Rafael Holdings Reports Fourth Quarter and Full Year Fiscal 2025 Financial Results

October 29, 2025 16:24 ET | Source: Rafael Holdings, Inc. Cyclo Therapeutics’ TransportNPC™ Phase 3 clinical trial for Trappsol® Cyclo™ for the treatment of Niemann-Pick Disease Type C1, a rare and fatal genetic disease, is continuing at the recommendation of the Data Monitoring Committee (DMC) following their review of prespecified safety and efficacy date at 48 weeks On August 4, 2025, Joshua Fine was elected as the Company’s Chief Operating Officer NEWARK, N.J., Oct. 29, 2025 (GLOBE NEWSWIRE) -- Rafael Holdings, Inc. (NYSE: RFL; NYSE American: RFL-W), today reported its financial results for the fourth quarter and full fiscal year 2025 ended July 31, 2025. “We are pleased with the continued progress of our pivotal Phase 3 TransportNPC™ study evaluating Trappsol® Cyclo™ for the treatment of Niemann-Pick Disease Type C1, which we believe could provide an important new treatment for option for patients suffering from this rare and fatal genetic disease,” said Howard Jonas, Chief Executive Officer, Executive Chairman and Chairman of the Board of Rafael Holdings. Mr. Jonas added, “We enhanced our financial position with the closing of a $25 million rights offering in June, which positions our Company well to advance the Trappsol® Cyclo™ program and invest in additional opportunities we may identify. I would also like to take this opportunity to congratulate Joshua Fine on his appointment as the Company’s Chief Operating Officer, Alan Grayson on his addition to our Board of Directors and Markus Sieger on being named as Chair of our Audit Committee. I look forward to their important contributions towards advancing the Company and driving value for all stakeholders.” Rafael Holdings, Inc. Fourth Quarter Fiscal Year 2025 Financial Results As of July 31, 2025, we had cash and cash equivalents of $52.8 million. On June 4, 2025, the Company closed a $25 million rights offering, which included the funding of the backstop commitment in the amount of $21.0 million by the Jonas family. For the three months ended July 31, 2025, we recorded a net loss attributable to Rafael Holdings of $12.1 million, or $0.28 per share, versus a net loss of $4.5 million, or $0.19 per share in the year ago period. The year over year increase in net loss is attributable to the consolidation of Cyclo Therapeutic’s expenses following the acquisition of Cyclo in March 2025 and the activity of Cornerstone and Day Three which were consolidated with Rafael Holdings during fiscal 2024. Research and development expenses were $7.5 million for the three months ended July 31, 2025, compared to $1.5 million in the year ago period. The year over year increase relates to the inclusion in the current year period of spending at Cyclo following the March 2025 acquisition and the activity of Cornerstone and Day Three which were consolidated with Rafael Holdings during fiscal 2024. General and administrative expenses were $5.5 million for the three months ended July 31, 2025, compared to $2.3 million in the year ago period. The year over year increase relates to the inclusion of expenses at Cyclo following closing of the acquisition, and the activity of Cornerstone and Day Three, following their consolidation. Rafael Holdings, Inc. Full Year Fiscal Year 2025 Financial Results For the twelve months ended July 31, 2025, we recorded a net loss attributable to Rafael Holdings of $30.5 million, or $1.04 per share, versus a net loss of $34.4 million, or $1.45 per share in the year ago period. The year over year decrease in net loss is attributable to in-process R&D expense of $89.9 million related to the acquisition (when we increased our ownership position) of Cornerstone netted with a $31.3 million recovery of receivables from Cornerstone in the year ago period, $5.9 million in unrealized gains on the Company’s investment in Cyclo equity and the inclusion of Cyclo following closing of the acquisition in March 2025 and the activity of Cornerstone and Day Three, following their consolidation. Research and development expenses were $12.8 million for the twelve months ended July 31, 2025, compared to $4.2 million in the year ago period. The year over year increase relates to the inclusion of spending at Cyclo following the March 2025 acquisition of with Cyclo, and the activity of Cornerstone and Day Three, which were consolidated with Rafael Holdings during fiscal 2024. For the twelve months ended July 31, 2025, general and administrative expenses were $13.8 million compared to $8.9 million in the same period in the prior year. The year over year increase relates to spending at Cyclo following the acquisition, and the activity of Cornerstone and Day Three, following their consolidation. About Rafael Holdings, Inc. Rafael Holdings, Inc. is a biotechnology company that develops pharmaceuticals and holds interests in clinical and early stage companies that develop pharmaceuticals and medical devices. Our lead candidate is Trappsol® Cyclo™, which is being evaluated in clinical trials for the potential treatment of Niemann-Pick Disease Type C1 (“NPC1”), a rare, fatal and progressive genetic disorder. We also hold interests in other clinical-stage and early-stage pharmaceutical development companies and an orthopedic-focused medical device company developing instruments to advance minimally invasive surgeries. Our lead candidate, Trappsol® Cyclo™, is the subject of an ongoing pivotal Phase 3 clinical trial. Forward Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation statements regarding our expectations surrounding the potential, safety, efficacy, and regulatory and clinical progress of our product candidates; plans regarding the further evaluation of clinical data; and the potential of our pipeline, including our internal cancer metabolism research programs. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, those disclosed under the caption “Risk Factors” in our Annual Report on Form 10-K for the year ended July 31, 2024, and our other filings with the SEC. These factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change. Contact:Barbara RyanBarbara.ryan@rafaelholdings.com(203) 274-2825 RAFAEL HOLDINGS, INC.CONSOLIDATED BALANCE SHEETS(in thousands, except share and per share data) July 31, 2025 July 31, 2024 ASSETS CURRENT ASSETS Cash and cash equivalents $52,769 $2,675 Available-for-sale securities — 63,265 Prepaid clinical trial costs 1,045 — Interest receivable — 515 Convertible notes receivable, due from Cyclo — 5,191 Other receivables 1,206 — Accounts receivable, net of allowance for credit losses of $245 at July 31, 2025 and July 31, 2024 627 426 Inventory 281 — Prepaid expenses and other current assets 786 430 Total current assets 56,714 72,502 Property and equipment, net 1,596 2,120 Investments – Hedge Funds — 2,547 Investments – Cyclo — 12,010 Convertible notes receivable classified as available-for-sale 1,858 1,146 Goodwill 19,939 3,050 Intangible assets, net 994 1,847 In-process research and development 31,575 1,575 Non-current prepaid clinical trial costs 1,399 — Other assets 34 35 TOTAL ASSETS $114,109 $96,832 LIABILITIES AND EQUITY CURRENT LIABILITIES Accounts payable $6,893 $2,556 Accrued expenses 3,304 1,798 Convertible notes payable 614 614 Other current liabilities 66 113 Due to related parties 723 733 Installment note payable — 1,700 Total current liabilities 11,600 7,514 Accrued expenses, noncurrent 3,895 2,982 Convertible notes payable, noncurrent 78 73 Other liabilities 27 5 Deferred income tax liability 138 — TOTAL LIABILITIES $15,738 $10,574 COMMITMENTS AND CONTINGENCIES EQUITY Class A common stock, $0.01 par value; 35,000,000 shares authorized, 787,163 shares issued and outstanding as of July 31, 2025 and July 31, 2024 8 8 Class B common stock, $0.01 par value; 200,000,000 shares authorized, 50,789,697 issued and outstanding (excluding treasury shares of 101,487) as of July 31, 2025, and 24,142,535 issued and 23,819,948 outstanding (excluding treasury shares of 101,487) as of July 31, 2024 508 238 Additional paid-in capital 322,161 280,048 Accumulated deficit (232,263) (201,743)Treasury stock, at cost; 101,487 Class B shares as of July 31, 2025 and July 31, 2024 (168) (168)Accumulated other comprehensive income related to unrealized income on available-for-sale securities 358 111 Accumulated other comprehensive income related to foreign currency translation adjustment 3,787 3,691 Total equity attributable to Rafael Holdings, Inc. 94,391 82,185 Noncontrolling interests 3,980 4,073 TOTAL EQUITY 98,371 86,258 TOTAL LIABILITIES AND EQUITY $114,109 $96,832 RAFAEL HOLDINGS, INC.CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS)(in thousands, except share and per share data) Three Months Ended July 31, Year Ended July 31, 2025 2024 2025 2024 Revenues$350 $165 $917 $637 Cost of infusion Technology revenue - 69 106 154 Cost of product revenue 19 - 28 - G&A Expenses 5,497 2,330 13,781 8,854 R&D Expenses 7,547 1,543 12,823 4,170 In-process research and development expense - - - 89,861 Depreciation and amortization 50 68 288 225 Loss on impairment of goodwill - - 3,050 - Operating Loss (12,763) (3,845) (29,159) (102,627)Interest income 467 606 1,996 2,383 Loss on initial investment in Day Three upon acquisition - - - (1,633)Realized gain on available-for-sale securities - 251 178 1,772 Realized loss on investment in equity securities - - - (46)Realized gain on investment - Cyclo - - - 424 Unrealized (loss) gain on investment - Cyclo - (3,162) (5,144) 37 Unrealized (loss) gain on convertible notes receivable, due from Cyclo - 1,191 (719) 1,191 Unrealized gain on investment - Hedge Funds - 181 - 63 Recovery of receivables from Cornerstone - - - 31,305 Interest expense (168) (163) (658) (248)Other income, net 236 - 310 118 Loss before incomes taxes (12,228) (4,941) (33,196) (67,261)Benefit from taxes 174 87 2,553 2,680 Equity in loss of Day Three - - - (422)Consolidated net loss (12,054) (4,854) (30,643) (65,003) Consolidated net loss (12,054) (4,854) (30,643) (65,003)Net loss attributable to noncontrolling interests 40 (386) (123) (30,593)Net loss attributable to Rafael Holdings, Inc.$(12,094) $(4,468) $(30,520) $(34,410) Loss per share attributable to common stockholders Basic and diluted$(0.28) $(0.19) $(1.04) $(1.45) Weighted average number of shares used in calculation of loss per share - basic and diluted 43,011,360 23,916,839 29,422,221 23,745,516

Rafael Holdings Reports Fourth Quarter and Full Year Fiscal 2025 Financial Results

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