Entrada Therapeutics advances Elevate-44-201 with Cohort 3 top-dose decision
Oct 14, 2026, 7:18 AM EDT2 sourcesAI-analyzed
Why it may matterVerify against the original reporting
Progress in dose escalation and timely readouts often improves perceived program momentum, potentially supporting TRDA shares if safety data remain favorable and interim efficacy signals emerge.
AI summary
What happened, with direct paths to the underlying reporting
Entrada Therapeutics announced that an independent Data Monitoring Committee reviewed safety and PK data from eight Cohort 2 participants and recommended initiating Cohort 3 at 18 mg/kg. Cohort 2 enrollment is complete, with data expected in Q1 2027; Cohort 1 open-label data are due by year-end 2026. These developments mark near-term trial progression catalysts for TRDA’s Elevate-44-201 program.
DMC reviewed safety/PK data from eight Cohort 2 participants.
Cohort 3 top dose set at 18 mg/kg; vs 12 mg/kg Cohort 2.
Cohort 2 enrollment complete; data expected Q1 2027.
Open-label Cohort 1 data expected by year-end 2026.
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