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Promising mechanistic data reducing delivery risk and suggesting systemic administration could expand the addressable market for a KRAS-targeted RNAi therapy. While preclinical, such translational validation often precedes clinical readouts and can trigger short-term upside if investors interpret it as de-risking the program.
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Silexion Therapeutics reported translational results showing SIL204 uses circulating lipoproteins for intracellular delivery, achieving dose-dependent KRAS knockdown. Findings imply physiological lipids suffice for cellular entry, potentially enabling systemic subcutaneous administration in the Phase 2/3 program for locally advanced pancreatic cancer. Regulatory site initiations progress in Israel and Germany, supporting the broader clinical strategy.
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