Aptevo disclosed that mipletamig, used with venetoclax and azacitidine, achieved a 93% clinical benefit rate in frontline TP53-mutated AML. In 13 of 14 evaluable patients, 11 reached remission, including nine full CRs. The RAINIER program targets dose optimization by year-end with 2027 regulatory discussions, signaling a potential late-stage catalyst if efficacy persists.
Aptevo Therapeutics Inc. shares fell 11.9% to $4.52 in pre-market trading. The company experienced an 82% increase on Wednesday post-clinical data announcement. Market overall was lower, with Dow futures down 0.2% this morning. Other biotech stocks also showed declines during pre-market trading. Smith & Wesson's disappointing earnings report affected overall market sentiment.
APVO stock surged 137.2% with high trading volume. New data from RAINIER trial shows 85% remission in AML patients. No CRS observed; mipletamig demonstrates strong safety profile. Direct offering of $8 million at $3.25 per share announced. Unique immunotherapy approach positions APVO favorably in AML market.