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ESC Data Reinforce Vutrisiran Benefits Across ATTR-CM With Hypertension Potential

Aug 30, 2026, 8:25 AM EDT1 sourcesAI-analyzed
Why it may matterVerify against the original reporting

Positive ESC data across ATTR-CM and hypertension programs could drive sentiment and near-term upside, especially given the potential first-line use of AMVUTTRA and Roche collaboration.

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What happened, with direct paths to the underlying reporting

Alnylam's ESC 2026 data show vutrisiran reduces all-cause mortality and recurrent cardiovascular events in ATTR-CM, regardless of tafamidis use. Pooled Phase 3 analyses confirm consistent benefits across sexes, while post hoc analyses highlight multisystem burden and intrinsic capacity preservation. Zilebesiran data point to blood pressure control potential, reinforcing AMVUTTRA's broader cardiovascular strategy and the Roche collaboration.

  • HELIOS-B: vutrisiran benefits consistent across baseline tafamidis; 654 patients.
  • Pooled Phase 3: consistent effects across sexes; 1,402 patients across four studies.
  • Multisystem burden: real-world ATTR-CM shows multisystem manifestations pre-diagnosis.
  • Zilebesiran: Phase 2 KARDIA-3 shows SBP reductions; nocturnal dipping improved.
  • AMVUTTRA: potential first-line option for ATTR-CM; EU availability subject to reimbursement.

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