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BridgeBio to Present Additional Cardiovascular Outcomes Data from ATTRibute-CM at the HFSA Annual Scientific Meeting 2025

1. BridgeBio presents data on Acoramidis at HFSA Annual Meeting. 2. Significant reduction in all-cause mortality reported with Acoramidis treatment. 3. Poster sessions on Acoramidis effects on NT-proBNP levels and cardiac abnormalities. 4. Acoramidis indicates positive outcomes for variant Transthyretin Amyloidosis. 5. Minor adverse events reported, primarily mild and manageable.

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Why Bullish?

The positive clinical trial outcomes can boost investor confidence, similar to previous biotech successes. Successful presentations at major conferences often lead to increased stock demand.

How important is it?

The upcoming presentations and data could significantly influence market perception and stock price due to their importance in cardiovascular treatments.

Why Short Term?

Market reactions typically follow closely after major presentations, though longer-term effects depend on broader acceptance and commercializing plans.

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September 22, 2025 07:30 ET  | Source: BridgeBio Pharma, Inc. PALO ALTO, Calif., Sept. 22, 2025 (GLOBE NEWSWIRE) -- BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a new type of biopharmaceutical company focused on genetic diseases, announced today that one late breaking clinical trials oral presentation, one oral presentation, and three poster sessions will be shared at the Heart Failure Society of America (HFSA) Annual Scientific Meeting (ASM) 2025, taking place in Minneapolis, MN from September 26 - 29, 2025. Late Breaking Clinical Trials Oral Presentation: Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis from ATTRibute-CMPresenter: Ahmad Masri, M.D., M.S., Oregon Health & Science UniversityDate/time: Sunday, September 28 at 10:15 am CT Oral Presentation: Continuous Acoramidis Treatment Significantly Reduced Risk of All-cause Mortality and Cardiovascular-related Hospitalization at Month 42, in Patients with Wild-type and Variant Transthyretin Amyloidosis Cardiomyopathy Presenter: Lily Stern, M.D., Cedars-Sinai Heart InstituteDate/time: Saturday, September 27 at 1:33 pm CT Poster Sessions: Acoramidis Mitigates the Rise in NT-proBNP Levels Observed with Placebo in Patients with Variant Transthyretin Amyloid Cardiomyopathy: Results from ATTRibute-CM Presenter: Nitasha Sarswat, M.D., UChicago MedicineDate/time: Saturday, September 27 at 7:45 am CT Effect of Acoramidis on Cardiac Conduction Abnormalities in Transthyretin Amyloid Cardiomyopathy Presenter: Brett W. Sperry, M.D., Saint Luke's Health SystemDate/time: Saturday, September 27 at 1:21 pm CT State-Level Differences in Incidence of Transthyretin Amyloid Cardiomyopathy in United States Veterans Persist After Introduction of Disease-Modifying TherapyPresenter: Sandesh Dev, M.D., Arizona State UniversityDate/time: Sunday, September 28 at 12:15 pm CT About Attruby™ (acoramidis) INDICATION Attruby is a transthyretin stabilizer indicated for the treatment of the cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM) in adults to reduce cardiovascular death and cardiovascular-related hospitalization. IMPORTANT SAFETY INFORMATION Adverse Reactions Diarrhea (11.6% vs 7.6%) and upper abdominal pain (5.5% vs 1.4%) were reported in patients treated with Attruby versus placebo, respectively. The majority of these adverse reactions were mild and resolved without drug discontinuation. Discontinuation rates due to adverse events were similar between patients treated with Attruby versus placebo (9.3% and 8.5%, respectively). About BridgeBioBridgeBio Pharma (BridgeBio; NASDAQ:BBIO) is a new type of biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases. BridgeBio’s pipeline of development programs ranges from early science to advanced clinical trials. BridgeBio was founded in 2015 and its team of experienced drug discoverers, developers and innovators are committed to applying advances in genetic medicine to help patients as quickly as possible. For more information visit bridgebio.com and follow us on LinkedIn, Twitter, Facebook, Instagram, and YouTube. BridgeBio Media Contact:Bubba Murarka, Executive Vice President, Corporate Developmentcontact@bridgebio.com   (650)-789-8220 BridgeBio Investor Contact:Chinmay Shukla, Senior Vice President, Strategic Financeir@bridgebio.com

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