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Silexion Therapeutics Announces Completion of Initial Study in Orthotopic Pancreatic Cancer Models Evaluating Systemic Administration of SIL-204

1. Completed first evaluation of SIL-204 in orthotopic pancreatic cancer models. 2. Study evaluated SIL-204’s ability to reduce tumor growth and metastasis. 3. Data analysis underway; initial results expected in March 2025. 4. Milestone offers higher translational value than subcutaneous models.

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Why Bullish?

The milestone study in a more clinically relevant model could boost investor confidence. Similar preclinical breakthroughs in biotech have historically led to positive price moves when later clinical results validate early promise.

How important is it?

The advancement of SIL-204 in a clinically relevant model is a significant preclinical milestone. Although data is pending, it points to a potentially broad therapeutic impact in a high-need area, which may positively affect SLXN’s valuation.

Why Long Term?

Advancement in the therapeutic pipeline influences the company’s strategic direction and future clinical outcomes over several years. Early-stage successes often signal potential long-term market advantages.

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Grand Cayman, Cayman Islands, Feb. 25, 2025 (GLOBE NEWSWIRE) -- Silexion Therapeutics Corp. (NASDAQ: SLXN) ("Silexion" or the "Company"), a clinical-stage biotechnology company pioneering RNA interference (RNAi) therapies for KRAS-driven cancers, today announced the completion of its initial study evaluating SIL-204 in orthotopic pancreatic cancer models. This milestone represents the first systematic evaluation of SIL-204 administered subcutaneously in clinically relevant pancreatic cancer models. The study specifically evaluated two critical aspects of SIL-204's potential therapeutic profile: SIL-204's ability to reduce primary tumor growth when administered systemically in orthotopic pancreatic cancer models, where human tumor cells are implanted directly into the pancreasSIL-204's capacity to reduce metastatic spread from these orthotopic tumors to secondary organs "Completing this initial study in orthotopic models represents a significant milestone in our SIL-204 development program," said Mitchell Shirvan, Ph.D., CSO of Silexion. "These clinically relevant models provide substantially more translational value than standard subcutaneous xenograft models, as they better represent both the complex microenvironment of pancreatic tumors and their characteristic metastatic behavior." The orthotopic models used in this study are designed to more accurately reflect human pancreatic cancer biology by allowing tumors to develop in their native environment. This stands in contrast to subcutaneous xenograft models, where tumors grow beneath the skin rather than in the organ of origin. Importantly, orthotopic pancreatic models demonstrate metastatic spread patterns similar to human disease, enabling evaluation of potential therapies against both primary and metastatic disease. "We are particularly excited about this initial study because it represents the first evaluation of SIL-204 against both primary tumors and their metastases following systemic administration," said Ilan Hadar, Chairman and CEO of Silexion. "Our team is currently analyzing the data, and we expect to begin reporting results in the coming weeks. We are cautiosly optimistic that the findings could provide important insights into SIL-204's potential to address both localized and metastatic pancreatic cancer, which could significantly broaden its therapeutic applications." The Company anticipates sharing initial results from the study in March 2025. These results will inform Silexion's development strategy for SIL-204. About Silexion TherapeuticsSilexion Therapeutics (NASDAQ: SLXN) is a pioneering clinical-stage, oncology-focused biotechnology company developing innovative RNA interference (RNAi) therapies to treat solid tumors driven by KRAS mutations, the most common oncogenic driver in human cancers. The company's first-generation product, LODER™, has shown promising results in a Phase 2 trial for non-resectable pancreatic cancer. Silexion is also advancing its next-generation siRNA candidate, SIL-204, designed to target a broader range of KRAS mutations. The company remains committed to pushing the boundaries of therapeutic innovation in oncology, with a focus on improving outcomes for patients with difficult-to-treat cancers. For more information please visit: https://silexion.com Notice Regarding Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the federal securities laws. All statements other than statements of historical fact contained in this communication, including statements regarding Silexion's business strategy and ongoing studies are forward-looking statements. These forward-looking statements are generally identified by terminology such as "may", "should", "could", "might", "plan", "possible", "project", "strive", "budget", "forecast", "expect", "intend", "will", "estimate", "anticipate", "believe", "predict", "potential" or "continue", or the negatives of these terms or variations of them or similar terminology. Forward-looking statements involve a number of risks, uncertainties, and assumptions, and actual results or events may differ materially from those projected or implied in those statements. Important factors that could cause such differences include, but are not limited to: (i) Silexion's ability to successfully complete preclinical studies and initiate clinical trials; (ii) Silexion's strategy, future operations, financial position, projected costs, prospects, and plans; (iii) the impact of the regulatory environment and compliance complexities; (iv) expectations regarding future partnerships or other relationships with third parties; (v) Silexion's future capital requirements and sources and uses of cash, including its ability to obtain additional capital; and (vi) other risks and uncertainties set forth in the documents filed or to be filed with the SEC by the company. Silexion cautions you against placing undue reliance on forward-looking statements, which reflect current beliefs and are based on information currently available as of the date a forward-looking statement is made. Forward-looking statements set forth herein speak only as of the date they are made. Silexion undertakes no obligation to revise forward-looking statements to reflect future events, changes in circumstances, or changes in beliefs, except as otherwise required by law. Company ContactSilexion Therapeutics CorpMs. Mirit Horenshtein Hadar, CFOmirit@silexion.com Capital Markets & IR ContactARX | Capital Markets AdvisorsNorth American Equities Desksilexion@arxadvisory.com

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