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NorthStrive Biosciences Announces Completion of Phase I Strategic Review for EL-22 Targeting Muscle Loss Associated with GLP-1 Weight Loss Drugs and Age-Related Sarcopenia

1. Northstrive completed Phase I research on their probiotic EL-22. 2. EL-22 targets muscle-wasting conditions and obesity with myostatin engineering. 3. A novel oral delivery method could enhance patient compliance and safety. 4. Strategic Phase 2 trials focus on GLP-1 users for muscle preservation. 5. Partnership with Yuva Biosciences aids in advanced AI-supported analysis.

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Why Bullish?

EL-22 represents innovation in muscle-wasting treatment, benefitting from current obesity trends. Historical examples show that novel therapeutic approaches often lead to stock price gains.

How important is it?

The announcement of Phase I completion and plans for Phase II trials indicate significant progress for EL-22, likely leading to increased investor interest.

Why Long Term?

The potential FDA approval process and subsequent market introduction of EL-22 will take significant time, signaling a longer timeline for potential price impact.

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PMGCYVBI
NEWPORT BEACH, Calif., May 22, 2025 (GLOBE NEWSWIRE) -- Northstrive Biosciences Inc. (“Northstrive”), a subsidiary of PMGC Holdings Inc. (NASDAQ: ELAB) (the “Company,” “PMGC,” “we,” or “our”), today announced the completion of a Phase I strategic research and literature synthesis for EL-22 (formerly BLS-M22), its first-in-class oral myostatin-engineered probiotic. The analysis, conducted in collaboration with Yuva Biosciences and supported by AI-based scientific review technology from Yuva Biosciences’ MitoNova™, provided valuable insights into EL-22’s proposed mechanism of action and will help guide further exploration into its potential to address critical unmet needs in muscle-wasting conditions, including GLP-1-associated atrophy and age-related sarcopenia. EL-22 is leveraging a myostatin-engineered probiotic approach to address obesity’s pressing issue of preserving muscle while on weight loss treatments, including GLP-1 receptor agonists. The oral biologic is designed to induce a targeted immune response against myostatin, a key negative regulator of muscle growth. Unlike traditional injectable antibodies, EL-22 leverages genetically engineered Lactobacillus casei to stimulate the gut immune system, offering a convenient, patient-friendly oral delivery method with potential safety and efficacy advantages. Key Highlights from the Report: Strong Preclinical Rationale: Synthesized findings from published peer-reviewed literature, highlight noteworthy effects of EL-22 in mdx mice on antibody production, serum CK, body weight, motor function, and muscle histology.Unique Oral Vaccine Approach: EL-22 is distinct from the more common systemic administration of antibodies or gene therapy vectors. Utilizing Lactobacillus casei as a delivery vehicle to stimulate mucosal and systemic immunity against myostatin is a novel immunological strategy for a muscle-wasting disorder.Targeting GLP-1-Associated Muscle Loss: With the rapid expansion of GLP-1 receptor agonists in obesity and diabetes, EL-22 is well-positioned to address the growing concern of associated muscle loss. The company is prioritizing this indication for its next clinical development milestone.Strategic Next Steps: NorthStrive intends to launch a Phase 2 proof-of-concept trial targeting GLP-1 users and begin regulatory engagement to advance EL-22 toward an IND filing in the United States. About Northstrive Biosciences Inc. Northstrive Biosciences Inc., a PMGC Holdings Inc. company, is a biopharmaceutical company focusing on the development and acquisition of cutting-edge aesthetic medicines. Northstrive’s lead asset, EL-22, leverages an engineered probiotic approach to address obesity’s pressing issue of preserving muscle while on weight loss treatments, including GLP-1 receptor agonists. For more information, please visit www.northstrivebio.com. About Yuva Biosciences, Inc. Yuva Biosciences is a longevity company harnessing the cutting edge of mitochondrial science to address the root cause of aging. By partnering with consumer brands and biotech innovators, Yuva Biosciences develops solutions for aging-related concerns including hair loss, skin wrinkles, and several other conditions driven by a decline in mitochondrial function. The company is headquartered in Birmingham, Alabama. For more information, please visit www.yuvabio.com. About PMGC Holdings Inc. PMGC Holdings Inc. is a diversified holding company that manages and grows its portfolio through strategic acquisitions, investments, and development across various industries. Currently, our portfolio consists of three wholly owned subsidiaries: Northstrive Biosciences Inc., PMGC Research Inc., and PMGC Capital LLC. We are committed to exploring opportunities in multiple sectors to maximize growth and value. For more information, please visit https://www.pmgcholdings.com. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Words such as “believes,” “expects,” “plans,” “potential,” “would” and “future” or similar expressions such as “look forward” are intended to identify forward-looking statements. Forward-looking statements are made as of the date of this press release and are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy, activities of regulators and future regulations and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Although the Company believes that the expectations expressed in these forward-looking statements are reasonable, it cannot assure you that such expectations will turn out to be correct, and the Company cautions investors that actual results may differ materially from the anticipated results. Therefore, you should not rely on any of these forward-looking statements. These and other risks are described more fully in PMGC’s filings with the United States Securities and Exchange Commission (“SEC”), including the “Risk Factors” section of the Company’s Annual Report on Form 10-K for the year ended December 31, 2024, filed with the SEC on March 28, 2025, and its other documents subsequently filed with or furnished to the SEC. Investors and security holders are urged to read these documents free of charge on the SEC’s web site at www.sec.gov. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except to the extent required by law, the Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. IR Contact: IR@pmgcholdings.com

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