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Enliven Therapeutics Announces New CEO to Drive Next Phase of Development

1. Rick Fair appointed CEO of Enliven, effective December 11, 2025. 2. Transition planned to focus on ELVN-001's pivotal Phase 3 trial for CML. 3. Sam Kintz becomes Head of Pipeline, emphasizing early-stage development. 4. Fair brings 25+ years of oncology and hematology commercialization experience. 5. ELVN-001 shows potential as a best-in-class CML treatment.

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Why Bullish?

The leadership change positively aligns with upcoming pivotal trials for ELVN-001, potentially boosting valuation. Past pharmaceutical transitions have increased investor confidence during pivotal trials.

How important is it?

The appointment of a seasoned CEO at a critical time for ELVN-001 boosts prospects for successful trials and commercialization, crucial for stockholder value.

Why Long Term?

The changes aim to enhance strategic direction for ELVN-001 in 2026 and beyond, indicating a focus on sustaining growth well into the future.

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Enliven Therapeutics Appoints Rick Fair as New CEO to Propel Development of ELVN-001

Enliven Therapeutics, Inc. (Nasdaq: ELVN), a clinical-stage biopharmaceutical company dedicated to developing small molecule therapeutics, has announced the appointment of Rick Fair as Chief Executive Officer, effective December 11, 2025. This strategic leadership transition comes as the company prepares for a pivotal Phase 3 trial of its promising product, ELVN-001, targeting chronic myeloid leukemia (CML).

Transition in Leadership Reflects Expansion Goals

Alongside Fair’s appointment, Enliven’s Co-Founder, Sam Kintz, will take on the newly minted role of Head of Pipeline, also effective on December 11, 2025. This leadership shift exemplifies Enliven's commitment to advance its crucial research initiatives and commercial strategies.

Dr. Richard Heyman, Chairman of the Board, stated, “I am pleased to announce the appointment of Rick Fair. His extensive experience in bringing late-stage oncology and hematology assets to market is invaluable as we look to initiate the crucial Phase 3 clinical trial of ELVN-001 in 2026.”

Rick Fair: A Leader in Oncology and Hematology

Rick Fair brings over 25 years of experience in product development and commercialization to Enliven. He has a strong track record from his tenure at companies such as Bellicum Pharmaceuticals and Roche/Genentech, where he played pivotal roles in developing and launching oncology/hematology therapies that are now integral to their portfolios.

“I am very excited to join Enliven as CEO at this important phase,” said Mr. Fair. “The data generated so far suggest that ELVN-001 could set a new standard as a best-in-class ATP-competitive inhibitor for CML, potentially offering patients improved treatment efficacy and convenience over existing therapies.”

Acknowledging Contributions and Future Focus

Dr. Heyman conveyed his gratitude for Sam Kintz’s contributions as the outgoing CEO, stating, “As a co-founder of Enliven, Sam has been instrumental in the early development of ELVN-001 and its progress into clinical trials.” Kintz will continue driving early-stage research programs, ensuring that Enliven remains focused on its pipeline initiatives.

Kintz expressed his enthusiasm for returned focus on early pipeline efforts, an area of passion for him as a medicinal chemist. “I believe these leadership changes are essential for Enliven's future,” he remarked.

About Enliven Therapeutics

Enliven Therapeutics, based in Boulder, Colorado, is committed to discovering and developing small molecule therapeutics that address unmet needs in precision oncology. The company aims to improve patient survival and overall well-being through innovative drug development strategies.

Forward-Looking Statements

This announcement contains forward-looking statements regarding Enliven's plans and expectations related to the ELVN-001 program and other matters, which involve substantial risks and uncertainties. Actual performance may vary significantly from the projections outlined in this release.

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