1. RYTM shares rose 14.24% following positive Phase 2 trial results. 2. Setmelanotide showed BMI reduction in patients with Prader-Willi syndrome. 3. 17 of 18 patients remain on active setmelanotide therapy. 4. Phase 3 trial plans depend on successful Phase 2 completions. 5. FDA approved a competing hyperphagia treatment for PWS.