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Substantial Phase 2 efficacy signals (OS, ORR, CR) in 1L HNSCC and an ongoing Phase 3 with topline data due later this year create a near-term upside risk/reward for GMAB if Phase 3 confirms or improves results; potential re-rating on data clarity and HPV-agnostic activity.
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Genmab reported updated Phase 2 results for petosemtamab with pembrolizumab in first-line PD-L1+ r/m HNSCC, delivering a median OS of 28.2 months and an ORR of 63% in 43 efficacy-evaluable patients (CR 19%, mPFS 9.0 months). The Phase 3 program is ongoing, with topline data anticipated later this year, representing a near-term catalyst for GMAB if results validate the Phase 2 signals across HPV+ and HPV- disease.
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