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Solid Biosciences to Showcase Proprietary Next-Generation Capsid AAV-SLB101 and Cardiac Gene Therapy Pipeline at the 22nd Global CardioVascular Clinical Trialists (CVCT) Forum

1. Solid Biosciences presents AAV-SLB101 at CVCT Forum in D.C. 2. Data emphasizes AAV-SLB101's cardiac genetic medicine potential. 3. Key presentations led by Dr. Gabriel Brooks and Dr. Nicolas Christoforou. 4. Focus on clinical trial enhancement and regulatory streamlining. 5. Solid's diverse pipeline targets rare cardiac and neuromuscular diseases.

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The presentation of significant new data on AAV-SLB101 can generate investor interest and confidence, similar to past data disclosures from biotech firms leading to price increases.

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The article details groundbreaking presentations that can influence stock performance, especially in the biotech sector.

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Immediate investor sentiment is likely due to upcoming conference presentations that could affect market perception quickly.

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Solid Biosciences to Showcase Innovations in Cardiac Gene Therapy at CVCT Forum

Publication Date: December 08, 2025 | Source: GlobeNewsWire

Overview of Solid Biosciences Presentation

Solid Biosciences Inc. (NASDAQ: SLDB), a leading life sciences company, is set to present its proprietary next-generation capsid AAV-SLB101, alongside its cardiac gene therapy pipeline, at the 22nd Global CardioVascular Clinical Trialists (CVCT) Forum. This key event will take place from December 8-10, 2025, in Washington, D.C.

Dr. Gabriel Brooks, Chief Medical Officer at Solid, will not only exhibit a poster but also lead two presentations and participate in two panel discussions during the forum. Meanwhile, Dr. Nicolas Christoforou, Head of Discovery and Translational Development, will discuss the preclinical developments surrounding a therapy for catecholaminergic polymorphic ventricular tachycardia (CPVT).

Goals of the CVCT Forum

The CVCT Forum serves as an annual, invitation-only workshop designed to foster multi-stakeholder dialogue aimed at enhancing the efficacy of clinical trials, expediting regulatory approval processes, and promoting the application of trial-based evidence.

“We will present data illustrating the potential of our precision genetic approach to cardiac diseases, particularly focusing on the benefits of our proprietary, rationally designed capsid, AAV-SLB101,” said Dr. Brooks. “We look forward to discussing our findings with the community of scientists and trialists as we strive to transform the future of cardiovascular disease treatments.”

Details of Presentations and Discussions

Poster Presentation

Title: AAV-SLB101: A Next-Generation Rationally Designed Capsid Demonstrates Highly Potent Cardiac Tropism and Initial Clinical Safety

Presentations

  • Gene-Based Cardiac Therapy Part 1:

    Title: AAV-SLB101: A Next-Generation Rationally Designed Capsid Demonstrates Highly Potent Cardiac Tropism and Initial Clinical Safety

    Presenter: Dr. Gabriel Brooks

  • Gene-Based Cardiac Therapy Part 2:

    Title: Cardiac Gene Therapy – An Industry Perspective: Drive to Inflection Point

    Presenter: Dr. Gabriel Brooks

  • Preclinical Development Presentation:

    Title: Preclinical Development of a Gene Therapy Strategy for Patients with Catecholaminergic Polymorphic Ventricular Tachycardia

    Presenter: Dr. Nicolas Christoforou (on behalf of Silvia Priori, M.D., Ph.D.)

Panel Discussions

  • Debate Part 1:

    Title: What is Needed to Advance Gene Therapy Innovations into the Clinical Stage?

    Panelist: Dr. Gabriel Brooks

  • Debate Part 2:

    Title: Overcoming Specific Gene Therapy Clinical Trial Challenges

    Panelists: Drs. Gabriel Brooks and Nicolas Christoforou

About Solid Biosciences

Solid Biosciences focuses on advancing precision genetic medicines aimed at rare neuromuscular and cardiac diseases. The company’s portfolio includes candidates such as SGT-003 for Duchenne muscular dystrophy and SGT-501 for CPVT, among others.

Solid is dedicated to developing innovative genetic regulators and delivery technologies, impacting the gene therapy landscape significantly. The company's mission is to enhance the quality of life for patients afflicted by these rare diseases.

Forward-Looking Statements

This article contains forward-looking statements regarding Solid Biosciences' expectations and plans. These statements reflect management's current assumptions and are subject to various risks that could cause actual results to differ materially. Interested parties are encouraged to review the company's SEC filings for more detailed information regarding risks and uncertainties.

Investor Contact:

Nicole Anderson, Director, Investor Relations at Solid Biosciences, investors@solidbio.com

Media Contact:

Glenn Silver, FINN Partners, glenn.silver@finnpartners.com

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