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Aptevo Therapeutics Reports 2Q25 Financial Results And Provides A Business Update

1. APVO introduces APVO455, expanding its bispecific portfolio for solid tumors. 2. Mipletamig reports an impressive 85% remission rate in AML trials.

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$2.2608/11 08:07 AM EDTEvent Start
$2.1108/12 02:55 PM EDTLatest Updated
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FAQ

Why Bullish?

The 85% remission rate is significantly higher than industry benchmarks, likely enhancing investor confidence. Historical similar advancements in biotech, such as Gilead's CAR-T therapies, have led to substantial stock price spikes.

How important is it?

The article highlights significant advancements and funding which directly influence APVO's market potential. Positive clinical trial results and cash runway extension are crucial for maintaining momentum in the biotech sector.

Why Long Term?

With pipeline expansion and strong clinical results, APVO may strengthen its market position over time. Successful long-term trials could lead to partnerships or acquisitions like those seen with other biotech firms.

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GILDMRNAEXAS
Mipletamig's 85% frontline AML remission rate and favorable safety profile drive APVO's differentiated CD3 portfolio expansion with APVO455, a Nectin-4 x CD3 bispecific for multiple solid tumor types CD3 bispecific portfolio now includes three candidates - mipletamig (AML), APVO442 (prostate cancer), and newly added APVO455 - advancing a targeted, tumor-specific strategy uniquely engineered for safety, tumor specificity and clinical impact Mipletamig, continues to outperform benchmarks, trial enrollment continues $15.9 million raised in 2Q25, extending cash runway into late 4Q25 SEATTLE, WASHINGTON / ACCESS Newswire / August 11, 2025 / Aptevo Therapeutics Inc. (Nasdaq:APVO), a clinical-stage biotechnology Company focused on developing novel immune-oncology therapeutics based on its proprietary ADAPTIR® and ADAPTIR-FLEX® platform technologies, today reported financial results for the quarter ended June 30, 2025, and provided a business update. Second Quarter Highlights Pipeline Expansion - Introduced APVO455, a Nectin-4 x CD3 bispecific for solid tumors, expanding the Company's suite of differentiated CRIS-7-derived CD3 - engaging molecules in development, including lead candidate, mipletamig Mipletamig for acute myeloid leukemia (AML) - Achieved 85% remission* rate (11/13 patients) in frontline AML patients across two trials in combination therapy Increased Liquidity - Completed financings that raised a total of $15.9 million, extending cash runway into late 4Q25 Secured an equity line of credit for up to an additional $25 million in capital *Remission = complete remission (CR) and, complete remission with blood markers that have not yet recovered (CRi).

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