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Evotec Advances Orthopoxvirus Antibody Program to Phase 1, Highlights DoD Collaboration

Sep 9, 2026, 2:21 AM EDT1 sourcesAI-analyzed

Why it may matterVerify against the original reporting

Phase 1 progression and DoD-backed contracts create potential revenue upside. However, as a development-stage program, immediate material cash flow remains uncertain; the impact hinges on later-stage data and contract execution, as seen in prior defense collaborations with biotech firms.

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Evotec SE announced that its Just–Evotec Biologics unit has initiated a first-in-human Phase 1 trial for JST-018, an antibody cocktail targeting orthopoxviruses under the Accelerated Antibodies Program. The project integrates rapid development and continuous manufacturing at J.POD Redmond, aligning with a DoD contract with potential total value up to $123.9 million across orthopoxvirus and plague programs. A successful Phase 1 could unlock additional biodefense partnerships and revenue opportunities.

Just–Evotec Biologics starts Phase 1 for JST-018 orthopoxvirus antibodies.
Manufacturing completed at J.POD Redmond using continuous bioprocessing.
Combined DoD contracts for orthopoxvirus and plague up to $123.9M.
Milestone demonstrates integrated manufacturing model for biodefense readiness.

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