Editas Medicine (EDIT) shares fell 23.8% on lead therapy development halt. Company faces cash crunch; unable to sustain development costs without a partner. EDIT pivots to in vivo therapies; plans to achieve proof of concept in two years. Cost-cutting measures include a 65% workforce reduction to extend cash runway. In vivo candidates are several years away from potential commercialization.
Editas focuses on in vivo gene editing research and therapy. The shift aims to optimize costs and extend cash runway to 2027. Recent advancements showed ~40% editing of the HBG1/2 promoter in HSCs. Editas to reduce 65% of its workforce, including leadership changes. Preclinical data will be shared in early 2025, signaling future progress.
BofA downgraded Editas citing limited near-term catalysts. Editas is partnering for reni-cel in sickle cell disease. Analyst estimates of success in SCD and beta-thal dropped to 10%. Competitors are advancing their SCD and thalassemia programs aggressively. EDIT's price target was reduced to $1 from $13.
- Editas Medicine reported a loss of 76 cents per share in Q1 2024. - Collaboration revenue decreased to $1.1 million in Q1 from $9.8 million year-over-year. - R&D expenses increased, but G&A expenses decreased in Q1. - Editas had $376.8 million in cash as of March 31, 2024, down from $427.1 million in December 31, 2023. - Editas shares fell 11.4% on May 8 following the Q1 earnings announcement. Price Impact Rating: Bearish Impact Horizon Rating: Short-term Type: Earnings