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Inhibrx's INBRX-106 shows strong HPV+ responses; accelerated path possible

Sep 8, 2026, 7:36 AM EDT1 sourcesAI-analyzed

Why it may matterVerify against the original reporting

Strong efficacy signals in a randomized setting, especially in HPV+ patients, plus an accelerated pathway potential and Phase 3 advancement could drive a re-rating of INBX on upside scenarios; risk remains until confirmatory Phase 3 data and regulatory positioning.

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Inhibrx reported Phase 2 HexAgon results for INBRX-106 plus pembrolizumab in first-line HNSCC, with cORR 48.3% and 6-month PFS 72.4% versus pembrolizumab alone. HPV+ patients driven outperformance (80% cORR, 30% CR, 90% PFS6). The company plans a ~50-patient HPV+ OPSCC expansion to pursue accelerated regulatory pathways and will advance to Phase 3, while a NSCLC perioperative readout is due mid-2027.

INBRX-106 + pembrolizumab: cORR 48.3%, 6-month PFS 72.4%.
HPV+ cohort: cORR 80%, CR 30%, PFS6 90%.
Phase 2 expansion planned for ~50 HPV+ OPSCC patients for accelerated pathway.
Phase 3 planned after expansion; broader immunogenic tumor exploration ongoing.
NSCLC perioperative trial readout targeted for mid-2027.

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