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LEGNBullishIndustry Newsnews
High materiality8/10

Legend Biotech's CARVYKTI Demonstrates Five-Year Durability in Earlier-Line RRMM

Sep 25, 2026, 7:51 AM EDT1 sourcesAI-analyzed
Why it may matterVerify against the original reporting

Strong long-term durability signals and potential earlier-line label expansion could attract buyers and reposition LEGN in the CAR-T market, though near-term FDA/payer dynamics and safety considerations temper enthusiasm.

AI summary

What happened, with direct paths to the underlying reporting

Legend Biotech reported five-year CARTITUDE-2 Cohort A results for CARTVYKTI in earlier-line RRMM, with 50% progression-free alive at ≥5 years and a median PFS of 60.5 months. While OS is not yet reached, durability signals potential for earlier use to achieve long-term disease control, supporting upside if regulatory and payer conditions align for label expansion.

  • Five-year CARTITUDE-2 Cohort A results show 69.2% OS at five years.
  • 50% of patients remain alive and progression-free ≥5 years after a single CARVYKTI infusion.
  • Median PFS is 60.5 months; OS not reached at analysis.
  • No new CAR-T neurotoxicity; one AML case and two deaths since prior analysis.

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