell carcinoma, including first-line metastatic disease. Initial ARC-20 data is expected by mid-2027, with PEAK-1 enrollment ending in 2026 and a first-line Phase 3 planned by year-end 2026. A successful readout could boost ivonescimab's RCC potential and benefit SMMT as the program advances.

  • Arcus and Summit launch ccRCC trial of casdatifan + ivonescimab. Data due mid-2027.
  • Summit supplies ivonescimab. Arcus sponsors; costs shared; rights unchanged.
  • PEAK-1 enrollment ends 2026; first-line metastatic ccRCC Phase 3 planned by year-end 2026.
  • About kidney cancer: 80,450 US cases in 2026; metastatic five-year survival 19%.
  • Ivonescimab targets PD-1/VEGF. Casdatifan aims as backbone therapy across lines.

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