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Aptevo Therapeutics Provides Program Update for Bispecific APVO711, a PD-L1 X CD40 that Combines a Checkpoint Inhibitor and Immune Activation

1. APVO711 shows promising efficacy in AML trials, highlighting Aptevo's innovation. 2. The dual-action of APVO711 targets PD-1/PD-L1 and enhances T cell priming.

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FAQ

Why Bullish?

APVO711's strong performance in trials suggests potential for future growth, akin to other biotech successes following similar developments, such as Novavax during their vaccine trials.

How important is it?

The article highlights significant advancements for APVO, enhancing investor interest and market viability, especially in the oncology field.

Why Long Term?

If APVO711 successfully navigates further trials and regulatory pathways, it could position APVO favorably in the oncology sector over the next few years.

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As lead candidate mipletamig continues to outperform efficacy and safety benchmarks in AML trials, APVO711 exemplifies emerging innovation from Aptevo's proprietary ADAPTIR® platform In preclinical studies, APVO711 demonstrates dual anti-cancer functionality with broad solid tumor potential and developability SEATTLE, WASHINGTON / ACCESS Newswire / May 8, 2025 / Aptevo Therapeutics Inc. (Nasdaq:APVO), a clinical-stage biotechnology company focused on developing novel immune-oncology therapeutics based on its proprietary ADAPTIR® and ADAPTIR-FLEX® platform technologies, today provided a program update for APVO711, a dual mechanism bispecific utilizing the PD-L1 arm to block the PD-1/PD-L1 pathway and the CD40 arm to enhance T cell priming through activation of the stimulatory receptor CD40 on antigen presenting cells. This update highlights the depth and scientific versatility of Aptevo's existing pipeline and reinforces the Company's ability to advance differentiated candidates for solid tumors with significant unmet need.

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