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High materiality7/10

Eloxx Doses First Patients in EXACT Phase 2b NMAS Trial with 2027 Readouts

Sep 11, 2026, 7:45 AM EDT1 sourcesAI-analyzed

Why it may matterVerify against the original reporting

Initial dosing signals program progression; positive sentiment may lift ELOX near-term, though data risk remains until 2027 toplines.

AI summary

What happened, with direct paths to the underlying reporting

Eloxx announced the first two patients were dosed in the EXACT Phase 2b trial of exaluren for nonsense mutation Alport syndrome (NMAS). Topline results are slated for mid-2027, with a final readout by year-end 2027. This milestone underlines unmet NMAS needs and may unlock orphan-drug incentives and potential milestone payments from Almirall, influencing long-term valuation if efficacy is demonstrated.

First two patients dosed in EXACT Phase 2b NMAS trial.
Topline data expected mid-2027; final readout by end-2027.
EXACT: 24-patient, randomized, placebo-controlled, delayed-start design.
Orphan designation for exaluren; potential Almirall milestones may arise.

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