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NBTX Shows Promising Phase 1 Melanoma Signals; Supports Further Trials

Oct 24, 2026, 7:11 AM EDT1 sourcesAI-analyzed
Why it may matterVerify against the original reporting

Positive ORR/DCR and a non-trivial OS metric in a PD-1–resistant setting can lift near-term equity sentiment; IL-1β signal adds a potential biomarker angle, though the data is early and lacks randomized confirmation.

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What happened, with direct paths to the underlying reporting

NBTX announced updated Phase 1 results from Study 1100 in anti-PD-1-resistant primary cutaneous melanoma. ORR reached 41.7% (10/24) with 4 complete responses and a 75% disease control rate; median overall survival was 17.8 months. An exploratory analysis noted a rise in IL-1β, suggesting potential immunologic reactivity, and investigators called for randomized trials in PD-1 naïve or refractory patients.

  • NBTX reports updated Phase 1 results in anti-PD-1-resistant melanoma.
  • ORR 41.7% (10/24); 4 complete responses; DCR 75% (18/24); median OS 17.8 months.
  • Exploratory IL-1β increase observed post-treatment; warrants randomized trials.
  • Data presented at 2026 ESMO Congress; potential PD-1 naïve/refractory melanoma trials.
  • Cross-listed on NASDAQ (NBTX) and Euronext (NANO); near-term price sensitivity.

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