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Amgen real-world study shows Repatha reduces MI risk 20% vs ezetimibe

Nov 5, 2026, 9:26 AM EST1 sourcesAI-analyzed

Why it may matterVerify against the original reporting

Large-scale real-world evidence favoring Repatha against a widely used non-statin option could boost physician prescribing, payer confidence, and near-term AMGN sentiment, especially with supportive regulatory context and pricing/coverage leverage highlighted in the release.

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Amgen unveiled a large real-world analysis comparing outcomes for ASCVD patients started on Repatha or ezetimibe. Evolocumab reduced fatal or nonfatal MI by 20% over up to four years, across more than 544,000 adults. The findings strengthen non-statin LDL-C management evidence, potentially boosting Repatha uptake and payer support in the near term.

Amgen real-world study shows Repatha lowers fatal/nonfatal MI vs ezetimibe by 20%.
544,103 ASCVD adults followed four years; results published in Am J Prev Cardiol.
Among 225,048 with baseline LDL-C, 4-year MI risk: 5.88% Repatha vs 7.76%.
The study leverages Komodo data with active-comparator/new-user design.
Informs non-statin ASCVD treatment decisions; expands evidence base.

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