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Perspective Therapeutics Presents Updated Interim Data of [212Pb]VMT-α-NET in its Ongoing Phase 1/2a Clinical Trial at the 2026 ASCO Gastrointestinal Cancers Symposium

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High Materiality9/10

Information

SEATTLE, Jan. 09, 2026 (GLOBE NEWSWIRE) -- Perspective Therapeutics, Inc. (“Perspective,” the “Compa...

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AI Summary

[212Pb]VMT-α-NET shows sustained anti-tumor activity in a Phase 1/2 trial. 39% objective response rate in Cohort 2, showing potential efficacy. No serious adverse events linked to the treatment reported so far. Regulatory engagement planned for progressing to registrational trials. Positive interim results may strengthen investor confidence in CATX.

Sentiment Rationale

The reported efficacy and safety data reinforce CATX's potential; historical cases show positive clinical trial results often precede stock price increases, suggesting upward momentum for CATX.

Trading Thesis

Ongoing clinical trials and potential regulatory discussions may positively affect CATX's valuation over time, as success in these could lead to major market entries.

Market-Moving

  • [212Pb]VMT-α-NET shows sustained anti-tumor activity in a Phase 1/2 trial.
  • 39% objective response rate in Cohort 2, showing potential efficacy.
  • No serious adverse events linked to the treatment reported so far.

Key Facts

  • [212Pb]VMT-α-NET shows sustained anti-tumor activity in a Phase 1/2 trial.
  • 39% objective response rate in Cohort 2, showing potential efficacy.
  • No serious adverse events linked to the treatment reported so far.
  • Regulatory engagement planned for progressing to registrational trials.
  • Positive interim results may strengthen investor confidence in CATX.

Companies Mentioned

  • VRTX (VRTX)
  • AMGN (AMGN)
  • MRNA (MRNA)

Research Analysis

Given CATX's focus on cancer treatments, the success of VMT-α-NET is directly impactful, warranting a high score due to the substantial implications for future trials and market positioning.

Perspective Therapeutics Reports Promising Interim Data for [212Pb]VMT-α-NET in Phase 1/2a Clinical Trial

Stock Symbol: CATX | Date: January 9, 2026 | Source: GlobeNewsWire

Overview of Updated Interim Results

On January 8, 2026, at the ASCO Gastrointestinal Cancers Symposium in San Francisco, Perspective Therapeutics, Inc. (NYSE AMERICAN: CATX) unveiled remarkable interim results from its ongoing Phase 1/2a clinical trial of [212Pb]VMT-α-NET. The trial focuses on patients diagnosed with unresectable or metastatic neuroendocrine tumors (NETs) expressing somatostatin receptor type 2 (SSTR2).

Key Highlights from the Clinical Trial

  • Interim analysis includes data from 56 patients across three dose cohorts (Cohort 1: 2.5 mCi, Cohort 2: 5.0 mCi, and Cohort 3: 6.0 mCi).
  • 39% of patients in Cohort 2 showed an objective response according to RECIST v1.1.
  • No dose-limiting toxicities (DLTs) were reported, and no treatment-related discontinuations occurred.
  • 19 of the 25 patients (76%) in the trial remained alive without disease progression.

Safety and Efficacy Analysis

The updated safety analysis confirmed that among the 56 patients, there were no significant adverse events linked to the study drug. A minority experienced Grade 3 or higher emergent adverse events (37.5%), with only a single patient experiencing a transient Grade 4 event that resolved without intervention.

The trial's efficacy assessment revealed promising results with 9 patients (39%) from Cohort 2 demonstrating an objective response, affirming the potential of [212Pb]VMT-α-NET in disease management.

Expert Opinions on Trial Findings

Dr. Vikas Prasad, a Professor of Radiology at the Mallinckrodt Institute of Radiology, stated, “With longer follow-up, we see evidence of sustained anti-tumor activity for VMT-α-NET. This supports continued dose optimization as we gather insights with evolving results.”

Markus Puhlmann, Chief Medical Officer of Perspective, added, “The results from ASCO-GI reinforce the compelling profile of VMT-α-NET. We are proceeding to enroll more patients and anticipate engaging with regulatory bodies in 2026 as we plan for a registrational trial.”

About [212Pb]VMT-α-NET

[212Pb]VMT-α-NET is designed to deliver targeted alpha-emitting isotope radiation directly to tumor cells expressing SSTR2. This ongoing multi-center study aims to demonstrate VMT-α-NET’s efficacy and safety profile in patients who have shown disease progression within the previous year and have not received prior radiopharmaceutical treatments.

Further analyses and conference presentations related to the remaining patients from Cohorts 2 and 3 are planned throughout 2026.

About Perspective Therapeutics, Inc.

Perspective Therapeutics, Inc. is at the forefront of radiopharmaceutical development, focusing on advanced therapies for various cancers. Utilizing the unique properties of the alpha-emitting isotope 212Pb, the company aims to improve treatment efficacy while minimizing toxicity through its innovative theranostic approach.

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