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FDA Approval of Eli Lilly's Omvoh for Crohn's Disease Adds a New Option, but Uptake May be Hampered by US Gastroenterologists' Brand Preferences Among the IL-23 Class, According to Spherix Global Insights

1. FDA approved Eli Lilly’s Omvoh for Crohn’s disease. 2. Omvoh faces competition from AbbVie’s Skyrizi and Johnson & Johnson’s Tremfya. 3. Gastroenterologists prefer Tremfya over Omvoh, impacting its market position. 4. IL-23 inhibitors are gaining traction as effective treatment options. 5. Omvoh needs a unique value proposition to differentiate from competitors.

FDA Approval
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FAQ

Why Bearish?

Omvoh's inability to compete effectively could hinder sales growth, affecting LLY's stock.

How important is it?

The article discusses a significant product approval impacting LLY's revenue potential.

Why Short Term?

Initial competition effects on Omvoh will manifest shortly after launch.

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EXTON, PA, Jan. 31, 2025 (GLOBE NEWSWIRE) -- The FDA's approval of Eli Lilly’s Omvoh for Crohn’s disease marks a significant milestone as the therapy becomes the second IL-23 inhibitor available for patients with this challenging condition. Omvoh, already approved for ulcerative colitis, now sets its sights on carving out a niche in the Crohn’s disease market. Yet, stiff competition from AbbVie’s Skyrizi and an expected approval for Johnson & Johnson’s Tremfya raises questions about Omvoh’s ability to stand out in Crohn’s.  Spherix Global Insights recently completed the Q4 2024 wave of its RealTime Dynamix™: Crohn’s Disease (US) service, engaging with 101 U.S.-based gastroenterologists to evaluate the evolving Crohn’s treatment landscape. Findings from this research highlight that while Omvoh enjoys greater familiarity among physicians compared to Tremfya, it faces hurdles in key pre-launch metrics. Nearly half of gastroenterologists view Tremfya as a significant advancement over existing options, compared to just one-third who believe the same for Omvoh. Moreover, over half indicate Tremfya as their preferred IL-23 inhibitor in development for Crohn’s disease, while only 20% selected Omvoh.  Despite these challenges, Omvoh sits within a class that is gaining momentum, with almost half of respondents citing IL-23s as the best overall mechanism of action for Crohn’s treatment. Although TNF inhibitors including adalimumab and infliximab remain the mainstay for first-line biologic treatment in Crohn’s, use of Skyrizi has grown steadily since it was approved, carving out share from the TNFs and Johnson & Johnson’s Stelara. One gastroenterologist from the Spherix study who chose Omvoh as the preferred treatment in development note that the “[The] drug seems to have the right MOA to reduce inflammation and promote remission.”  For Omvoh to grow alongside its fellow IL-23s, the product will need to carve out its own unique value proposition. Omvoh’s initial indication in ulcerative colitis represented Lilly’s first foray into the IBD space, and the brand has grown in share slowly but steadily since launch while facing competition from manufacturers with deep roots in gastroenterology. In ulcerative colitis, Omvoh focused on addressing bowel urgency – a critical patient concern. Gastroenterologists recognize addressing urgency is equally important in Crohn’s disease, with more than two-thirds agreeing that it is an important treatment goal. A gastroenterologist in the Spherix study who indicated preference for Omvoh among treatments in development noted that it can provide “Lasting remission and improved bowel urgency.”  Spherix will closely monitor Omvoh’s impact on the Crohn’s disease market through its RealTime Dynamix™ service. In addition, Spherix will track Omvoh’s performance during the first 18 months post-launch via the Launch Dynamix™ service, slated to begin in February 2025. With the IL-23 class continuing to gain traction, the coming months will reveal whether Omvoh can establish a unique foothold amid fierce competition.  RealTime Dynamix™ is an independent service providing strategic guidance through quarterly or semiannual reports, which include market trending and a fresh infusion of event-driven and variable content with each wave. The reports provide an unbiased view of the competitive landscape within rapidly evolving specialty markets, fueled by robust HCP primary research and our in-house team of experts. Launch Dynamix™ is an independent service providing monthly benchmarking of newly launched products for the first eighteen months of commercial availability, augmented by a quarterly deep dive into promotional activity, barriers to uptake, and patient types gravitating to the launch brand.  About Spherix Global Insights  Spherix is a leading independent market intelligence and advisory firm that delivers commercial value to the global life sciences industry, across the brand lifecycle. The seasoned team of Spherix experts provides an unbiased and holistic view of the landscape within rapidly evolving specialty markets, including dermatology, gastroenterology, rheumatology, nephrology, neurology, ophthalmology, and hematology. Spherix clients stay ahead of the curve with the perspective of the extensive Spherix Physician Community. As a trusted advisor and industry thought leader, Spherix’s unparalleled market insights and advisory services empower clients to make better decisions and unlock opportunities for growth. To learn more about Spherix Global Insights, visit spherixglobalinsights.com or connect through LinkedIn.  For more details on Spherix’s primary market research reports and interactive dashboard offerings, visit or register here: https://clientportal.spherixglobalinsights.com  NOTICE: All company, brand or product names in this press release are trademarks of their respective holders. The findings and opinions expressed within are based on Spherix Global Insight’s analysis and do not imply a relationship with or endorse.

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