Lexeo finalized the SUNRISE-FA 2 protocol for LX2006 in Friedreich ataxia cardiomyopathy, with enrollment by June 2026 and first dosing imminent. Topline data are targeted for H2 2027, followed by an FDA accelerated-approval submission in H1 2028. Positive progress may unlock near-term upside, but valuation hinges on ongoing execution and financing.
Interim data for LX2006 shows significant cardiac improvements in Friedreich ataxia patients. 5 of 6 participants achieved normal LVMI, indicating strong treatment efficacy. 27% mean LVMI improvement reflects dose-dependent efficacy across treatment cohorts. All participants noted increased frataxin protein expression in cardiac biopsies. Lexeo plans a registrational study by early 2026, aiming for a 2027 readout.