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Metsera to Present New Research Highlighting the Breadth and Momentum of its Next-Generation Obesity Portfolio at the 85th Scientific Sessions of the American Diabetes Association®

1. Metsera presents MET-097i at American Diabetes Association meeting. 2. Clinical data shows weight change and tolerability for MET-097i. 3. MET-233i and other preclinical programs also highlighted. 4. The company emphasizes scalable treatments for obesity. 5. Future prospects appear promising with diverse portfolio.

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Why Bullish?

Positive clinical data and preclinical assets suggest strong growth potential for MTSR. Historical examples include stocks like Novo Nordisk seeing price increases following successful trial results.

How important is it?

Data revealed can significantly guide investor sentiment and market interest in MTSR’s future developments.

Why Long Term?

Commercialization of successful treatments may take time. Long-term growth observed in similar biopharmaceutical companies after positive trial outcomes.

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June 05, 2025 07:30 ET  | Source: Metsera, Inc. Four presentations on MET-097i, a fully biased, monthly, ultra-long acting GLP-1 receptor agonist, including two clinical data presentations Additional preclinical presentations on other differentiated portfolio assets, including MET-233i, a monthly, ultra-long acting amylin analog NEW YORK, June 05, 2025 (GLOBE NEWSWIRE) -- Metsera, Inc. (Nasdaq: MTSR), a clinical-stage biopharmaceutical company accelerating the next generation of medicines for obesity and metabolic diseases, will highlight the breadth and momentum of its portfolio of ultra-long acting, scalable, and combinable therapies, including updated clinical and preclinical findings from lead program MET-097i, at the 85th Scientific Sessions of the American Diabetes Association® (ADA). “We look forward to presenting work spanning our portfolio to the scientific community at this year’s ADA meeting,” said Whit Bernard, Chief Executive Officer of Metsera. “Our presentations, including clinical data from the completed Phase 1/2 trial of MET-097i and preclinical findings for our other programs, showcase the breadth of our next-generation approaches to address the need for scalable and differentiated treatments for overweight and obesity.” Presentation Highlights MET-097i: A fully biased, ultra-long acting GLP-1 receptor agonist MET-097i is Metsera’s fully biased, monthly, ultra-long acting GLP-1 receptor agonist. Metsera will present clinical data from MET-097i’s Phase 1/2 clinical trial in two presentations, including change in body weight and tolerability data after twelve weekly doses and after a single candidate monthly dose. MET-233i: An ultra-long acting amylin analog MET-233i is Metsera’s monthly, ultra-long acting amylin analog. Metsera will present preclinical data, including detailed pharmacokinetic and change in body weight data. Presentation Details: MET-097i: A fully biased ultra-long acting GLP-1 receptor agonist Clinical data Title: A Twelve-Week Trial of MET-097—A Potent and Ultra-Long-Acting GLP-1 Receptor Agonist (788-P)Session: Sunday General Poster SessionPresenter: Robert Stoekenbroek, M.D., Ph.D., Head of Portfolio Strategy at Metsera Time/Date: Sunday, June 22; 12:30-1:30pm CDTLocation: Poster Hall (Hall F1), 122 Title: Safety, Tolerability, PK, and Efficacy of MET-097—A Next-Generation Nutrient-Stimulated Hormone Peptide Analog for Chronic Weight Management (753-P)Session: Sunday General Poster SessionPresenter: Steve Marso, M.D., Chief Medical Officer at MetseraTime/Date: Sunday, June 22; 12:30-1:30pm CDTLocation: Poster Hall (Hall F1), 088 Preclinical data Title: MET-097: Preclinical Characterization of a Potent and Ultra-Long-Acting GLP-1 Receptor Agonist (794-P)Session: Sunday General Poster SessionPresenter: Charlotte Hinds, Ph.D., Senior Director, Research & Development at MetseraTime/Date: Sunday, June 22; 12:30-1:30pm CDTLocation: Poster Hall (Hall F1), 128 Title: Cellular Characterisation of Signalling and Receptor Trafficking Induced by MET-097, a G Protein-Biased GLP-1R Agonist (799-P)Session: Sunday General Poster SessionPresenter: Billy Peter Baxter, Ph.D., Imperial College LondonTime/Date: Sunday, June 22; 12:30-1:30pm CDTLocation: Poster Hall (Hall F1), 133 MET-233: An ultra-long acting amylin analog Preclinical data Title: MET-233 Is an Ultra-Long-Acting Amylin Receptor Agonist (894-P)Session: Sunday General Poster SessionPresenter: James S Minnion, Ph.D., Vice President, Research & Development at MetseraTime/Date: Sunday, June 22; 12:30-1:30pm CDTLocation: Poster Hall (Hall F1), 190 Pipeline programs Preclinical data Title: Therapeutic NuSH Cocktails—Coadministration of Ultra-Long-Acting GLP-1, GIP, Glucagon, and Amylin Peptide Analogs Induce Profound Weight Loss in DIO Mice (765-P)Session: Sunday General Poster SessionPresenter: Robert Hansford, Ph.D., Preclinical Research Scientist at MetseraTime/Date: Sunday, June 22; 12:30-1:30pm CDTLocation: Poster Hall (Hall F1), 100 Health Economics and Outcomes Research Title: Titration to Maintenance Doses of GLP-1R Agonists for Overweight and Obesity Is Suboptimal for Majority of Patients—Evidence from a Real-World Claims Dataset (758-P)Session: Sunday General Poster SessionPresenter: Shannon Armstrong, Vice President, Global Value and Access at MetseraTime/Date: Sunday, June 22; 12:30-1:30pm CDTLocation: Poster Hall (Hall F1), 093 For more information about Metsera’s presence at ADA, visit https://metsera.com/ada/. About Metsera Metsera is a clinical-stage biopharmaceutical company accelerating the next generation of medicines for obesity and metabolic diseases. Metsera is advancing a broad portfolio of oral and injectable incretin, non-incretin and combination therapies with potential best-in-class profiles to address multiple therapeutic targets and meet the future needs of a rapidly evolving weight loss treatment landscape. Metsera was founded in 2022 and is based in New York City. For more information, please visit us at www.metsera.com and follow us on LinkedIn and X. Metsera may use its website as a distribution channel of material information about the Company. Financial and other important information regarding the Company is routinely posted on and accessible through the Investors & News section of its website at investors.metsera.com. In addition, you may sign up to automatically receive email alerts and other information about the Company by using the “Email Alerts” option on the Investors & Media page and submitting your email address. Forward-Looking Statements This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the "Act"). Examples of such statements include, but are not limited to, statements relating to Metsera's expectations regarding participation and presentations at the 85th Scientific Sessions of the American Diabetes Association® (ADA), its research and development activities, and statements regarding the efficacy, safety and potential regulatory progress of its investigational candidates. Such statements are based on management's current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to the risks related to Metsera’s business outlined in Metsera’s filings with the Securities and Exchange Commission, including in the “Risk Factors” section of its Annual Report on Form 10-K for the year ended December 31, 2024. Forward-looking statements are not guarantees of future performance, and Metsera’s actual results of operations, financial condition and liquidity, and the development of the industry in which it operates, may differ materially from the forward-looking statements contained in this press release. Any forward-looking statements that Metsera makes in this press release speak only as of the date of this press release. Metsera assumes no obligation to update its forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release. Contact:Jono EmmettMetseramedia@metsera.com

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