1. RCUS discontinued Phase 3 STAR-221 study due to futility recommendations. 2. Stock performance suffers with an 11.10% decline post-announcement. 3. Focus shifts to casdatifan for clear cell renal cell carcinoma (ccRCC). 4. Company plans incremental data releases for casdatifan through 2026-2027. 5. Safety profile of STAR-221 treatment was similar to existing treatments.