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Inspira Achieves above 99% Gas Exchange Efficiency in VORTX™ Technology In-Vivo Animal Testing

1. Inspira announces major milestone in VORTX technology testing. 2. VORTX achieved over 99% gas exchange in in-vivo testing. 3. The technology aims to revolutionize acute respiratory care. 4. Inspira plans further evaluation and development updates soon. 5. Technology reduces blood trauma compared to traditional methods.

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FAQ

Why Very Bullish?

The successful testing of VORTX technology positions IINN favorably in the medical technology market, similar to how prior medical breakthroughs have positively influenced stock movements. Investor sentiment may improve significantly with the anticipation of regulatory approvals and market entry.

How important is it?

The focus on innovation and successful testing in a crucial medical field indicates strong potential for stock appreciation, thus warranting a high importance score.

Why Long Term?

Long-term success will depend on regulatory approvals and market introduction of the VORTX technology, akin to past medical technology firms that gained significant market share over time.

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INSPZIOPMDVL
RA'ANANA, Israel, April 23, 2025 (GLOBE NEWSWIRE) -- Inspira™ Technologies OXY B.H.N. Ltd. (Nasdaq: IINN, IINNW) ("Inspira" or the "Company"), a pioneer in innovative life-support and diagnostic technologies, today announced a major milestone achievement in the in-vivo testing of its next-generation VORTX™ technology. This breakthrough innovation is uniquely designed to oxygenate blood effectively without the trauma associated with conventional hollow fiber technologies. The in vivo testing achieved above 99% gas exchange target at a defined flow rate. The VORTX technology, slated for integration into Inspira’s pipeline, including the INSPIRA ART500, aims to transform acute respiratory care, providing an advanced alternative for patients who might otherwise require invasive mechanical ventilation. The distinctive design of the VORTX is meant to ensure a zero-pressure difference during the oxygenation process, potentially reducing levels of harmful blood trauma, a prevalent limitation in traditional fiber-based oxygenators. This critical in-vivo experiment was conducted with an 80 kg swine at the renowned Institute of Animal Research, Israel's premier large-animal preclinical research facility, as part of an Israel Innovation Authority ("IIA")-funded initiative. The trial successfully confirmed prior lab-based findings, demonstrating proof-of-concept, scalability, and validating Inspira's continued progress toward its key development objectives. "We are extremely proud to achieve this major technological milestone," stated Dagi Ben-Noon, Chief Executive Officer of Inspira Technologies. "I believe that the VORTX technology represents a significant leap forward in blood oxygenation, and successfully achieving this milestone within an IIA-funded framework underscores our team's innovative capabilities and strengthens our commitment to advancing life-support technology." Inspira plans to further evaluate and refine the VORTX oxygen delivery technology, with additional results and development updates anticipated in the near future. About Inspira Technologies Inspira Technologies is developing innovative respiratory support and diagnostics technologies. The Company's flagship INSPIRA ART500 system also known as the INSPIRA ART aims to revolutionize critical care by enabling patients to remain awake during treatment while stabilizing oxygen levels without mechanical ventilation. The FDA-cleared INSPIRA ART100 system has received regulatory approvals for Cardiopulmonary Bypass procedures in both the U.S. and for Cardiopulmonary Bypass procedures and Extra Corporeal Membrane Oxygenation in Israel. The Company's HYLA™ blood sensor technology is designed to provide continuous, real-time blood monitoring without the need for blood draws. The Company's pipeline products, including the INSPIRA ART500, and HYLA blood sensor, are currently in development and have not yet received regulatory approval. For more information, please visit our corporate website at https://inspira-technologies.com. Forward-Looking Statement Disclaimer This press release contains express or implied forward-looking statements pursuant to U.S. Federal securities laws. These forward-looking statements are based on the current expectations of the management of the Company only and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. For example, the Company is using forward-looking statements when it discusses the potential benefits of the products and designs of the Company’s products and technologies, including its VORTX technology, the believe that the VORTX™ technology represents a significant leap forward in blood oxygenation, and successfully achieving this milestone within an IIA-funded framework underscores its innovative capabilities and strengthens its commitment to advancing life-support technology, its plan to evaluate and refine the VORTX technology and that it expects to share additional results and development updates in the near future. These forward-looking statements and their implications are based solely on the current expectations of the Company's management and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. Except as otherwise required by law, the Company undertakes no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. More detailed information about the risks and uncertainties affecting the Company is contained under the heading "Risk Factors" in the Company's annual report on Form 20-F for the fiscal year ended December 31, 2024, filed with the U.S. Securities and Exchange Commission (the "SEC"), which is available on the SEC's website at www.sec.gov. Company ContactInspira Technologies – Media RelationsEmail: info@inspirao2.comPhone: +972-9-9664485 Capital Markets & Investor ContactArx | Capital Markets AdvisorsNorth American Equities Deskinspira@arxadvisory.com

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