StockNews.AI
BCTX
StockNews.AI
39 days

BriaCell's Bria-IMT™ Demonstrates Survival Advantage over Trodelvy® and Control Group in Metastatic Breast Cancer

1. Bria-IMT shows 13.9 months OS in TNBC, surpassing Trodelvy. 2. Bria-IMT offers 17.3 months OS in HR+, outpacing Trodelvy. 3. No treatment discontinuations reported for Bria-IMT. 4. 54 patients in Phase 2 study, median six prior therapies. 5. Positive OS results may boost ongoing Phase 3 study outlook.

8m saved
Insight
Article

FAQ

Why Bullish?

BriaCell's results outperform an established drug (Trodelvy), signaling strong potential for future approval and market capture similar to prior cases like Juno Therapeutics, which had success with their CAR-T therapy, resulting in significant stock gains post-announcements.

How important is it?

The article highlights tangible survival benefits from BCTX’s drug, which indicates a strong market position and future potential for FDA approval, influencing both investor sentiment and stock valuation.

Why Long Term?

The positive data strengthens BCTX's position leading to potential successful market entry, similar to early-phase results of other biotech firms that led to sustained appreciation over months/years.

Related Companies

TROXGILDJNJ
July 11, 2025 07:30 ET  | Source: BriaCell Therapeutics Corp. Median Overall Survival (OS) of 13.9 months in triple negative breast cancer (TNBC) exceeds Trodelvy (11.8 months) and doubles control (6.9 months)OS of 17.3 months in HR+ metastatic breast cancer surpasses Trodelvy (14.4 months) and control (11.2 months)No treatment related discontinuations reported PHILADELPHIA and VANCOUVER, British Columbia, July 11, 2025 (GLOBE NEWSWIRE) -- BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW, BCTXZ) (TSX: BCT) (“BriaCell” or the “Company”), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, today announced updated Phase 2 survival data for its lead immunotherapy candidate, Bria-IMT, in combination with an immune check point inhibitor (CPI). The data show a meaningful survival advantage in heavily pretreated metastatic breast cancer (MBC) patient subtypes: Triple negative breast cancer (TNBC): median overall survival (OS) of 13.9 months vs. 11.8 months for antibody drug conjugate Trodelvy (sacituzumab govitecan-hziy) and 6.9 months single agent chemotherapy data. BriaCell’s median OS has improved from 11.4 months last reported at ASCO in June 2025.1Hormone receptor positive (HR+): median overall survival (OS) of 17.3 months vs. 14.4 months for Trodelvy and 11.2 months in single agent chemotherapy data. “We are thrilled to see our Bria-IMT regimen outperform established benchmarks like Trodelvy in TNBC and HR+ MBC patients,” stated Dr. William V. Williams, BriaCell’s President and CEO. “BriaCell’s patients had failed a median of six prior therapies, underscoring the potential clinical impact of our novel immunotherapy. We look forward to validating these findings in our ongoing pivotal Phase 3 study with overall survival as its primary endpoint.” Table 1: Analysis of survival data for BriaCell’s Phase 2 study versus Trodelvy in MBC patient subsetsBreast Cancer TypeTreatmentMedian # of prior lines of therapyMedian Overall Survival (months)Survival rate at 6 months (%)Survival rate at 12 months (%)TNBC Bria-IMT plus CPI*  613.97856 TNBCTrodelvy1(sacituzumab govitecan-hziy)3**11.880***49***Single agent chemotherapy3**6.956***22***HR+ Bria-IMT plus CPI* 617.39061 HR+Trodelvy1(sacituzumab govitecan-hziy)414.483***61Single agent chemotherapy411.276***47* Patients treated with the Phase 3 formulation** Prior chemotherapy-containing regimens*** Derived from published Kaplan-Meier curves see1    1.  https://www.gilead.com/-/media/files/pdfs/medicines/oncology/trodelvy/trodelvy_pi.pdf Abbreviations: TNBC: Triple-negative breast cancer (lacks the estrogen receptor, progesterone receptor, and lacks or has low levels of human epidermal growth factor receptor 2 (HER2)) As shown in table 1, median OS number with Bria-IMT is higher than that reported in the treatment arm of the ASCENT study (SG) for TNBC patients, and twice that reported in treatment of physician’s choice arm. HR+: hormone receptor-positive The Phase 2 Bria-IMT study enrolled 54 heavily pre-treated metastatic breast cancer patients (median number of prior treatments = 6) who received the Bria-IMT regimen plus checkpoint inhibitor. Of these 54 patients, 37 received the same formulation currently being used in BriaCell’s ongoing pivotal Phase 3 study in metastatic breast cancer (listed on ClinicalTrials.gov as NCT06072612). No Bria-IMT related discontinuations have been reported to date. About BriaCell Therapeutics Corp. BriaCell is a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care. More information is available at https://briacell.com/. Safe Harbor This press release contains “forward-looking statements” that are subject to substantial risks and uncertainties. All statements, other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements contained in this press release may be identified by the use of words such as “anticipate,” “believe,” “contemplate,” “could,” “estimate,” “expect,” “intend,” “seek,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “target,” “aim,” “should,” “will,” “would,” or the negative of these words or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements, including statements about BriaCell validating positive findings in its ongoing pivotal Phase 3 study with overall survival as its primary endpoint, are based on BriaCell’s current expectations and are subject to inherent uncertainties, risks, and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. These and other risks and uncertainties are described more fully under the heading “Risks and Uncertainties” in the Company’s most recent Management’s Discussion and Analysis, under the heading “Risk Factors” in the Company’s most recent Annual Information Form, and under “Risks and Uncertainties” in the Company’s other filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission, all of which are available under the Company’s profiles on SEDAR+ at www.sedarplus.ca and on EDGAR at www.sec.gov. Forward-looking statements contained in this announcement are made as of this date, and BriaCell Therapeutics Corp. undertakes no duty to update such information except as required under applicable law. Neither the Toronto Stock Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Toronto Stock Exchange) accepts responsibility for the adequacy or accuracy of this release. Contact Information Company Contact:William V. Williams, MDPresident & CEO1-888-485-6340info@briacell.com  Investor Relations Contact:investors@briacell.com 1https://www.gilead.com/-/media/files/pdfs/medicines/oncology/trodelvy/trodelvy_pi.pdf

Related News