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A near-term data readout and enrollment progress in a BTKi-combination study could serve as a positive catalyst for CRIS if results are favorable; but cash runway concerns could temper upside and raise risk of dilution or funding-driven volatility.
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Curis disclosed that 11 sites opened for the TakeAim CLL trial and six patients have been consented, with five to be dosed by July 2026 and data due in December 2026. The program blends emavusertib with zanubrutinib to dual-block NF-kB via BCR and TLR pathways, potentially yielding deeper responses in CLL. The company also cautioned it lacks sufficient cash to fund operations over the next year, creating financing risk.
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